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The map label for this gene is uvrD [H]

Identifier: 99081864

GI number: 99081864

Start: 2128764

End: 2131208

Strand: Reverse

Name: uvrD [H]

Synonym: TM1040_2024

Alternate gene names: 99081864

Gene position: 2131208-2128764 (Counterclockwise)

Preceding gene: 99081867

Following gene: 99081862

Centisome position: 66.58

GC content: 61.96

Gene sequence:

>2445_bases
ATGAGCACATTTGACGAAATGGACGCCTTTGAGGGCGCATCATTGTCCGCCCGCGCCATGGCCGCGCGTCCCATGCCCTA
TCTGGATGGTCTCAATCCGGCCCAACGCGACGCGGTGGAGACGCTGGATGGGCCGGTGTTGATGCTGGCGGGCGCGGGCA
CCGGCAAGACAAAGGCGCTGACCACCCGGATCGTGCATCTGTTGAACACGAACAAGGCGCGCACCAACGAGATCCTCGCC
GTGACCTTTACCAACAAGGCCGCGCGCGAAATGAAAGACCGCGTGGGCCGGATGCTCGGTCAGCCTGCCGAGGGCATGCC
GTGGCTCGGCACCTTTCACTCGATCTGCGTGAAGCTCCTGCGCCGACATGCGGAACTGGTGGGGTTGAAGTCCAACTTCA
CCATTCTGGACACCGACGATCAGATCCGCCTGCTGAAACAGCTCATCCAGGCGGCGGGCATCGACGACAAGCGCTGGCCC
GCGCGGATGCTGGCAAACATCATCGACGACTGGAAAAACCGCGCTCTGACGCCTGCCAAGGTGCCTGCGGGGGATGCGGC
GGCCTATAACCATCGCGGCACCGAGTTCTACGACCAGTATCAGACCCGCCTCAAGGAGCTGAACGCGGTTGATTTTGGCG
ATCTGCTGCTGCACTGCGTCGAGATTTTTCAGAACAACCCGGACCTCCTGGCGCAATATCACCGCTGGTTCCGCTACATC
CTCGTGGACGAGTATCAGGATACCAACGTCGCCCAATATCTCTGGTTGCGGCTCTTGGCGTCGGGGCACAAGAACATCTG
CTGCGTGGGCGACGATGACCAGTCGATCTATGGCTGGCGCGGCGCCGAGGTGGGCAACATCCTGCGGTTTGAAAAGGATT
TTTCCGGCGCCAAGGTGATCCGGCTGGAGCAGAATTACCGCTCCACCAAACACATTCTTTCGGCAGCCTCCGGTGTCATC
CGGGGCAACGAAGGGCGGTTGGGCAAGGAGCTCTGGACCGAGGCCGAGGGTGGCGAAAAAGTCCGCCTCATTGGCCATTG
GGACGGTGAGGAAGAGGCCCGCTGGATCGGCGAGGAAATCGAGGCGATGCAGCGTGGCACCCGGGGGATGCGCCAGTATG
GCCTCAATGAAATGGCGATTCTCGTGCGTGCCTCGCACCAGATGCGCGCCTTTGAGGACCGGTTCCTGACCATCGGTCTG
CCGTATCGTGTCATCGGCGGTCCGCGCTTTTACGAGCGGTTGGAAATCCGCGATGCCATGGCCTATTTCCGCGTGGTGAT
CTCGCCCGAAGATGATCTGGCCTTTGAGCGCATCGTCAACACGCCCAAACGCGGCCTTGGCGACAAGGCCCAGCAGACCA
TTCAAACGGTGGCGCGCGCCAATGGCGTCTCTCTCCTTGAGGGCGCGCGGCTTGCGGTCGAGGATGGCCTCATCAAGGGC
AAGGGCGGGGCCGCCTTGCGCCGTCTCGTTGAAAACATCGCCCGTTGGGGCCAGATGACCCGCACCGTGCTGGCCGACCC
GGACGATCCGGACGCGGTGGTCGAGGGCGTGCAGAGCTTTGAGGCGTTTCAGGCCCGTACAGAGGTCTCGCATGTGGAGC
TTGCGGAGATCATCCTGGATGAGAGCGGCTATACCTCCATGTGGCAGGCGGACAAGAACCCCGACAGCCCCGGCCGGCTC
GAGAACCTCAAGGAACTGGTGAAGGCGCTGGAAAACTTCGATAATCTCCAGGGGTTTCTCGAACACGTCAGCCTTGTGAT
GGACAATGACAAGCAAGACGCCGAGCAAAAAGTATCGATCATGACGCTGCATGCCGCCAAAGGGCTGGAGTTCCCGGCGG
TGTTCCTGCCGGGGTGGGAGGATGGGCTCTTTCCCTCGCAGCGCTCGATGGATGAAAGCGGCCTTAAGGGCCTCGAGGAA
GAACGCCGTCTGGCCTATGTGGGCATCACCCGCGCCGAGAAGGTCTGCACGATTTCCTTTGCGGGCAACCGGCGGGTCTT
TGGCCAGTGGCAGTCGCAACTGCCTTCGCGCTTTATTGACGAGCTGCCCGAAGAGCATGTGGATGTGCTGACCCCTCCCG
GCCTCTATGGTGGCGGGTTTGGGGCCGCTGCGCCTTCGGCCTCTGCGGTTGCCGAGCCAGCGGTGCGTTCCACCATCGAG
GAGCGGATGAGCAACGCCGATGGCTATAACTCGCCCGGCTGGAAACGGATGCAGGCCCGCACGGCGGAACGTGGCTACAG
CAAACCGCGCAAGAGCGAGGCGCAGACCATCGACCTGGCGGCGACCTCCAGCTTTACGGTTGGGGAGCGGGTGTTTCACC
AGAAATTCGGCTATGGTGCCGTGGTCGGGATCGAGGGCGACAAGCTCGAGGTGGATTTTGAAAAAGCCGGCCCCAAGAAG
GTGGTGGCGCGCTTTGTTTCCGCCAGCGATGACATCCCGTTCTAA

Upstream 100 bases:

>100_bases
GCACTGCTATGGCGGTGTCACAACATCCGCGCAGCAAGGGTGGGAACGGAGCGTGAACAGACCTCTTCCCGTCCTTTGTG
AAACAGGTTAGGATCGCCGC

Downstream 100 bases:

>100_bases
AGCGCAGGCTTAGAGATTGAGACGGTCGGATCGCTTTGCGATCCGATCCGGGCGGCGGGGCCGCAGCGGCAGGCGCCCCT
GCGGCCCCGCCGCCATACCC

Product: ATP-dependent DNA helicase Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 814; Mature: 813

Protein sequence:

>814_residues
MSTFDEMDAFEGASLSARAMAARPMPYLDGLNPAQRDAVETLDGPVLMLAGAGTGKTKALTTRIVHLLNTNKARTNEILA
VTFTNKAAREMKDRVGRMLGQPAEGMPWLGTFHSICVKLLRRHAELVGLKSNFTILDTDDQIRLLKQLIQAAGIDDKRWP
ARMLANIIDDWKNRALTPAKVPAGDAAAYNHRGTEFYDQYQTRLKELNAVDFGDLLLHCVEIFQNNPDLLAQYHRWFRYI
LVDEYQDTNVAQYLWLRLLASGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFSGAKVIRLEQNYRSTKHILSAASGVI
RGNEGRLGKELWTEAEGGEKVRLIGHWDGEEEARWIGEEIEAMQRGTRGMRQYGLNEMAILVRASHQMRAFEDRFLTIGL
PYRVIGGPRFYERLEIRDAMAYFRVVISPEDDLAFERIVNTPKRGLGDKAQQTIQTVARANGVSLLEGARLAVEDGLIKG
KGGAALRRLVENIARWGQMTRTVLADPDDPDAVVEGVQSFEAFQARTEVSHVELAEIILDESGYTSMWQADKNPDSPGRL
ENLKELVKALENFDNLQGFLEHVSLVMDNDKQDAEQKVSIMTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGLKGLEE
ERRLAYVGITRAEKVCTISFAGNRRVFGQWQSQLPSRFIDELPEEHVDVLTPPGLYGGGFGAAAPSASAVAEPAVRSTIE
ERMSNADGYNSPGWKRMQARTAERGYSKPRKSEAQTIDLAATSSFTVGERVFHQKFGYGAVVGIEGDKLEVDFEKAGPKK
VVARFVSASDDIPF

Sequences:

>Translated_814_residues
MSTFDEMDAFEGASLSARAMAARPMPYLDGLNPAQRDAVETLDGPVLMLAGAGTGKTKALTTRIVHLLNTNKARTNEILA
VTFTNKAAREMKDRVGRMLGQPAEGMPWLGTFHSICVKLLRRHAELVGLKSNFTILDTDDQIRLLKQLIQAAGIDDKRWP
ARMLANIIDDWKNRALTPAKVPAGDAAAYNHRGTEFYDQYQTRLKELNAVDFGDLLLHCVEIFQNNPDLLAQYHRWFRYI
LVDEYQDTNVAQYLWLRLLASGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFSGAKVIRLEQNYRSTKHILSAASGVI
RGNEGRLGKELWTEAEGGEKVRLIGHWDGEEEARWIGEEIEAMQRGTRGMRQYGLNEMAILVRASHQMRAFEDRFLTIGL
PYRVIGGPRFYERLEIRDAMAYFRVVISPEDDLAFERIVNTPKRGLGDKAQQTIQTVARANGVSLLEGARLAVEDGLIKG
KGGAALRRLVENIARWGQMTRTVLADPDDPDAVVEGVQSFEAFQARTEVSHVELAEIILDESGYTSMWQADKNPDSPGRL
ENLKELVKALENFDNLQGFLEHVSLVMDNDKQDAEQKVSIMTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGLKGLEE
ERRLAYVGITRAEKVCTISFAGNRRVFGQWQSQLPSRFIDELPEEHVDVLTPPGLYGGGFGAAAPSASAVAEPAVRSTIE
ERMSNADGYNSPGWKRMQARTAERGYSKPRKSEAQTIDLAATSSFTVGERVFHQKFGYGAVVGIEGDKLEVDFEKAGPKK
VVARFVSASDDIPF
>Mature_813_residues
STFDEMDAFEGASLSARAMAARPMPYLDGLNPAQRDAVETLDGPVLMLAGAGTGKTKALTTRIVHLLNTNKARTNEILAV
TFTNKAAREMKDRVGRMLGQPAEGMPWLGTFHSICVKLLRRHAELVGLKSNFTILDTDDQIRLLKQLIQAAGIDDKRWPA
RMLANIIDDWKNRALTPAKVPAGDAAAYNHRGTEFYDQYQTRLKELNAVDFGDLLLHCVEIFQNNPDLLAQYHRWFRYIL
VDEYQDTNVAQYLWLRLLASGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFSGAKVIRLEQNYRSTKHILSAASGVIR
GNEGRLGKELWTEAEGGEKVRLIGHWDGEEEARWIGEEIEAMQRGTRGMRQYGLNEMAILVRASHQMRAFEDRFLTIGLP
YRVIGGPRFYERLEIRDAMAYFRVVISPEDDLAFERIVNTPKRGLGDKAQQTIQTVARANGVSLLEGARLAVEDGLIKGK
GGAALRRLVENIARWGQMTRTVLADPDDPDAVVEGVQSFEAFQARTEVSHVELAEIILDESGYTSMWQADKNPDSPGRLE
NLKELVKALENFDNLQGFLEHVSLVMDNDKQDAEQKVSIMTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGLKGLEEE
RRLAYVGITRAEKVCTISFAGNRRVFGQWQSQLPSRFIDELPEEHVDVLTPPGLYGGGFGAAAPSASAVAEPAVRSTIEE
RMSNADGYNSPGWKRMQARTAERGYSKPRKSEAQTIDLAATSSFTVGERVFHQKFGYGAVVGIEGDKLEVDFEKAGPKKV
VARFVSASDDIPF

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=792, Percent_Identity=39.7727272727273, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI48994965, Length=656, Percent_Identity=36.890243902439, Blast_Score=391, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322369, Length=737, Percent_Identity=26.4586160108548, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 90749; Mature: 90618

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFDEMDAFEGASLSARAMAARPMPYLDGLNPAQRDAVETLDGPVLMLAGAGTGKTKAL
CCCHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHH
TTRIVHLLNTNKARTNEILAVTFTNKAAREMKDRVGRMLGQPAEGMPWLGTFHSICVKLL
HHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RRHAELVGLKSNFTILDTDDQIRLLKQLIQAAGIDDKRWPARMLANIIDDWKNRALTPAK
HHHHHHEECCCCCEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
VPAGDAAAYNHRGTEFYDQYQTRLKELNAVDFGDLLLHCVEIFQNNPDLLAQYHRWFRYI
CCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVDEYQDTNVAQYLWLRLLASGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFSGAKVI
HHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHEECCCCCCCEEE
RLEQNYRSTKHILSAASGVIRGNEGRLGKELWTEAEGGEKVRLIGHWDGEEEARWIGEEI
EEHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHH
EAMQRGTRGMRQYGLNEMAILVRASHQMRAFEDRFLTIGLPYRVIGGPRFYERLEIRDAM
HHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHCCEEEECCCEEECCCHHHHHHHHHHHHH
AYFRVVISPEDDLAFERIVNTPKRGLGDKAQQTIQTVARANGVSLLEGARLAVEDGLIKG
HHHEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCEEC
KGGAALRRLVENIARWGQMTRTVLADPDDPDAVVEGVQSFEAFQARTEVSHVELAEIILD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ESGYTSMWQADKNPDSPGRLENLKELVKALENFDNLQGFLEHVSLVMDNDKQDAEQKVSI
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHE
MTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGLKGLEEERRLAYVGITRAEKVCTISF
EEEEHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCHHHCCEEEEEEECCCCEEEEEE
AGNRRVFGQWQSQLPSRFIDELPEEHVDVLTPPGLYGGGFGAAAPSASAVAEPAVRSTIE
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ERMSNADGYNSPGWKRMQARTAERGYSKPRKSEAQTIDLAATSSFTVGERVFHQKFGYGA
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCE
VVGIEGDKLEVDFEKAGPKKVVARFVSASDDIPF
EEECCCCEEEEEHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STFDEMDAFEGASLSARAMAARPMPYLDGLNPAQRDAVETLDGPVLMLAGAGTGKTKAL
CCHHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHH
TTRIVHLLNTNKARTNEILAVTFTNKAAREMKDRVGRMLGQPAEGMPWLGTFHSICVKLL
HHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RRHAELVGLKSNFTILDTDDQIRLLKQLIQAAGIDDKRWPARMLANIIDDWKNRALTPAK
HHHHHHEECCCCCEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
VPAGDAAAYNHRGTEFYDQYQTRLKELNAVDFGDLLLHCVEIFQNNPDLLAQYHRWFRYI
CCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVDEYQDTNVAQYLWLRLLASGHKNICCVGDDDQSIYGWRGAEVGNILRFEKDFSGAKVI
HHCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHEECCCCCCCEEE
RLEQNYRSTKHILSAASGVIRGNEGRLGKELWTEAEGGEKVRLIGHWDGEEEARWIGEEI
EEHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHH
EAMQRGTRGMRQYGLNEMAILVRASHQMRAFEDRFLTIGLPYRVIGGPRFYERLEIRDAM
HHHHHHHHHHHHHCCCHHHHEEHHHHHHHHHHCCEEEECCCEEECCCHHHHHHHHHHHHH
AYFRVVISPEDDLAFERIVNTPKRGLGDKAQQTIQTVARANGVSLLEGARLAVEDGLIKG
HHHEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCEEC
KGGAALRRLVENIARWGQMTRTVLADPDDPDAVVEGVQSFEAFQARTEVSHVELAEIILD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ESGYTSMWQADKNPDSPGRLENLKELVKALENFDNLQGFLEHVSLVMDNDKQDAEQKVSI
CCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHE
MTLHAAKGLEFPAVFLPGWEDGLFPSQRSMDESGLKGLEEERRLAYVGITRAEKVCTISF
EEEEHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCHHHCCEEEEEEECCCCEEEEEE
AGNRRVFGQWQSQLPSRFIDELPEEHVDVLTPPGLYGGGFGAAAPSASAVAEPAVRSTIE
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ERMSNADGYNSPGWKRMQARTAERGYSKPRKSEAQTIDLAATSSFTVGERVFHQKFGYGA
HHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCE
VVGIEGDKLEVDFEKAGPKKVVARFVSASDDIPF
EEECCCCEEEEEHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA