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The map label for this gene is mraY

Identifier: 99081860

GI number: 99081860

Start: 2124111

End: 2125193

Strand: Direct

Name: mraY

Synonym: TM1040_2020

Alternate gene names: 99081860

Gene position: 2124111-2125193 (Clockwise)

Preceding gene: 99081859

Following gene: 99081863

Centisome position: 66.36

GC content: 60.3

Gene sequence:

>1083_bases
ATGCTTTATTGGTTGACCGCACTGTCGGACGGGGGAGATTTCTTCAACCTCTTCCGCTATATCACCTTCCGCGCAGGCGG
GGCCTTTCTGACGGCTCTGATCTTTGGCTTTGTATTTGGCAAACCGCTGATCAACGTGCTGCGCAAACGCCAGGGCAAGG
GCCAGCCGATCCGCGACGATGGCCCCGAGGCGCATCTCGCGAAGGTCGGCACCCCCACCATGGGGGGCCTGTTGATCGTC
GGGGCGCTGCTGTTTTCCACCCTCATGTGGGCGCGCTGGGACAATCCGTTTGTCTGGCTAGTGCTGTTTGTGACCATGTC
CTTTGGGCTCATCGGGTTTGCCGATGACTATGCCAAGGTCTCCAAACAGAACACCAGTGGGGTGTCGGGCAAGGTGCGGC
TGCTTTTGGGGTTTGTGATCGCCATCGTGGCCGCGCTCTGGGCGAGCTGGAACCACCCGGCTGAGCTGCAGAACCAGCTG
GCGATGCCGGTCTTTAAGGACGTTCTGCTGAACCTCGGCTATCTGTATGTGCCCTTCTGCATCTGCGTGATCGTGGGGGC
CGCCAATGCGGTGAACCTCACAGATGGGCTCGATGGGCTTGCGATCATGCCGGTGATGATCGCGGCAGGCACGCTTGGGA
TCATCGCCTATGCGGTGGGGCGTGTGGATTTCTCGGAATATCTCGATGTGCATTACGTGCCGGGGACAGGCGAGATCCTG
ATCTTCACCTCGGCGCTCTTTGGCGGGGGTCTTGGCTTCCTGTGGTACAACGCCCCGCCCGCTGCGGTGTTCATGGGCGA
CACCGGCTCGCTGGCGCTTGGTGGTGCCTTGGGGGCCATTGCGATCTCGACCAAACACGAACTGGTGCTGGCCATCGTCG
GCGGGCTCTTTGTGGTCGAAGCGCTATCGGTCATTATTCAGGTGCTCTACTTCAAGCGCACCGGCCGGCGGGTGTTTCTG
ATGGCCCCGATCCATCACCACTACGAGAAAAAAGGCTGGGCAGAGCCGACCATCGTGATCCGCTTCTGGATCATCTCGCT
GATCCTCGCGATGATCGGCCTGGCAACACTGAAGGTGCGCTAA

Upstream 100 bases:

>100_bases
CGGTGGCCCGCGTGGTTGACGCGATCCGCGAAATCGGTCAAGGCAACGCACCTTCGTGACTCGTAATGATAGACCCACTT
AAGACAGGACCCGCACTGGC

Downstream 100 bases:

>100_bases
CCCACGCTAATTCAGCGCTTGCGGCCTGAGCTGCAGCGTCTGTTTCTCTCTGAGCTATGAAAGCCGCGCGGGGGACACCT
TGGCGCGGCTTCGCTTTTAA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MLYWLTALSDGGDFFNLFRYITFRAGGAFLTALIFGFVFGKPLINVLRKRQGKGQPIRDDGPEAHLAKVGTPTMGGLLIV
GALLFSTLMWARWDNPFVWLVLFVTMSFGLIGFADDYAKVSKQNTSGVSGKVRLLLGFVIAIVAALWASWNHPAELQNQL
AMPVFKDVLLNLGYLYVPFCICVIVGAANAVNLTDGLDGLAIMPVMIAAGTLGIIAYAVGRVDFSEYLDVHYVPGTGEIL
IFTSALFGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAISTKHELVLAIVGGLFVVEALSVIIQVLYFKRTGRRVFL
MAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR

Sequences:

>Translated_360_residues
MLYWLTALSDGGDFFNLFRYITFRAGGAFLTALIFGFVFGKPLINVLRKRQGKGQPIRDDGPEAHLAKVGTPTMGGLLIV
GALLFSTLMWARWDNPFVWLVLFVTMSFGLIGFADDYAKVSKQNTSGVSGKVRLLLGFVIAIVAALWASWNHPAELQNQL
AMPVFKDVLLNLGYLYVPFCICVIVGAANAVNLTDGLDGLAIMPVMIAAGTLGIIAYAVGRVDFSEYLDVHYVPGTGEIL
IFTSALFGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAISTKHELVLAIVGGLFVVEALSVIIQVLYFKRTGRRVFL
MAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR
>Mature_360_residues
MLYWLTALSDGGDFFNLFRYITFRAGGAFLTALIFGFVFGKPLINVLRKRQGKGQPIRDDGPEAHLAKVGTPTMGGLLIV
GALLFSTLMWARWDNPFVWLVLFVTMSFGLIGFADDYAKVSKQNTSGVSGKVRLLLGFVIAIVAALWASWNHPAELQNQL
AMPVFKDVLLNLGYLYVPFCICVIVGAANAVNLTDGLDGLAIMPVMIAAGTLGIIAYAVGRVDFSEYLDVHYVPGTGEIL
IFTSALFGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAISTKHELVLAIVGGLFVVEALSVIIQVLYFKRTGRRVFL
MAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=364, Percent_Identity=51.9230769230769, Blast_Score=338, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_SILST (Q1GF14)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614014.1
- STRING:   Q1GF14
- GeneID:   4077477
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2020
- NMPDR:   fig|292414.1.peg.395
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q1GF14
- ProtClustDB:   PRK00108
- BioCyc:   SSP292414:TM1040_2020-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 39018; Mature: 39018

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xff41e20)-; HASH(0x111edc5c)-; HASH(0x111e436c)-; HASH(0x111e1770)-; HASH(0x111e1908)-; HASH(0x111e4384)-; HASH(0x111d5aac)-; HASH(0xf403814)-; HASH(0x111d5a4c)-; HASH(0x111ea948)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYWLTALSDGGDFFNLFRYITFRAGGAFLTALIFGFVFGKPLINVLRKRQGKGQPIRDD
CEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPEAHLAKVGTPTMGGLLIVGALLFSTLMWARWDNPFVWLVLFVTMSFGLIGFADDYAKV
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHCCCHHHHHH
SKQNTSGVSGKVRLLLGFVIAIVAALWASWNHPAELQNQLAMPVFKDVLLNLGYLYVPFC
HCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
ICVIVGAANAVNLTDGLDGLAIMPVMIAAGTLGIIAYAVGRVDFSEYLDVHYVPGTGEIL
HHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCEE
IFTSALFGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAISTKHELVLAIVGGLFVVE
EEEHHHHCCCCEEEEECCCCCEEEECCCCCEECCCHHHHEEECCCHHHHHHHHHHHHHHH
ALSVIIQVLYFKRTGRRVFLMAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR
HHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLYWLTALSDGGDFFNLFRYITFRAGGAFLTALIFGFVFGKPLINVLRKRQGKGQPIRDD
CEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPEAHLAKVGTPTMGGLLIVGALLFSTLMWARWDNPFVWLVLFVTMSFGLIGFADDYAKV
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHCCCHHHHHH
SKQNTSGVSGKVRLLLGFVIAIVAALWASWNHPAELQNQLAMPVFKDVLLNLGYLYVPFC
HCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
ICVIVGAANAVNLTDGLDGLAIMPVMIAAGTLGIIAYAVGRVDFSEYLDVHYVPGTGEIL
HHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEEECCCCCEE
IFTSALFGGGLGFLWYNAPPAAVFMGDTGSLALGGALGAIAISTKHELVLAIVGGLFVVE
EEEHHHHCCCCEEEEECCCCCEEEECCCCCEECCCHHHHEEECCCHHHHHHHHHHHHHHH
ALSVIIQVLYFKRTGRRVFLMAPIHHHYEKKGWAEPTIVIRFWIISLILAMIGLATLKVR
HHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA