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The map label for this gene is 99081846

Identifier: 99081846

GI number: 99081846

Start: 2111425

End: 2112573

Strand: Direct

Name: 99081846

Synonym: TM1040_2006

Alternate gene names: NA

Gene position: 2111425-2112573 (Clockwise)

Preceding gene: 99081844

Following gene: 99081847

Centisome position: 65.96

GC content: 59.44

Gene sequence:

>1149_bases
ATGAATGATCTCAGCTCTCCCCCCACGGTTGCGACCATTGCGGGCCTTGGTGACAAAGGTCTCGATATTACCCTGGCCGA
CGGCGCGACCCATTATTTCAATTACTACTGGCTGCGCGACAACTGCCCCAGCTCCTTTAGCGCCATGACCCGCGAGCGCA
GCTTTGACATCTTTCATCTGGAGACCGCCCCACGCGCAAGAACGGCCGAGATTGACGGGGACGCGCTGGTGATCGACTGG
CAGGACGAAGACCACATCACCCGCATGCCGCTCTCTTGGCTCAATGCCTATGCGGGTGGGCAGCGCCGCCCCGACCCAGC
CGATCTGTCGCGCGTGGCCTGGTTTGGCGATCACTACCCATCGGTGCCGCGGTTCTCGCAGCCCGATCTGGTCTCGGATG
ACGCGACCCGCGCCAAATGGATCGAGGCGATGCTGGTGCATGGTTTCACGATCGTGACCGACATGCCCGACAGCGATGCG
GCGCTCACCCAGACGGCAGAGCTCATGGGCTTTGTGCGGCCCACCTTCTTTGGCACCTATTTTGATGTCAAAACCCACAT
CAACCCCACCAATACCGCCTATACTGCGGGCGCACTAGAGCTGCACACCGACACCCCGGCCGAGGAATTTGCGCCGGGTA
TCCAGTTCCTCCATTGCCGCATCAACACGGTTGACGGTGGCGAGAGCCTCTATGCCGATGGGGTGGCGGTGGCCAATGAC
TTTCGCAAGCGCGACCCAGAGGGCTTCAGGCTTCTCAGCGAAGTGCCGATCCCGTTTTACTGCGAACACGACACTTATGA
TGCGCGCTCGCGCCAATATGTGATCGAGCTGGATCAACACGGCGAAGTCGAGGGGCTCACGATCAGTCAGCATATGGCCG
ATATTTTCGACCTCGATCAGAAACTGCTCGATGACTACTACCCCGCGTTCTGCCGCTTTGGTCGGATGCTGCAGGAAGAG
AAATACATGATGCGCTTTTTGATGAAGGGCGGTGAATGCATGGTCTTTGACAACCATCGCATCGTGCATGGCCGCGCCGC
CTATACCGCCTCCAGTGGTGACCGGTATCTGCGCGGCTGCTACGTGGATCGCTCCGAGATGCGCTCCACCTATCGTGCAT
TGGTCAGCGAAGGACGGTTCAAGGCATGA

Upstream 100 bases:

>100_bases
TCCTTAGATTAAGTTATCTTCACCCGAAACAGGCTGTCGTCAAGCCCTCCCGTGGTGAAATACTGCGGCAAAGACACTCC
TCAGGAAAGGCAATCCAGCC

Downstream 100 bases:

>100_bases
CCCTCACACGCGCCCTCCCCGATGCCGAGGCCCAGTTGCGGACCGATCTCGCAGATGCCTTTCGGATCTGTCACATGCTG
GGCTGGTCCGAAAGTGTCGG

Product: gamma-butyrobetaine,2-oxoglutarate dioxygenase

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNDLSSPPTVATIAGLGDKGLDITLADGATHYFNYYWLRDNCPSSFSAMTRERSFDIFHLETAPRARTAEIDGDALVIDW
QDEDHITRMPLSWLNAYAGGQRRPDPADLSRVAWFGDHYPSVPRFSQPDLVSDDATRAKWIEAMLVHGFTIVTDMPDSDA
ALTQTAELMGFVRPTFFGTYFDVKTHINPTNTAYTAGALELHTDTPAEEFAPGIQFLHCRINTVDGGESLYADGVAVAND
FRKRDPEGFRLLSEVPIPFYCEHDTYDARSRQYVIELDQHGEVEGLTISQHMADIFDLDQKLLDDYYPAFCRFGRMLQEE
KYMMRFLMKGGECMVFDNHRIVHGRAAYTASSGDRYLRGCYVDRSEMRSTYRALVSEGRFKA

Sequences:

>Translated_382_residues
MNDLSSPPTVATIAGLGDKGLDITLADGATHYFNYYWLRDNCPSSFSAMTRERSFDIFHLETAPRARTAEIDGDALVIDW
QDEDHITRMPLSWLNAYAGGQRRPDPADLSRVAWFGDHYPSVPRFSQPDLVSDDATRAKWIEAMLVHGFTIVTDMPDSDA
ALTQTAELMGFVRPTFFGTYFDVKTHINPTNTAYTAGALELHTDTPAEEFAPGIQFLHCRINTVDGGESLYADGVAVAND
FRKRDPEGFRLLSEVPIPFYCEHDTYDARSRQYVIELDQHGEVEGLTISQHMADIFDLDQKLLDDYYPAFCRFGRMLQEE
KYMMRFLMKGGECMVFDNHRIVHGRAAYTASSGDRYLRGCYVDRSEMRSTYRALVSEGRFKA
>Mature_382_residues
MNDLSSPPTVATIAGLGDKGLDITLADGATHYFNYYWLRDNCPSSFSAMTRERSFDIFHLETAPRARTAEIDGDALVIDW
QDEDHITRMPLSWLNAYAGGQRRPDPADLSRVAWFGDHYPSVPRFSQPDLVSDDATRAKWIEAMLVHGFTIVTDMPDSDA
ALTQTAELMGFVRPTFFGTYFDVKTHINPTNTAYTAGALELHTDTPAEEFAPGIQFLHCRINTVDGGESLYADGVAVAND
FRKRDPEGFRLLSEVPIPFYCEHDTYDARSRQYVIELDQHGEVEGLTISQHMADIFDLDQKLLDDYYPAFCRFGRMLQEE
KYMMRFLMKGGECMVFDNHRIVHGRAAYTASSGDRYLRGCYVDRSEMRSTYRALVSEGRFKA

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI4502369, Length=353, Percent_Identity=30.028328611898, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI8922625, Length=354, Percent_Identity=27.4011299435028, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI296317249, Length=231, Percent_Identity=29.8701298701299, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17534641, Length=403, Percent_Identity=25.3101736972705, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71992672, Length=356, Percent_Identity=23.0337078651685, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639015, Length=362, Percent_Identity=31.767955801105, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI19922166, Length=397, Percent_Identity=28.9672544080605, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI221329931, Length=356, Percent_Identity=27.5280898876405, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24648401, Length=355, Percent_Identity=26.4788732394366, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR010376
- InterPro:   IPR003819 [H]

Pfam domain/function: PF06155 DUF971; PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 43314; Mature: 43314

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLSSPPTVATIAGLGDKGLDITLADGATHYFNYYWLRDNCPSSFSAMTRERSFDIFHL
CCCCCCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEEECCCCCHHHHHHHHCCCEEEEE
ETAPRARTAEIDGDALVIDWQDEDHITRMPLSWLNAYAGGQRRPDPADLSRVAWFGDHYP
CCCCCCEEEECCCCEEEEEECCCCCEEECCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
SVPRFSQPDLVSDDATRAKWIEAMLVHGFTIVTDMPDSDAALTQTAELMGFVRPTFFGTY
CCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEE
FDVKTHINPTNTAYTAGALELHTDTPAEEFAPGIQFLHCRINTVDGGESLYADGVAVAND
EEEEECCCCCCCEEECCEEEEECCCCHHHHCCCEEEEEEEEEECCCCCCCEECCCHHHHH
FRKRDPEGFRLLSEVPIPFYCEHDTYDARSRQYVIELDQHGEVEGLTISQHMADIFDLDQ
HHHCCCHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHH
KLLDDYYPAFCRFGRMLQEEKYMMRFLMKGGECMVFDNHRIVHGRAAYTASSGDRYLRGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCEEEECCCCCCEEEEE
YVDRSEMRSTYRALVSEGRFKA
ECCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNDLSSPPTVATIAGLGDKGLDITLADGATHYFNYYWLRDNCPSSFSAMTRERSFDIFHL
CCCCCCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEEECCCCCHHHHHHHHCCCEEEEE
ETAPRARTAEIDGDALVIDWQDEDHITRMPLSWLNAYAGGQRRPDPADLSRVAWFGDHYP
CCCCCCEEEECCCCEEEEEECCCCCEEECCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCC
SVPRFSQPDLVSDDATRAKWIEAMLVHGFTIVTDMPDSDAALTQTAELMGFVRPTFFGTY
CCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEE
FDVKTHINPTNTAYTAGALELHTDTPAEEFAPGIQFLHCRINTVDGGESLYADGVAVAND
EEEEECCCCCCCEEECCEEEEECCCCHHHHCCCEEEEEEEEEECCCCCCCEECCCHHHHH
FRKRDPEGFRLLSEVPIPFYCEHDTYDARSRQYVIELDQHGEVEGLTISQHMADIFDLDQ
HHHCCCHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEHHHHHHHHHHHHH
KLLDDYYPAFCRFGRMLQEEKYMMRFLMKGGECMVFDNHRIVHGRAAYTASSGDRYLRGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEECCEEEECCCCCCEEEEE
YVDRSEMRSTYRALVSEGRFKA
ECCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504802 [H]