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The map label for this gene is aphA [H]

Identifier: 99081837

GI number: 99081837

Start: 2101188

End: 2102966

Strand: Direct

Name: aphA [H]

Synonym: TM1040_1997

Alternate gene names: 99081837

Gene position: 2101188-2102966 (Clockwise)

Preceding gene: 99081834

Following gene: 99081838

Centisome position: 65.64

GC content: 58.8

Gene sequence:

>1779_bases
ATGGCACATACAGCCCCTCACCATAAGAAGATCTCCACCCTGCACATGCTCGTCATTGGCCTGTCTCTCGCCATGACAAT
CGGCGCCTGGCTCTATTCGAAACACCAAGTGGACAAGCAGATCGAGGCCCGTTTCATCGCCTCGCGCGATCGCACCGTCG
ACCTCATCGTGGATCGCATGTCACGCTACGAGGATGCCTTGTGGTCCGGCGTCGCGCACGCCCGTTCCCTGAGCGGTGAG
CTGAACGCGCGCGACTGGCATACGTTTTCCGAAACGCTTCACATCGAAGAGAAATACCCCGGTGTGAACGGTATTGGCTT
CATTCACAATGTAGAGCGCACTGACCTGCCCGCCTACCACGAGGCAAGGAGCAGCGAAGGGCGGCCGATCCAAATCTATC
CGGAGCATGATCTCGAGTACCTGCTGCCAATCACCTACATCGAGCCCGAAGCCGCCAACGCGGCTGCAATCGGTCTGGAT
GTGGCGCATGAAACCAACCGGCGCACGGGTCTGCTTGCAAGTCGCGACAGCGGCAGCGCGCGCATCACCGGGCCGATTGT
GCTTGTGCAGGACAGCGGCAATACACCCGGTTTTCTGTTCTACACCCCGCTCTACGCAGGCCAAATGCCCACCACCGTCG
CCGAGCGCCGGGAGCGGTTCCTTGGCGTTGTCTATGCGCCCTTTGTGGTGCGCAAGCTTGTGGAGGGCTTGCTTTCGAAG
GATCTGCGGGATGTACGCTTCAGCCTCAGCGATGGCGAGGCGGTGATCTATGACGAACACGGCCCCGACGAGCCGCTGTA
TGACGTGGACCCGATGTTCACCGACACGGTCGTGGTCGACATGTACGGGCGAAAGTGGACGGTCAATCTGCGTACAAACC
TGGCCTTTCGCGCACAGAACAGCTCTGCACAGCCCAGCCTGATCCTTGCCGGCGGACTGGTCATCGAAATCCTGGTGATC
TCGCTGCTGGTGATGCTCTCGCGCTCGACCAAGCAGGCGCATAGTCTCGCGCGCGACCTCACCGCAGAACTGCGTGCCAA
AACCAAACACCTCGAGAAGGCCAATGCCGAAATCGAACAATTTGTCTATGTGGCATCGCATGACCTGAAGACCCCCGCGC
GCGGCATCGGGTTCCTTGTGGATGTGATCGAAGAAGAGCTCGAGGACGTGCTCAAATCCGCCCAAAATCGCGGCGAACTG
CAGATGCAGCTCGATATGATCCGCGACCGCGTGGCGCGTATGAATGATCTCACCAAGGGCATCATGGAATTTTCGCGCGT
CGGCCACTATGGCTCCGAGGGAGAGCCGCGCTTGCCTGTAAGCAACCTGATCGAGGACTGCGTGGCTGATTTTGAGGTTG
ATCCCAAGCAAGTCCATCTGGCCTCGGATGTGAGTGAAATCGCCTGCGACAGCCATAACTTCCGGCGGGTTCTGGAGAAC
CTGATCGGCAACGCTTTCAAATACCACCCTCACCCGCGCGCCGCCAAAGTCGAGGTGGCAATCAAGGATCGCGGAGATCG
CCTGACAGTGAGCGTCAAGGACGACGGCAACGGCATTGCGCCGGAGTTTCACGACAAGATCTTTGACGTCTTTCAAACCC
TACGCAAGGGAACCGAACCCGAAAGCACCGGCATCGGTCTGGCGATTGTGAAAAAGGCGATCCAGCGGCACGGGTTTGAT
ATCACAGTAACCTCATCCGAGGGCCATGGCGCAGAATTCTCATTCTGTTGGCCCAAAGACCGCAGCCAGAGCAGCATGGA
CTTGGAGAACGTAGCCTGA

Upstream 100 bases:

>100_bases
TGGTCACCAAAAGTTAAGGAGTGTGTCCGCAAACTATAACAGCGTGTATAATCACAGATCTCGAGAGTTCTGGCGGATCT
GCGGGTAAGAGGTAGCGATC

Downstream 100 bases:

>100_bases
CATGACTCGTCAAATGAATATCCTGTTGGTCGAAGACGACGACCTCGACGCGATGATGATCAAGCGCGCCATGGCCCAGG
TGGCCCCGGACGCCCATCTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 591

Protein sequence:

>592_residues
MAHTAPHHKKISTLHMLVIGLSLAMTIGAWLYSKHQVDKQIEARFIASRDRTVDLIVDRMSRYEDALWSGVAHARSLSGE
LNARDWHTFSETLHIEEKYPGVNGIGFIHNVERTDLPAYHEARSSEGRPIQIYPEHDLEYLLPITYIEPEAANAAAIGLD
VAHETNRRTGLLASRDSGSARITGPIVLVQDSGNTPGFLFYTPLYAGQMPTTVAERRERFLGVVYAPFVVRKLVEGLLSK
DLRDVRFSLSDGEAVIYDEHGPDEPLYDVDPMFTDTVVVDMYGRKWTVNLRTNLAFRAQNSSAQPSLILAGGLVIEILVI
SLLVMLSRSTKQAHSLARDLTAELRAKTKHLEKANAEIEQFVYVASHDLKTPARGIGFLVDVIEEELEDVLKSAQNRGEL
QMQLDMIRDRVARMNDLTKGIMEFSRVGHYGSEGEPRLPVSNLIEDCVADFEVDPKQVHLASDVSEIACDSHNFRRVLEN
LIGNAFKYHPHPRAAKVEVAIKDRGDRLTVSVKDDGNGIAPEFHDKIFDVFQTLRKGTEPESTGIGLAIVKKAIQRHGFD
ITVTSSEGHGAEFSFCWPKDRSQSSMDLENVA

Sequences:

>Translated_592_residues
MAHTAPHHKKISTLHMLVIGLSLAMTIGAWLYSKHQVDKQIEARFIASRDRTVDLIVDRMSRYEDALWSGVAHARSLSGE
LNARDWHTFSETLHIEEKYPGVNGIGFIHNVERTDLPAYHEARSSEGRPIQIYPEHDLEYLLPITYIEPEAANAAAIGLD
VAHETNRRTGLLASRDSGSARITGPIVLVQDSGNTPGFLFYTPLYAGQMPTTVAERRERFLGVVYAPFVVRKLVEGLLSK
DLRDVRFSLSDGEAVIYDEHGPDEPLYDVDPMFTDTVVVDMYGRKWTVNLRTNLAFRAQNSSAQPSLILAGGLVIEILVI
SLLVMLSRSTKQAHSLARDLTAELRAKTKHLEKANAEIEQFVYVASHDLKTPARGIGFLVDVIEEELEDVLKSAQNRGEL
QMQLDMIRDRVARMNDLTKGIMEFSRVGHYGSEGEPRLPVSNLIEDCVADFEVDPKQVHLASDVSEIACDSHNFRRVLEN
LIGNAFKYHPHPRAAKVEVAIKDRGDRLTVSVKDDGNGIAPEFHDKIFDVFQTLRKGTEPESTGIGLAIVKKAIQRHGFD
ITVTSSEGHGAEFSFCWPKDRSQSSMDLENVA
>Mature_591_residues
AHTAPHHKKISTLHMLVIGLSLAMTIGAWLYSKHQVDKQIEARFIASRDRTVDLIVDRMSRYEDALWSGVAHARSLSGEL
NARDWHTFSETLHIEEKYPGVNGIGFIHNVERTDLPAYHEARSSEGRPIQIYPEHDLEYLLPITYIEPEAANAAAIGLDV
AHETNRRTGLLASRDSGSARITGPIVLVQDSGNTPGFLFYTPLYAGQMPTTVAERRERFLGVVYAPFVVRKLVEGLLSKD
LRDVRFSLSDGEAVIYDEHGPDEPLYDVDPMFTDTVVVDMYGRKWTVNLRTNLAFRAQNSSAQPSLILAGGLVIEILVIS
LLVMLSRSTKQAHSLARDLTAELRAKTKHLEKANAEIEQFVYVASHDLKTPARGIGFLVDVIEEELEDVLKSAQNRGELQ
MQLDMIRDRVARMNDLTKGIMEFSRVGHYGSEGEPRLPVSNLIEDCVADFEVDPKQVHLASDVSEIACDSHNFRRVLENL
IGNAFKYHPHPRAAKVEVAIKDRGDRLTVSVKDDGNGIAPEFHDKIFDVFQTLRKGTEPESTGIGLAIVKKAIQRHGFDI
TVTSSEGHGAEFSFCWPKDRSQSSMDLENVA

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=30.1724137931034, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI48994928, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=24.8995983935743, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=277, Percent_Identity=26.7148014440433, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786600, Length=282, Percent_Identity=25.177304964539, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=265, Percent_Identity=23.3962264150943, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=26.027397260274, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=28.4444444444444, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66097; Mature: 65966

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50839 CHASE ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHTAPHHKKISTLHMLVIGLSLAMTIGAWLYSKHQVDKQIEARFIASRDRTVDLIVDRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SRYEDALWSGVAHARSLSGELNARDWHTFSETLHIEEKYPGVNGIGFIHNVERTDLPAYH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEEHHHCCCCCCCEEEECCCCCCCCCHH
EARSSEGRPIQIYPEHDLEYLLPITYIEPEAANAAAIGLDVAHETNRRTGLLASRDSGSA
HHCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEEEEEEEHHCCCCCCCEEEECCCCCE
RITGPIVLVQDSGNTPGFLFYTPLYAGQMPTTVAERRERFLGVVYAPFVVRKLVEGLLSK
EEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DLRDVRFSLSDGEAVIYDEHGPDEPLYDVDPMFTDTVVVDMYGRKWTVNLRTNLAFRAQN
CHHHHEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEEEEECC
SSAQPSLILAGGLVIEILVISLLVMLSRSTKQAHSLARDLTAELRAKTKHLEKANAEIEQ
CCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
FVYVASHDLKTPARGIGFLVDVIEEELEDVLKSAQNRGELQMQLDMIRDRVARMNDLTKG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
IMEFSRVGHYGSEGEPRLPVSNLIEDCVADFEVDPKQVHLASDVSEIACDSHNFRRVLEN
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEHHHHHHHHHCCCHHHHHHHHH
LIGNAFKYHPHPRAAKVEVAIKDRGDRLTVSVKDDGNGIAPEFHDKIFDVFQTLRKGTEP
HHCCCEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
ESTGIGLAIVKKAIQRHGFDITVTSSEGHGAEFSFCWPKDRSQSSMDLENVA
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCHHHCC
>Mature Secondary Structure 
AHTAPHHKKISTLHMLVIGLSLAMTIGAWLYSKHQVDKQIEARFIASRDRTVDLIVDRM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SRYEDALWSGVAHARSLSGELNARDWHTFSETLHIEEKYPGVNGIGFIHNVERTDLPAYH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEEHHHCCCCCCCEEEECCCCCCCCCHH
EARSSEGRPIQIYPEHDLEYLLPITYIEPEAANAAAIGLDVAHETNRRTGLLASRDSGSA
HHCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEEEEEEEHHCCCCCCCEEEECCCCCE
RITGPIVLVQDSGNTPGFLFYTPLYAGQMPTTVAERRERFLGVVYAPFVVRKLVEGLLSK
EEEEEEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DLRDVRFSLSDGEAVIYDEHGPDEPLYDVDPMFTDTVVVDMYGRKWTVNLRTNLAFRAQN
CHHHHEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEEEEEEECC
SSAQPSLILAGGLVIEILVISLLVMLSRSTKQAHSLARDLTAELRAKTKHLEKANAEIEQ
CCCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
FVYVASHDLKTPARGIGFLVDVIEEELEDVLKSAQNRGELQMQLDMIRDRVARMNDLTKG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHH
IMEFSRVGHYGSEGEPRLPVSNLIEDCVADFEVDPKQVHLASDVSEIACDSHNFRRVLEN
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEHHHHHHHHHCCCHHHHHHHHH
LIGNAFKYHPHPRAAKVEVAIKDRGDRLTVSVKDDGNGIAPEFHDKIFDVFQTLRKGTEP
HHCCCEEECCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
ESTGIGLAIVKKAIQRHGFDITVTSSEGHGAEFSFCWPKDRSQSSMDLENVA
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]