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The map label for this gene is hisN [H]

Identifier: 99081748

GI number: 99081748

Start: 2010784

End: 2011578

Strand: Reverse

Name: hisN [H]

Synonym: TM1040_1907

Alternate gene names: 99081748

Gene position: 2011578-2010784 (Counterclockwise)

Preceding gene: 99081749

Following gene: 99081747

Centisome position: 62.84

GC content: 63.14

Gene sequence:

>795_bases
ATGACACATCCTTCGACGCTGTCTGATCTGGACGTTGCCCGCCGCCTTGCCGAGGCTGCCCGTGCAGCAATCCTTCCGCA
TTTTCGCAACAGCGCCACGGCAGCAGACAACAAGCTGGAGGCAGGCTTCGATCCGGTGACGGTTGCAGATCGCGCTGCCG
AAGAAGCAATGCGCGCGGTCCTGCGCAAGCTGCGCCCGGACGACGGCGTGCTGGGCGAAGAGTTTGCGGCCACCACCGGC
ACCAGCGGGCGGACATGGGTGCTCGATCCTATTGATGGCACACGTGGATTTATCAGTGGCACCCCCACATGGGGTGTTCT
GATTGCGCTCTCGGACGCAAAAGGTCCAATGCTGGGGATCATTGATCAGCCCTATATCGGCGAGCGGTTCGAAGGCTGCC
GCGGTCACGCGCAGGTGGTGGGGCCGCATGGCACCCGCCCGCTCCTGACACGCAAGACCGAAGCGCTCTCCGAGGCGATT
TTGTTCACCACATTCCCCGAGGTTGGAACAGAGGCAGAGCGCACGGGCTTTGAACAGGTGGCACAGCATGTGAAACTCAC
GCGCTATGGCATGGATTGTTACGCCTATGCGCTCTTGGCGGCGGGGACCGTGGATCTTGTGATCGAGGCGGGGCTCAATG
CTTATGATATCCAGGCACCGATTGCCGTGATCGAAGCCGCAGGCGGTCTGGTGACCAACTGGCAGGGCGGGGCGGCCCAT
GAGGGTGGGCGCGCCTTGGCTGCGTCCAATCCGACCATCCACGCCGCGGCGCTGGAGCTGTTGCGCGAGGCTTGA

Upstream 100 bases:

>100_bases
CAGGCCGCGCAACCAAGCCCGGTGGGCAGATTTGGCTTGAAAGCGACTGCGTGGCGTGGCACCCGATCCGGGCCTGCCAC
CTCAATCATCGGGGCTTTTT

Downstream 100 bases:

>100_bases
GACCTCGCATTGCCCGTTCCGGGGGCTGGCATGAAGGGCGCAGGGCAAGGACTTGATGGCAATCGCAGAAACAGTTTTTG
CCATTGGCTGACTTGCCCTG

Product: histidinol-phosphate phosphatase, putative, inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTHPSTLSDLDVARRLAEAARAAILPHFRNSATAADNKLEAGFDPVTVADRAAEEAMRAVLRKLRPDDGVLGEEFAATTG
TSGRTWVLDPIDGTRGFISGTPTWGVLIALSDAKGPMLGIIDQPYIGERFEGCRGHAQVVGPHGTRPLLTRKTEALSEAI
LFTTFPEVGTEAERTGFEQVAQHVKLTRYGMDCYAYALLAAGTVDLVIEAGLNAYDIQAPIAVIEAAGGLVTNWQGGAAH
EGGRALAASNPTIHAAALELLREA

Sequences:

>Translated_264_residues
MTHPSTLSDLDVARRLAEAARAAILPHFRNSATAADNKLEAGFDPVTVADRAAEEAMRAVLRKLRPDDGVLGEEFAATTG
TSGRTWVLDPIDGTRGFISGTPTWGVLIALSDAKGPMLGIIDQPYIGERFEGCRGHAQVVGPHGTRPLLTRKTEALSEAI
LFTTFPEVGTEAERTGFEQVAQHVKLTRYGMDCYAYALLAAGTVDLVIEAGLNAYDIQAPIAVIEAAGGLVTNWQGGAAH
EGGRALAASNPTIHAAALELLREA
>Mature_263_residues
THPSTLSDLDVARRLAEAARAAILPHFRNSATAADNKLEAGFDPVTVADRAAEEAMRAVLRKLRPDDGVLGEEFAATTGT
SGRTWVLDPIDGTRGFISGTPTWGVLIALSDAKGPMLGIIDQPYIGERFEGCRGHAQVVGPHGTRPLLTRKTEALSEAIL
FTTFPEVGTEAERTGFEQVAQHVKLTRYGMDCYAYALLAAGTVDLVIEAGLNAYDIQAPIAVIEAAGGLVTNWQGGAAHE
GGRALAASNPTIHAAALELLREA

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1788882, Length=259, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=238, Percent_Identity=24.3697478991597, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193202570, Length=238, Percent_Identity=26.0504201680672, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320493, Length=249, Percent_Identity=25.7028112449799, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357329, Length=267, Percent_Identity=27.7153558052434, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24664922, Length=266, Percent_Identity=25.5639097744361, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664918, Length=238, Percent_Identity=25.2100840336134, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664926, Length=235, Percent_Identity=24.2553191489362, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27897; Mature: 27766

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPSTLSDLDVARRLAEAARAAILPHFRNSATAADNKLEAGFDPVTVADRAAEEAMRAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LRKLRPDDGVLGEEFAATTGTSGRTWVLDPIDGTRGFISGTPTWGVLIALSDAKGPMLGI
HHHCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEEEC
IDQPYIGERFEGCRGHAQVVGPHGTRPLLTRKTEALSEAILFTTFPEVGTEAERTGFEQV
CCCCCCCCHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHCCHHHH
AQHVKLTRYGMDCYAYALLAAGTVDLVIEAGLNAYDIQAPIAVIEAAGGLVTNWQGGAAH
HHHHHHHHHCHHHHHHHHHHCCHHEEHEECCCCEEECHHHHHHHHHCCCEEECCCCCCCC
EGGRALAASNPTIHAAALELLREA
CCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
THPSTLSDLDVARRLAEAARAAILPHFRNSATAADNKLEAGFDPVTVADRAAEEAMRAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LRKLRPDDGVLGEEFAATTGTSGRTWVLDPIDGTRGFISGTPTWGVLIALSDAKGPMLGI
HHHCCCCCCCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCCCEEEC
IDQPYIGERFEGCRGHAQVVGPHGTRPLLTRKTEALSEAILFTTFPEVGTEAERTGFEQV
CCCCCCCCHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEECCCCCCHHHHCCHHHH
AQHVKLTRYGMDCYAYALLAAGTVDLVIEAGLNAYDIQAPIAVIEAAGGLVTNWQGGAAH
HHHHHHHHHCHHHHHHHHHHCCHHEEHEECCCCEEECHHHHHHHHHCCCEEECCCCCCCC
EGGRALAASNPTIHAAALELLREA
CCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]