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The map label for this gene is betA [H]

Identifier: 99081723

GI number: 99081723

Start: 1980763

End: 1982418

Strand: Reverse

Name: betA [H]

Synonym: TM1040_1882

Alternate gene names: 99081723

Gene position: 1982418-1980763 (Counterclockwise)

Preceding gene: 99081724

Following gene: 99081721

Centisome position: 61.93

GC content: 62.86

Gene sequence:

>1656_bases
ATGAACGCGGATTATGTGATTGTTGGGGCGGGCAGCGCAGGCTGCGCCATGGCCTACCGTCTGAGCGAGGCGGGCAAATC
GGTGCTGGTGATCGAGCATGGTGGCACGGATGCGGGCCCCTTCATCCAGATGCCCGGCGCATTGAGCTACCCCATGAACA
TGTCGATGTATGACTGGGGTTACAAATCCCAGCCCGAGCCGCATCTGGGCGGGCGCGAGCTGGTGACGCCGCGCGGCAAG
GTCATTGGCGGATCCTCTTCGATCAACGGCATGGTCTATGTGCGCGGCCACGCGGGCGACTATAACCACTGGGCCGAAAC
GGGCGCGACCGGCTGGTCCTATGCCGACGTGCTGCCCTATTTCAAACGTATGGAAACCTGGGATGATCGCGGCCATGGCG
GCGATCCCGACTGGCGCGGCACCGACGGCCCGCTGCATGTCACCCGTGGCCCCCGCGACAACCCGCTACATGATGCCTTT
GTGAAGTCCGGGCAGCAGGCGGGGTATCCGGTCACCAAGGATTATAACGGCCAGCAGCAAGAGGGCTTTGGCCCGATGGA
GATGACCGTCCACAAGGGCCGCCGCTGGTCTGCCGCCAATGCCTATCTGAAACCTGCGCTCAAGCGCGACAATTGCGATC
TGATCCGCGCGCTGGCCCGCAAGGTGGTGATCGAGGATGGCCGCGCCGTCGGTGTCGAAGTCGAGCGCGGCGGCAAGATC
GAAGTCATCCGCGCCAATATCGAGGTGATCCTCGCGGCGTCTTCGCTCAACTCGCCCAAGCTCCTGATGCTCTCGGGCAT
TGGCCCCGCCGCACATCTGGCCGAACATGGCATCGACGTCATCGCGGACCGGCCCGGCGTTGGCCAGAACCTGCAGGACC
ATCTGGAGTTCTATTTCCAGTTTGCCTCCAAGAAGCCGATCACGCTCTATAAATACTGGAACCTCTTCGGCAAGGCCTTG
GTCGGGGCGCAGTGGCTCTTTACCAAGACCGGGCTCGGGGCCTCGAACCAGTTCGAGAGCGCGGCCTTCATTCGCTCGGA
CAAGGGGATCGACTATCCCGACATCCAGTATCACTTCCTGCCGATCGCCGTGCGCTATGACGGGCAGGCGGCGGCCGAGG
GCCACGGCTTTCAGGCCCATGTCGGCCCGATGCGCTCGCAGTCGCGCGGCGAGGTAACGCTGGCCAGCGCCGATCCCAAC
GCCGCGCCAAAGATCCTGTTCAACTACATGTCTACCGAGCAGGACTGGATCGATTTCCGCAAATGCGTCCGCCTCACGCG
TGAGATCTTTGCACAGGATGCGATGAAGCCTTTTGTGAAACACGAGATCCAGCCGGGCACCGACCTGCAAACGGACGAGG
AGATCGACGGATTCCTGCGCGAACATGTCGAGAGCGCCTATCACCCCTGCGGCACCTGCAAGATGGGTGCGGTGGATGAT
CCGATGGCGGTGGTTGACCCCGAATGCCGGGTGATTGGCGTCGAGGGGCTGCGGGTGGCGGATAGTTCGATCTTCCCGCG
CATCACCAACGGCAACCTCAACGGGCCCTCGATCATGACCGGCGAGAAAGCCTCCGATCACATTCTGGGGCGCCGTCTGC
CTTCGTCGAATGCCGAGCCGTGGTTCAACCCGAACTGGCAGACCTCGCAGCGTTGA

Upstream 100 bases:

>100_bases
CGTCCCCCAAAAGGACGCGGGCGACCAGAGAGGTTATGTCCTGCGGCGCCGTGAGGCGGGGCAGGGCAGGGTCTCAGCCG
GTGATAGGAGAAGAGACGCG

Downstream 100 bases:

>100_bases
ACCCTGCACTGTTAGTCACGCCTAGCCGCCCCCTGCATCCGCAGAGGGGCGGTTTTTTATAGACATGCCTGAAAGTCATT
GTGGTCGGAAAGCGGTATTT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNADYVIVGAGSAGCAMAYRLSEAGKSVLVIEHGGTDAGPFIQMPGALSYPMNMSMYDWGYKSQPEPHLGGRELVTPRGK
VIGGSSSINGMVYVRGHAGDYNHWAETGATGWSYADVLPYFKRMETWDDRGHGGDPDWRGTDGPLHVTRGPRDNPLHDAF
VKSGQQAGYPVTKDYNGQQQEGFGPMEMTVHKGRRWSAANAYLKPALKRDNCDLIRALARKVVIEDGRAVGVEVERGGKI
EVIRANIEVILAASSLNSPKLLMLSGIGPAAHLAEHGIDVIADRPGVGQNLQDHLEFYFQFASKKPITLYKYWNLFGKAL
VGAQWLFTKTGLGASNQFESAAFIRSDKGIDYPDIQYHFLPIAVRYDGQAAAEGHGFQAHVGPMRSQSRGEVTLASADPN
AAPKILFNYMSTEQDWIDFRKCVRLTREIFAQDAMKPFVKHEIQPGTDLQTDEEIDGFLREHVESAYHPCGTCKMGAVDD
PMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMTGEKASDHILGRRLPSSNAEPWFNPNWQTSQR

Sequences:

>Translated_551_residues
MNADYVIVGAGSAGCAMAYRLSEAGKSVLVIEHGGTDAGPFIQMPGALSYPMNMSMYDWGYKSQPEPHLGGRELVTPRGK
VIGGSSSINGMVYVRGHAGDYNHWAETGATGWSYADVLPYFKRMETWDDRGHGGDPDWRGTDGPLHVTRGPRDNPLHDAF
VKSGQQAGYPVTKDYNGQQQEGFGPMEMTVHKGRRWSAANAYLKPALKRDNCDLIRALARKVVIEDGRAVGVEVERGGKI
EVIRANIEVILAASSLNSPKLLMLSGIGPAAHLAEHGIDVIADRPGVGQNLQDHLEFYFQFASKKPITLYKYWNLFGKAL
VGAQWLFTKTGLGASNQFESAAFIRSDKGIDYPDIQYHFLPIAVRYDGQAAAEGHGFQAHVGPMRSQSRGEVTLASADPN
AAPKILFNYMSTEQDWIDFRKCVRLTREIFAQDAMKPFVKHEIQPGTDLQTDEEIDGFLREHVESAYHPCGTCKMGAVDD
PMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMTGEKASDHILGRRLPSSNAEPWFNPNWQTSQR
>Mature_551_residues
MNADYVIVGAGSAGCAMAYRLSEAGKSVLVIEHGGTDAGPFIQMPGALSYPMNMSMYDWGYKSQPEPHLGGRELVTPRGK
VIGGSSSINGMVYVRGHAGDYNHWAETGATGWSYADVLPYFKRMETWDDRGHGGDPDWRGTDGPLHVTRGPRDNPLHDAF
VKSGQQAGYPVTKDYNGQQQEGFGPMEMTVHKGRRWSAANAYLKPALKRDNCDLIRALARKVVIEDGRAVGVEVERGGKI
EVIRANIEVILAASSLNSPKLLMLSGIGPAAHLAEHGIDVIADRPGVGQNLQDHLEFYFQFASKKPITLYKYWNLFGKAL
VGAQWLFTKTGLGASNQFESAAFIRSDKGIDYPDIQYHFLPIAVRYDGQAAAEGHGFQAHVGPMRSQSRGEVTLASADPN
AAPKILFNYMSTEQDWIDFRKCVRLTREIFAQDAMKPFVKHEIQPGTDLQTDEEIDGFLREHVESAYHPCGTCKMGAVDD
PMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMTGEKASDHILGRRLPSSNAEPWFNPNWQTSQR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=557, Percent_Identity=50.8078994614004, Blast_Score=530, Evalue=1e-150,
Organism=Escherichia coli, GI1786503, Length=548, Percent_Identity=50.1824817518248, Blast_Score=516, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17532301, Length=558, Percent_Identity=46.415770609319, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI45551458, Length=563, Percent_Identity=37.6554174067496, Blast_Score=328, Evalue=7e-90,
Organism=Drosophila melanogaster, GI45549471, Length=563, Percent_Identity=37.6554174067496, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24642042, Length=563, Percent_Identity=36.5896980461812, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24642048, Length=564, Percent_Identity=35.9929078014184, Blast_Score=308, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24642059, Length=564, Percent_Identity=34.5744680851064, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24642055, Length=570, Percent_Identity=34.0350877192982, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI17137792, Length=552, Percent_Identity=34.2391304347826, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24650267, Length=571, Percent_Identity=35.0262697022767, Blast_Score=272, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24642039, Length=563, Percent_Identity=34.6358792184725, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI18859995, Length=562, Percent_Identity=32.5622775800712, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24642037, Length=573, Percent_Identity=33.3333333333333, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24642035, Length=570, Percent_Identity=32.280701754386, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24642051, Length=569, Percent_Identity=30.2284710017575, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=30.3135888501742, Blast_Score=219, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24642057, Length=589, Percent_Identity=26.6553480475382, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645930, Length=587, Percent_Identity=26.2350936967632, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60528; Mature: 60528

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNADYVIVGAGSAGCAMAYRLSEAGKSVLVIEHGGTDAGPFIQMPGALSYPMNMSMYDWG
CCCCEEEEECCCCCHHHHEEHHHCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCEECCC
YKSQPEPHLGGRELVTPRGKVIGGSSSINGMVYVRGHAGDYNHWAETGATGWSYADVLPY
CCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCCCHHHHCCCCCCCHHHHHHH
FKRMETWDDRGHGGDPDWRGTDGPLHVTRGPRDNPLHDAFVKSGQQAGYPVTKDYNGQQQ
HHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHH
EGFGPMEMTVHKGRRWSAANAYLKPALKRDNCDLIRALARKVVIEDGRAVGVEVERGGKI
CCCCCEEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHEECCCCEEEEEECCCCEE
EVIRANIEVILAASSLNSPKLLMLSGIGPAAHLAEHGIDVIADRPGVGQNLQDHLEFYFQ
EEEEECEEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
FASKKPITLYKYWNLFGKALVGAQWLFTKTGLGASNQFESAAFIRSDKGIDYPDIQYHFL
HHCCCCEEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEE
PIAVRYDGQAAAEGHGFQAHVGPMRSQSRGEVTLASADPNAAPKILFNYMSTEQDWIDFR
EEEEEECCCCCCCCCCCEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHH
KCVRLTREIFAQDAMKPFVKHEIQPGTDLQTDEEIDGFLREHVESAYHPCGTCKMGAVDD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMTGEKASDHILGRRLPSSNAEP
CCEEECCCEEEEECCCEEEECCCCCCEECCCCCCCCCEECCCCCCHHHHHCCCCCCCCCC
WFNPNWQTSQR
CCCCCCCCCCC
>Mature Secondary Structure
MNADYVIVGAGSAGCAMAYRLSEAGKSVLVIEHGGTDAGPFIQMPGALSYPMNMSMYDWG
CCCCEEEEECCCCCHHHHEEHHHCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCEECCC
YKSQPEPHLGGRELVTPRGKVIGGSSSINGMVYVRGHAGDYNHWAETGATGWSYADVLPY
CCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCCCHHHHCCCCCCCHHHHHHH
FKRMETWDDRGHGGDPDWRGTDGPLHVTRGPRDNPLHDAFVKSGQQAGYPVTKDYNGQQQ
HHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHH
EGFGPMEMTVHKGRRWSAANAYLKPALKRDNCDLIRALARKVVIEDGRAVGVEVERGGKI
CCCCCEEEEEECCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHEECCCCEEEEEECCCCEE
EVIRANIEVILAASSLNSPKLLMLSGIGPAAHLAEHGIDVIADRPGVGQNLQDHLEFYFQ
EEEEECEEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
FASKKPITLYKYWNLFGKALVGAQWLFTKTGLGASNQFESAAFIRSDKGIDYPDIQYHFL
HHCCCCEEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEE
PIAVRYDGQAAAEGHGFQAHVGPMRSQSRGEVTLASADPNAAPKILFNYMSTEQDWIDFR
EEEEEECCCCCCCCCCCEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHH
KCVRLTREIFAQDAMKPFVKHEIQPGTDLQTDEEIDGFLREHVESAYHPCGTCKMGAVDD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PMAVVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMTGEKASDHILGRRLPSSNAEP
CCEEECCCEEEEECCCEEEECCCCCCEECCCCCCCCCEECCCCCCHHHHHCCCCCCCCCC
WFNPNWQTSQR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA