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The map label for this gene is pccB [H]

Identifier: 99081718

GI number: 99081718

Start: 1974839

End: 1976371

Strand: Reverse

Name: pccB [H]

Synonym: TM1040_1877

Alternate gene names: 99081718

Gene position: 1976371-1974839 (Counterclockwise)

Preceding gene: 99081721

Following gene: 99081717

Centisome position: 61.74

GC content: 60.14

Gene sequence:

>1533_bases
ATGAAGGATATTCTTGCCGAGCTCGAGGAACGCCGCGAAAACGCGCGCCTCGGAGGGGGACAGAAACGTATTGATGCGCA
GCACGCACGCGGCAAACTCACCGCCCGCGAGCGGATCGAACTGCTGCTGGACGAAGGCAGCTTTGAAGAGTTCGACATGT
TCATCAGCCATCGCTGCACGGATTTTGGCATGGAGAACAACAAGCCCGCAGGCGACGGTGTGATCACCGGCTGGGGCACC
ATCAATGGCCGTCAGGTCTATGTGTTCTCGCAGGATTTCACCGTGCTGGGCGGCTCGGTGTCCGCAACCCACGCGCAAAA
GATCTGTAAAATTCAGGACATGGCGATCCAGAACGGCGCGCCGATCATCGGGCTCAACGACTCTGGCGGCGCCCGTATTC
AAGAAGGCGTCGACGCGCTGGCGGGCTATGCCGAGATTTTCCAGCGCAATATCATGGCCTCCGGCGTGATCCCGCAGATC
TCCGTCATCATGGGGCCCTGCGCCGGTGGTGCGGTCTACAGCCCCGCGATGACCGACTTTATCTTTATGGTGAAGGACAC
CTCCTACATGTTCGTGACCGGCCCGGATGTTGTAAAAACCGTGACCAACGAACAGGTTACCGCCGAGGAGCTGGGCGGGG
CCTCCACCCATACCAAGAAATCCTCCGTCGCCGATGGTGCCTTTGAAAACGACGTCGAGGCGCTGGCCGAAGTGCGCCGT
CTGGTGGACTTCCTGCCCGCCAACAATCGTGAAAAGCCGCCCGTGCGCCCGTTCTTTGACGACCCCGCGCGGATTGAGGA
CAGCCTCGATACGCTGATCCCGGAAAACGCCAACACGCCGTATGATATGAAGGAACTCATCACCAAAGTGGCGGATGAGG
GCGATTTCTACGAGATCCAGGAAGACTTCGCCAAGAACATCATCACCGGGTTTGTGCGCCTTGAGGGGCAGACCGTGGGC
GTGGTGGCCAATCAGCCGATGGTGCTCGCAGGCTGTCTTGATATTGACAGCTCTCGCAAGGCGGCACGCTTTGTGCGCTT
CTGCGACGCCTTTGAAATTCCGATCCTGACCTTTGTGGATGTGCCGGGCTTCCTGCCGGGGACCGCACAGGAATACGGCG
GCGTCATCAAGCACGGCGCCAAGCTCCTGTTTGCCTATGGTGAGGCGACGGTGCCAAAGGTCACGGTCATCACTCGCAAG
GCCTATGGCGGTGCCTATGACGTGATGGCCTCCAAACACCTGCGCGGTGATTTCAACTATGCCTGGCCCACTGCCGAGAT
CGCGGTGATGGGCGCCAAGGGCGCAACCGAGATCATCCACCGCGCCGATCTCAATGATCCCGAGAAGATCGCCGCCCATA
CGGCCGACTACGAGGACCGCTTTGCCAATCCCTTTGTGGCGGCCGAGCGCGGGTTCATTGATGAGGTGATCCAGCCCAAA
TCCACCCGCCGCCGCGTGGCGCGCGCCTTTGCCAGCCTGCGTGGCAAAAAGCTCGCGAACCCGTGGAAAAAGCACGACAA
TATTCCGCTCTGA

Upstream 100 bases:

>100_bases
TGCCTTGGGTGCCAGCCTGCGTCAGGCTAGGGTCGCACACAAAGAACCCGGTTCAACCCGTTTGAAACCGTGGGCCCAAA
CTGATCAGGGGGCATTTGCC

Downstream 100 bases:

>100_bases
GCCATTTTGCGCTAGGCAAAAGCTCTATTCAACCAAGGAGCGATTTATGCGTTATCTTTTCGCGTGTCTTTTGATAGCGG
CGGCCTTGCCTGCCGCTGCC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKDILAELEERRENARLGGGQKRIDAQHARGKLTARERIELLLDEGSFEEFDMFISHRCTDFGMENNKPAGDGVITGWGT
INGRQVYVFSQDFTVLGGSVSATHAQKICKIQDMAIQNGAPIIGLNDSGGARIQEGVDALAGYAEIFQRNIMASGVIPQI
SVIMGPCAGGAVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNEQVTAEELGGASTHTKKSSVADGAFENDVEALAEVRR
LVDFLPANNREKPPVRPFFDDPARIEDSLDTLIPENANTPYDMKELITKVADEGDFYEIQEDFAKNIITGFVRLEGQTVG
VVANQPMVLAGCLDIDSSRKAARFVRFCDAFEIPILTFVDVPGFLPGTAQEYGGVIKHGAKLLFAYGEATVPKVTVITRK
AYGGAYDVMASKHLRGDFNYAWPTAEIAVMGAKGATEIIHRADLNDPEKIAAHTADYEDRFANPFVAAERGFIDEVIQPK
STRRRVARAFASLRGKKLANPWKKHDNIPL

Sequences:

>Translated_510_residues
MKDILAELEERRENARLGGGQKRIDAQHARGKLTARERIELLLDEGSFEEFDMFISHRCTDFGMENNKPAGDGVITGWGT
INGRQVYVFSQDFTVLGGSVSATHAQKICKIQDMAIQNGAPIIGLNDSGGARIQEGVDALAGYAEIFQRNIMASGVIPQI
SVIMGPCAGGAVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNEQVTAEELGGASTHTKKSSVADGAFENDVEALAEVRR
LVDFLPANNREKPPVRPFFDDPARIEDSLDTLIPENANTPYDMKELITKVADEGDFYEIQEDFAKNIITGFVRLEGQTVG
VVANQPMVLAGCLDIDSSRKAARFVRFCDAFEIPILTFVDVPGFLPGTAQEYGGVIKHGAKLLFAYGEATVPKVTVITRK
AYGGAYDVMASKHLRGDFNYAWPTAEIAVMGAKGATEIIHRADLNDPEKIAAHTADYEDRFANPFVAAERGFIDEVIQPK
STRRRVARAFASLRGKKLANPWKKHDNIPL
>Mature_510_residues
MKDILAELEERRENARLGGGQKRIDAQHARGKLTARERIELLLDEGSFEEFDMFISHRCTDFGMENNKPAGDGVITGWGT
INGRQVYVFSQDFTVLGGSVSATHAQKICKIQDMAIQNGAPIIGLNDSGGARIQEGVDALAGYAEIFQRNIMASGVIPQI
SVIMGPCAGGAVYSPAMTDFIFMVKDTSYMFVTGPDVVKTVTNEQVTAEELGGASTHTKKSSVADGAFENDVEALAEVRR
LVDFLPANNREKPPVRPFFDDPARIEDSLDTLIPENANTPYDMKELITKVADEGDFYEIQEDFAKNIITGFVRLEGQTVG
VVANQPMVLAGCLDIDSSRKAARFVRFCDAFEIPILTFVDVPGFLPGTAQEYGGVIKHGAKLLFAYGEATVPKVTVITRK
AYGGAYDVMASKHLRGDFNYAWPTAEIAVMGAKGATEIIHRADLNDPEKIAAHTADYEDRFANPFVAAERGFIDEVIQPK
STRRRVARAFASLRGKKLANPWKKHDNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=506, Percent_Identity=66.99604743083, Blast_Score=703, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=525, Percent_Identity=64.5714285714286, Blast_Score=691, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=523, Percent_Identity=33.0783938814532, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI310133460, Length=129, Percent_Identity=37.984496124031, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25147362, Length=504, Percent_Identity=65.0793650793651, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=504, Percent_Identity=65.0793650793651, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=509, Percent_Identity=33.3988212180747, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI71997163, Length=317, Percent_Identity=26.4984227129338, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24586065, Length=519, Percent_Identity=32.3699421965318, Blast_Score=251, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55810; Mature: 55810

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDILAELEERRENARLGGGQKRIDAQHARGKLTARERIELLLDEGSFEEFDMFISHRCT
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
DFGMENNKPAGDGVITGWGTINGRQVYVFSQDFTVLGGSVSATHAQKICKIQDMAIQNGA
HCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHCCCC
PIIGLNDSGGARIQEGVDALAGYAEIFQRNIMASGVIPQISVIMGPCAGGAVYSPAMTDF
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHEECCCCCCCCCCCHHHHE
IFMVKDTSYMFVTGPDVVKTVTNEQVTAEELGGASTHTKKSSVADGAFENDVEALAEVRR
EEEEECCCEEEEECCHHHHHHCCCCEEHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
LVDFLPANNREKPPVRPFFDDPARIEDSLDTLIPENANTPYDMKELITKVADEGDFYEIQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHH
EDFAKNIITGFVRLEGQTVGVVANQPMVLAGCLDIDSSRKAARFVRFCDAFEIPILTFVD
HHHHHHHHHHHEEECCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEC
VPGFLPGTAQEYGGVIKHGAKLLFAYGEATVPKVTVITRKAYGGAYDVMASKHLRGDFNY
CCCCCCCCHHHHCHHHHCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAEIAVMGAKGATEIIHRADLNDPEKIAAHTADYEDRFANPFVAAERGFIDEVIQPK
CCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCHHHHCCHHHHHHCCC
STRRRVARAFASLRGKKLANPWKKHDNIPL
HHHHHHHHHHHHHCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MKDILAELEERRENARLGGGQKRIDAQHARGKLTARERIELLLDEGSFEEFDMFISHRCT
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
DFGMENNKPAGDGVITGWGTINGRQVYVFSQDFTVLGGSVSATHAQKICKIQDMAIQNGA
HCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHCCCC
PIIGLNDSGGARIQEGVDALAGYAEIFQRNIMASGVIPQISVIMGPCAGGAVYSPAMTDF
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHEECCCCCCCCCCCHHHHE
IFMVKDTSYMFVTGPDVVKTVTNEQVTAEELGGASTHTKKSSVADGAFENDVEALAEVRR
EEEEECCCEEEEECCHHHHHHCCCCEEHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
LVDFLPANNREKPPVRPFFDDPARIEDSLDTLIPENANTPYDMKELITKVADEGDFYEIQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHH
EDFAKNIITGFVRLEGQTVGVVANQPMVLAGCLDIDSSRKAARFVRFCDAFEIPILTFVD
HHHHHHHHHHHEEECCEEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEC
VPGFLPGTAQEYGGVIKHGAKLLFAYGEATVPKVTVITRKAYGGAYDVMASKHLRGDFNY
CCCCCCCCHHHHCHHHHCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
AWPTAEIAVMGAKGATEIIHRADLNDPEKIAAHTADYEDRFANPFVAAERGFIDEVIQPK
CCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCHHHHCCHHHHHHCCC
STRRRVARAFASLRGKKLANPWKKHDNIPL
HHHHHHHHHHHHHCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]