Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 99081695

GI number: 99081695

Start: 1954506

End: 1956245

Strand: Direct

Name: luxQ [H]

Synonym: TM1040_1854

Alternate gene names: 99081695

Gene position: 1954506-1956245 (Clockwise)

Preceding gene: 99081685

Following gene: 99081696

Centisome position: 61.06

GC content: 62.24

Gene sequence:

>1740_bases
ATGACCCGAGCCGCCAAATTGACACCTGATCCCTATGATGTGCAGCTGCGCGAACTTGGCCTCGTTCAACGACAACCCGA
CTCCGACATCGACAATCTGACCCGGCTCGCTGCCCAAGTGCTGGATGCGCCAACGGCGCTGGTCTCTGTGGTGCAGCGCA
GCCTTGATCGTCAATTCTTCAAAAGCTGCGTGGGCCTGCCCGAGCTGTCGAGCGTGCTGCGTCAGACACCGCTCTCTCAT
TCGTTTTGCCAATTTGTGCAGGACGCCAACCAGCCTCTGATCGTGCCCGATAGCCGCAATGACGCCCAGCTGCGTGACAA
TGCGGCGGTGATCGACCTCAAGATGGTTGCCTATCTGGGGGTGCCGATTCATTTGCCGGATGGAACGCCCATTGGTGCGC
TCTGCGTCATTGATCGCGTGCCGCGTCAGTGGAGCTCGGACAATCTCAAGACCCTGCAACACCTTGCGGTGGCCGTCGAC
AATGTCATCGCCCTGAAACATGCGCGCGAACTCGCCGCCGAGGCAGAGCGCACTGCCAAACGCGAAGCCGAGGCGCGTAA
GACCTACCTTGCCCACATGAGCCACGAGATCCGCACGCCGCTCAATGGCATCATCGGCTCGGTCGATCTGTTGCTGCGCG
AAGCCTCCCGCGTCAATCTGGACCCGCGCGAGCAGAACGATCTGTTGCGCACCATCAACCGCTCTGCGCGCAACCTTCAG
CATCTGCTGAATGATGCGCTCGACATTGCCAAGATCGATGCCGGCAAGCTCGAACTGGCCCCAGCGGCCTTTGACCTGCA
TGAAACGGTTGATGACGTGATGAAGCTGTTCTCGGCCCAGGCCTGCGAGAAAGGCGTTGAGCTGAACCACAGCTTTCGCG
GCATCGAGGCGCAGGAACAGCGCTATGGCGACCGGTTCCGGCTCGCGCAGATCCTTGGCAACCTTTTGAGCAACGCCATC
AAATTCACCGATGACGGAAGCGTATCGCTGCAGATCAATGGCACCCCGGATGCGCTGCATCTCACGCTGCGCGACAGCGG
CTGCGGGATTGCGCCGGACCGTCTCGACAAACTGTTCCTGCCCTACACCCAAGCCAGTGCCGATGTGGCGCAGACCAAGG
GAGGCACGGGCCTTGGTCTGACGATCGTGCACCAGATGGTCGAGCTGATGCAGGGGCGGATCCGCGCCGAGAGCGTGCCC
GGTCGGGGCACCGTCTTTCACCTCTATCTGCCGTTGCCGTTGACCACATCTGCCCCCGAAGCCGAAAAAGTGCATGACCC
GGCAAGGGATGGGATCGGCGACACCGCGCCTGTTGCATCTCCCCCGCCTGCCCCATCCAATGCGCCCTTGTCCGGCAAAC
GGGTGCTCATCGCCGATGACAGCCCGGCCAACCGGCTGGTGCTGCAAAAGATGCTCGAGAACCTCGGCGCGACGGTGGAC
AAGGCCTTTGACGGTGGCGATGCCTTCGGTCGGGCGGTGGCGCGGGCCTATGATGTGTTGCTGCTGGACATCCACATGCC
GGGCCAGACCGGCACCGAGGTGGTCAAGAAGCTGCGCGCGGATCCGCGCCATCAGGCGCATGACGCGCTGTGTATCGCGG
TGACAGGCAGCACCGAAAAGCAAGAGGTCGAGCATTACCTGGACTCGGGTTTTGATGCCTGGATCGGCAAACCGCTGCGC
CAATCCGACCTGATGCGGGTGCTGTCGCCGCTGCTTCTCGAACCCCCGTCCCGCGCGTGA

Upstream 100 bases:

>100_bases
TTCAGTAGAAATTTGCGTATTCAAGGAATGGAATTTACACTCCCTCGCCGGGCGTCCTGCCCGTTTTTGTCCGATGCCCT
GATGTTAAAGATGCTTTGTC

Downstream 100 bases:

>100_bases
GAGCCAAGCCGCCCAGCGGCCAACTCTCTCTTGCAACTGCACAGCGCATGGGCGATCACTGACGCATCCGTATCTTGCCA
TCGCGAGGATGCCGCATCAT

Product: GAF sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MTRAAKLTPDPYDVQLRELGLVQRQPDSDIDNLTRLAAQVLDAPTALVSVVQRSLDRQFFKSCVGLPELSSVLRQTPLSH
SFCQFVQDANQPLIVPDSRNDAQLRDNAAVIDLKMVAYLGVPIHLPDGTPIGALCVIDRVPRQWSSDNLKTLQHLAVAVD
NVIALKHARELAAEAERTAKREAEARKTYLAHMSHEIRTPLNGIIGSVDLLLREASRVNLDPREQNDLLRTINRSARNLQ
HLLNDALDIAKIDAGKLELAPAAFDLHETVDDVMKLFSAQACEKGVELNHSFRGIEAQEQRYGDRFRLAQILGNLLSNAI
KFTDDGSVSLQINGTPDALHLTLRDSGCGIAPDRLDKLFLPYTQASADVAQTKGGTGLGLTIVHQMVELMQGRIRAESVP
GRGTVFHLYLPLPLTTSAPEAEKVHDPARDGIGDTAPVASPPPAPSNAPLSGKRVLIADDSPANRLVLQKMLENLGATVD
KAFDGGDAFGRAVARAYDVLLLDIHMPGQTGTEVVKKLRADPRHQAHDALCIAVTGSTEKQEVEHYLDSGFDAWIGKPLR
QSDLMRVLSPLLLEPPSRA

Sequences:

>Translated_579_residues
MTRAAKLTPDPYDVQLRELGLVQRQPDSDIDNLTRLAAQVLDAPTALVSVVQRSLDRQFFKSCVGLPELSSVLRQTPLSH
SFCQFVQDANQPLIVPDSRNDAQLRDNAAVIDLKMVAYLGVPIHLPDGTPIGALCVIDRVPRQWSSDNLKTLQHLAVAVD
NVIALKHARELAAEAERTAKREAEARKTYLAHMSHEIRTPLNGIIGSVDLLLREASRVNLDPREQNDLLRTINRSARNLQ
HLLNDALDIAKIDAGKLELAPAAFDLHETVDDVMKLFSAQACEKGVELNHSFRGIEAQEQRYGDRFRLAQILGNLLSNAI
KFTDDGSVSLQINGTPDALHLTLRDSGCGIAPDRLDKLFLPYTQASADVAQTKGGTGLGLTIVHQMVELMQGRIRAESVP
GRGTVFHLYLPLPLTTSAPEAEKVHDPARDGIGDTAPVASPPPAPSNAPLSGKRVLIADDSPANRLVLQKMLENLGATVD
KAFDGGDAFGRAVARAYDVLLLDIHMPGQTGTEVVKKLRADPRHQAHDALCIAVTGSTEKQEVEHYLDSGFDAWIGKPLR
QSDLMRVLSPLLLEPPSRA
>Mature_578_residues
TRAAKLTPDPYDVQLRELGLVQRQPDSDIDNLTRLAAQVLDAPTALVSVVQRSLDRQFFKSCVGLPELSSVLRQTPLSHS
FCQFVQDANQPLIVPDSRNDAQLRDNAAVIDLKMVAYLGVPIHLPDGTPIGALCVIDRVPRQWSSDNLKTLQHLAVAVDN
VIALKHARELAAEAERTAKREAEARKTYLAHMSHEIRTPLNGIIGSVDLLLREASRVNLDPREQNDLLRTINRSARNLQH
LLNDALDIAKIDAGKLELAPAAFDLHETVDDVMKLFSAQACEKGVELNHSFRGIEAQEQRYGDRFRLAQILGNLLSNAIK
FTDDGSVSLQINGTPDALHLTLRDSGCGIAPDRLDKLFLPYTQASADVAQTKGGTGLGLTIVHQMVELMQGRIRAESVPG
RGTVFHLYLPLPLTTSAPEAEKVHDPARDGIGDTAPVASPPPAPSNAPLSGKRVLIADDSPANRLVLQKMLENLGATVDK
AFDGGDAFGRAVARAYDVLLLDIHMPGQTGTEVVKKLRADPRHQAHDALCIAVTGSTEKQEVEHYLDSGFDAWIGKPLRQ
SDLMRVLSPLLLEPPSRA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=386, Percent_Identity=33.160621761658, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788713, Length=407, Percent_Identity=32.4324324324324, Blast_Score=169, Evalue=6e-43,
Organism=Escherichia coli, GI1789149, Length=246, Percent_Identity=39.0243902439024, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI87081816, Length=359, Percent_Identity=31.1977715877437, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=34.3096234309623, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=31.0344827586207, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=30.8016877637131, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=272, Percent_Identity=27.2058823529412, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=29.0748898678414, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=255, Percent_Identity=27.4509803921569, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=27.0992366412214, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=25.7510729613734, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=246, Percent_Identity=27.6422764227642, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=24.3727598566308, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63159; Mature: 63028

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAAKLTPDPYDVQLRELGLVQRQPDSDIDNLTRLAAQVLDAPTALVSVVQRSLDRQFF
CCCCCCCCCCCCCHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KSCVGLPELSSVLRQTPLSHSFCQFVQDANQPLIVPDSRNDAQLRDNAAVIDLKMVAYLG
HHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEHHHHHHHC
VPIHLPDGTPIGALCVIDRVPRQWSSDNLKTLQHLAVAVDNVIALKHARELAAEAERTAK
CEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REAEARKTYLAHMSHEIRTPLNGIIGSVDLLLREASRVNLDPREQNDLLRTINRSARNLQ
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HLLNDALDIAKIDAGKLELAPAAFDLHETVDDVMKLFSAQACEKGVELNHSFRGIEAQEQ
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RYGDRFRLAQILGNLLSNAIKFTDDGSVSLQINGTPDALHLTLRDSGCGIAPDRLDKLFL
HCCHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHC
PYTQASADVAQTKGGTGLGLTIVHQMVELMQGRIRAESVPGRGTVFHLYLPLPLTTSAPE
CCHHCCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCCCCCCC
AEKVHDPARDGIGDTAPVASPPPAPSNAPLSGKRVLIADDSPANRLVLQKMLENLGATVD
HHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHH
KAFDGGDAFGRAVARAYDVLLLDIHMPGQTGTEVVKKLRADPRHQAHDALCIAVTGSTEK
HHCCCHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCH
QEVEHYLDSGFDAWIGKPLRQSDLMRVLSPLLLEPPSRA
HHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRAAKLTPDPYDVQLRELGLVQRQPDSDIDNLTRLAAQVLDAPTALVSVVQRSLDRQFF
CCCCCCCCCCCCHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KSCVGLPELSSVLRQTPLSHSFCQFVQDANQPLIVPDSRNDAQLRDNAAVIDLKMVAYLG
HHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEHHHHHHHC
VPIHLPDGTPIGALCVIDRVPRQWSSDNLKTLQHLAVAVDNVIALKHARELAAEAERTAK
CEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REAEARKTYLAHMSHEIRTPLNGIIGSVDLLLREASRVNLDPREQNDLLRTINRSARNLQ
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HLLNDALDIAKIDAGKLELAPAAFDLHETVDDVMKLFSAQACEKGVELNHSFRGIEAQEQ
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
RYGDRFRLAQILGNLLSNAIKFTDDGSVSLQINGTPDALHLTLRDSGCGIAPDRLDKLFL
HCCHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHC
PYTQASADVAQTKGGTGLGLTIVHQMVELMQGRIRAESVPGRGTVFHLYLPLPLTTSAPE
CCHHCCHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCCCCCCC
AEKVHDPARDGIGDTAPVASPPPAPSNAPLSGKRVLIADDSPANRLVLQKMLENLGATVD
HHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHH
KAFDGGDAFGRAVARAYDVLLLDIHMPGQTGTEVVKKLRADPRHQAHDALCIAVTGSTEK
HHCCCHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCH
QEVEHYLDSGFDAWIGKPLRQSDLMRVLSPLLLEPPSRA
HHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7984107 [H]