Click here to switch to the map view.

The map label for this gene is pyrH

Identifier: 99081255

GI number: 99081255

Start: 1507284

End: 1508033

Strand: Reverse

Name: pyrH

Synonym: TM1040_1414

Alternate gene names: 99081255

Gene position: 1508033-1507284 (Counterclockwise)

Preceding gene: 99081262

Following gene: 99081254

Centisome position: 47.11

GC content: 60.27

Gene sequence:

>750_bases
ATGCCCCAGAGCCCAGAGCAGCCGGACGTCTCATCGACCGTAAGTTATAACCGTGTGATGCTGAAAATTTCCGGCGAGGC
CCTTATGGGAACGCAAGGGTTTGGTCTGCATCCGCCGACCGTGCGCAGAATCGCCGAAGAAGTGAAATCTGTGCATGATC
TCGGCGTCGAGATTTGCATGGTGATCGGGGGTGGCAACATCTTTCGCGGGCTTTCGGGCTCGGCACAGGGGATGGAGCGG
ACCACCGCTGACTACATGGGGATGCTCGCAACCGTGATGAACGCGCTGGGGATGCAGTCCGCGCTAGAGGATCTCGGGGT
GTTTACCCGCGTGATCTCGGCCATCCGCATGGATGAGGTCGCAGAGCCCTACATCCGCCGCCGCGCCGTGCGCCACCTGG
AAAAGAAACGGGTCTGCATTTTTGCCGCGGGCACCGGCAACCCCTATTTCACCACCGATACCGCCGCGACCCTGCGCGCC
AATGAGATGAATTGCGAAGCGATCTTTATGGGCAAGAACGGGGTGGACGGGGTCTATGACAAGGACCCCAAAACCAACGA
GGACGCCAAGCGCTATGACAGCGTGAGCTATGACGATGTACTCGCCAAACGCCTGAAGGTCATGGACGCCTCGGCCATCG
CGCTGGCGCGGGACAACAACCTGCCGTTGATTGTCTTTGGCCTGGACGAGCCTGGCGGATTCCGCGGCGTGCTTGCGGGC
GAGGGCACCTATACCAAGGTACACGGTTAA

Upstream 100 bases:

>100_bases
TTAAGAAGATCGGCAATTATCCGGCTGGCCGGATTGATCCTCGGCGGGTTTTGCTTCATTTTGCCGCGAGTTTTAACCCC
GACATATCGCGGAGCGCAAC

Downstream 100 bases:

>100_bases
ACCGGCATCGGGCGAGAACTTGCAGCACGCGCCAACCGCAGAGGCGCGTGTTTTGCGTGCAATTTCACCAAGTTCCGAAG
GTTTCGCGGGTGTTTGTCCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPQSPEQPDVSSTVSYNRVMLKISGEALMGTQGFGLHPPTVRRIAEEVKSVHDLGVEICMVIGGGNIFRGLSGSAQGMER
TTADYMGMLATVMNALGMQSALEDLGVFTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRA
NEMNCEAIFMGKNGVDGVYDKDPKTNEDAKRYDSVSYDDVLAKRLKVMDASAIALARDNNLPLIVFGLDEPGGFRGVLAG
EGTYTKVHG

Sequences:

>Translated_249_residues
MPQSPEQPDVSSTVSYNRVMLKISGEALMGTQGFGLHPPTVRRIAEEVKSVHDLGVEICMVIGGGNIFRGLSGSAQGMER
TTADYMGMLATVMNALGMQSALEDLGVFTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRA
NEMNCEAIFMGKNGVDGVYDKDPKTNEDAKRYDSVSYDDVLAKRLKVMDASAIALARDNNLPLIVFGLDEPGGFRGVLAG
EGTYTKVHG
>Mature_248_residues
PQSPEQPDVSSTVSYNRVMLKISGEALMGTQGFGLHPPTVRRIAEEVKSVHDLGVEICMVIGGGNIFRGLSGSAQGMERT
TADYMGMLATVMNALGMQSALEDLGVFTRVISAIRMDEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRAN
EMNCEAIFMGKNGVDGVYDKDPKTNEDAKRYDSVSYDDVLAKRLKVMDASAIALARDNNLPLIVFGLDEPGGFRGVLAGE
GTYTKVHG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=226, Percent_Identity=46.4601769911504, Blast_Score=212, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_SILST (Q1GGR9)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613409.1
- ProteinModelPortal:   Q1GGR9
- SMR:   Q1GGR9
- STRING:   Q1GGR9
- GeneID:   4078044
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1414
- NMPDR:   fig|292414.1.peg.3482
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   SSP292414:TM1040_1414-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27003; Mature: 26872

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: BINDING 64-64 BINDING 65-65 BINDING 69-69 BINDING 84-84 BINDING 173-173 BINDING 179-179 BINDING 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSPEQPDVSSTVSYNRVMLKISGEALMGTQGFGLHPPTVRRIAEEVKSVHDLGVEICM
CCCCCCCCCCCHHCCEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEE
VIGGGNIFRGLSGSAQGMERTTADYMGMLATVMNALGMQSALEDLGVFTRVISAIRMDEV
EEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMNCEAIFMGKNGVDGVYD
HHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCHHEEEECCCCCEEEEECCCCCCCCCC
KDPKTNEDAKRYDSVSYDDVLAKRLKVMDASAIALARDNNLPLIVFGLDEPGGFRGVLAG
CCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCEEEEEC
EGTYTKVHG
CCCEEEECC
>Mature Secondary Structure 
PQSPEQPDVSSTVSYNRVMLKISGEALMGTQGFGLHPPTVRRIAEEVKSVHDLGVEICM
CCCCCCCCCCHHCCEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEE
VIGGGNIFRGLSGSAQGMERTTADYMGMLATVMNALGMQSALEDLGVFTRVISAIRMDEV
EEECCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMNCEAIFMGKNGVDGVYD
HHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCCHHEEEECCCCCEEEEECCCCCCCCCC
KDPKTNEDAKRYDSVSYDDVLAKRLKVMDASAIALARDNNLPLIVFGLDEPGGFRGVLAG
CCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCEEEEEC
EGTYTKVHG
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA