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The map label for this gene is livH [H]

Identifier: 99081116

GI number: 99081116

Start: 1373500

End: 1374510

Strand: Direct

Name: livH [H]

Synonym: TM1040_1275

Alternate gene names: 99081116

Gene position: 1373500-1374510 (Clockwise)

Preceding gene: 99081115

Following gene: 99081117

Centisome position: 42.91

GC content: 55.69

Gene sequence:

>1011_bases
ATGGATTTCCTCAATGCCTTCGTGGCGCTTTCAAACTTTGTTCTGATCCCCGGCATCGCCTATGGCAGCCAACTGGCGCT
TGGCGCACTTGGGGTGACGCTGATCTACGGGATCTTGCGCTTTTCGAACTTTGCCCATGGGGACACCATGGCCTTTGGGA
CCATGGTCGTGATCCTGTTTACTTGGCTGTTCCAGTCCTGGGGCATCTCCGCAGGCCCGCTGCCAACCGCGCTTCTGGCG
TTGCCAATCGGGATCGTGATGACCATGGGGTTGGTTCTGATCACCGACAAGGCCGTGTTCAAATTCTACCGCGAGCAAAA
AGCAAAGCCCGTGGTCTTTGTGATGGTCTCGCTTGGCGTGATGTTCATGATGAACGGGCTTGTGCGCTTTATCATCGGTC
CCGGCGATCAGCGGTTTGGTGATGGCGAGCGGTTCATCATCAAGGCCCGCACCTTCAAGCAGATGACCGGTCTTGATGAG
GGTCTAGCAATCAAGACCTCGCAGGGCATCACCGTGGTCACAGCCATTGTTGTGGTGGCGCTGTTGTTCTGGTTCCTCAA
CAAGACCCGAACGGGCAAATCCATGCGCGCCTATTCCGACAACGAGGATCTGGCGCTGTTGTCTGGCATCAATCCCGAAC
GCGTGGTCATGATCACATGGATCATCGTCGCAGCACTGGCGACCATTGCCGGCACGCTATACGGGCTTGATAAGTCATTC
AAACCTTTCACTTATTTCCAGCTTCTCCTGCCGATCTTTGCGGCGGCCATCGTGGGCGGTCTCGGCAGCCCTCTGGGCGC
AATCGCTGGTGGGTTTGTCATCGCCATGAGCGAGGTGATGATCACCTACGCTTGGAAAAAAGTGGGCGGTTACCTGCTGC
CTGAAAGCCTGGAACCAGAGGGGCTCGCACAGCTTCTGAGCACGGATTACAAATTTGCGGTTTCCTTTGCGATCCTCGTC
GTTGTGCTGCTGTTCAAACCCACCGGTATCTTCAAAGGAAAAGCGGTATGA

Upstream 100 bases:

>100_bases
AGGCTATGTCCTCGTTCAAGGCGCGAACGCCTATACGGGCACCGGTCAGGAACTGCTGGCCGATCCCGAAGTACGCAAAT
CTTTCCTGGGAGGCTAAGAG

Downstream 100 bases:

>100_bases
GCGATACGTTGAAACATACGCTTCTGTTCGCCTTCGTCGGCCTGTTGCTGGTGCTCGAGGGGACCACAAATGCGTTTGGC
GTTTTCTCGGGATCGTGGAA

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDFLNAFVALSNFVLIPGIAYGSQLALGALGVTLIYGILRFSNFAHGDTMAFGTMVVILFTWLFQSWGISAGPLPTALLA
LPIGIVMTMGLVLITDKAVFKFYREQKAKPVVFVMVSLGVMFMMNGLVRFIIGPGDQRFGDGERFIIKARTFKQMTGLDE
GLAIKTSQGITVVTAIVVVALLFWFLNKTRTGKSMRAYSDNEDLALLSGINPERVVMITWIIVAALATIAGTLYGLDKSF
KPFTYFQLLLPIFAAAIVGGLGSPLGAIAGGFVIAMSEVMITYAWKKVGGYLLPESLEPEGLAQLLSTDYKFAVSFAILV
VVLLFKPTGIFKGKAV

Sequences:

>Translated_336_residues
MDFLNAFVALSNFVLIPGIAYGSQLALGALGVTLIYGILRFSNFAHGDTMAFGTMVVILFTWLFQSWGISAGPLPTALLA
LPIGIVMTMGLVLITDKAVFKFYREQKAKPVVFVMVSLGVMFMMNGLVRFIIGPGDQRFGDGERFIIKARTFKQMTGLDE
GLAIKTSQGITVVTAIVVVALLFWFLNKTRTGKSMRAYSDNEDLALLSGINPERVVMITWIIVAALATIAGTLYGLDKSF
KPFTYFQLLLPIFAAAIVGGLGSPLGAIAGGFVIAMSEVMITYAWKKVGGYLLPESLEPEGLAQLLSTDYKFAVSFAILV
VVLLFKPTGIFKGKAV
>Mature_336_residues
MDFLNAFVALSNFVLIPGIAYGSQLALGALGVTLIYGILRFSNFAHGDTMAFGTMVVILFTWLFQSWGISAGPLPTALLA
LPIGIVMTMGLVLITDKAVFKFYREQKAKPVVFVMVSLGVMFMMNGLVRFIIGPGDQRFGDGERFIIKARTFKQMTGLDE
GLAIKTSQGITVVTAIVVVALLFWFLNKTRTGKSMRAYSDNEDLALLSGINPERVVMITWIIVAALATIAGTLYGLDKSF
KPFTYFQLLLPIFAAAIVGGLGSPLGAIAGGFVIAMSEVMITYAWKKVGGYLLPESLEPEGLAQLLSTDYKFAVSFAILV
VVLLFKPTGIFKGKAV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=321, Percent_Identity=27.4143302180685, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 36316; Mature: 36316

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLNAFVALSNFVLIPGIAYGSQLALGALGVTLIYGILRFSNFAHGDTMAFGTMVVILF
CHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TWLFQSWGISAGPLPTALLALPIGIVMTMGLVLITDKAVFKFYREQKAKPVVFVMVSLGV
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MFMMNGLVRFIIGPGDQRFGDGERFIIKARTFKQMTGLDEGLAIKTSQGITVVTAIVVVA
HHHHHHHHHEEECCCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHH
LLFWFLNKTRTGKSMRAYSDNEDLALLSGINPERVVMITWIIVAALATIAGTLYGLDKSF
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
KPFTYFQLLLPIFAAAIVGGLGSPLGAIAGGFVIAMSEVMITYAWKKVGGYLLPESLEPE
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHH
GLAQLLSTDYKFAVSFAILVVVLLFKPTGIFKGKAV
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDFLNAFVALSNFVLIPGIAYGSQLALGALGVTLIYGILRFSNFAHGDTMAFGTMVVILF
CHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
TWLFQSWGISAGPLPTALLALPIGIVMTMGLVLITDKAVFKFYREQKAKPVVFVMVSLGV
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
MFMMNGLVRFIIGPGDQRFGDGERFIIKARTFKQMTGLDEGLAIKTSQGITVVTAIVVVA
HHHHHHHHHEEECCCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHH
LLFWFLNKTRTGKSMRAYSDNEDLALLSGINPERVVMITWIIVAALATIAGTLYGLDKSF
HHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
KPFTYFQLLLPIFAAAIVGGLGSPLGAIAGGFVIAMSEVMITYAWKKVGGYLLPESLEPE
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHH
GLAQLLSTDYKFAVSFAILVVVLLFKPTGIFKGKAV
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]