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The map label for this gene is gmk

Identifier: 99081107

GI number: 99081107

Start: 1363877

End: 1364530

Strand: Reverse

Name: gmk

Synonym: TM1040_1266

Alternate gene names: 99081107

Gene position: 1364530-1363877 (Counterclockwise)

Preceding gene: 99081108

Following gene: 99081106

Centisome position: 42.63

GC content: 59.79

Gene sequence:

>654_bases
ATGGCACATTCAAAAGCGCAGCGACGGGGTCTTCTCATCATCCTGTCCTCCCCCTCCGGTGCAGGCAAATCCACCCTCGC
CAAGCGGCTGCGGGCCTGGGACAGCGACATCAGCTTTTCGGTCTCGGCCACGACGCGCAAGCCCCGCCCGGGCGAGGTCG
ATGGGCAGGACTATCATTTTGTCACGGTCGAGTCGTTCAAACAGGACGTGGCCAATGGCGATATGCTCGAACACGCCCAT
GTGTTCGGGAATTTCTACGGCTCTCCGAAGGGGCCGGTTCAGACAGCCATCAACGAAGGCCGCGATGTGCTCTTTGACAT
CGACTGGCAGGGCGCGCAGCAGATCACCAATTCGGATCTCGGCAAACACACGCTGTCGATCTTTTTGTTGCCGCCCTCCA
TTACCGAGCTGCGCCGCCGCCTCGAAAGCCGTGGTCAGGACGACGCGGAAACCATCAGCCGTCGCATGCAAAAGAGCTGG
GACGAGATCTCGCACTGGGGGTCCTATGATCATGTGCTGATCAACGAGGATCTCGATGAGACCGAAGAAGCCTTGAAGAC
GATCATCACCGCCACCCGCCTGCGCCGCATTCAACAGCCGTCGCTCATCGAACACGCACGCGCCCTGCAGCAGGAATTTG
AGGACCTGTCATGA

Upstream 100 bases:

>100_bases
GCAGAACGCGGCCTTGACCGAAGTGGGTTTGGAACTCAAAACCGTGATCGACCAGATGCGCGAGCAGGTTCAGAACATAG
AATAAGGAGAACTCCCTAAC

Downstream 100 bases:

>100_bases
CCCTCTACGCCCTAGGAGAAGACCGCCCCCAGATCCATGCCGACACATGGGTCGCGCCTGACGCAAATCTCATTGGCAAA
GTGGTGCTGGAAGAGGGGGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MAHSKAQRRGLLIILSSPSGAGKSTLAKRLRAWDSDISFSVSATTRKPRPGEVDGQDYHFVTVESFKQDVANGDMLEHAH
VFGNFYGSPKGPVQTAINEGRDVLFDIDWQGAQQITNSDLGKHTLSIFLLPPSITELRRRLESRGQDDAETISRRMQKSW
DEISHWGSYDHVLINEDLDETEEALKTIITATRLRRIQQPSLIEHARALQQEFEDLS

Sequences:

>Translated_217_residues
MAHSKAQRRGLLIILSSPSGAGKSTLAKRLRAWDSDISFSVSATTRKPRPGEVDGQDYHFVTVESFKQDVANGDMLEHAH
VFGNFYGSPKGPVQTAINEGRDVLFDIDWQGAQQITNSDLGKHTLSIFLLPPSITELRRRLESRGQDDAETISRRMQKSW
DEISHWGSYDHVLINEDLDETEEALKTIITATRLRRIQQPSLIEHARALQQEFEDLS
>Mature_216_residues
AHSKAQRRGLLIILSSPSGAGKSTLAKRLRAWDSDISFSVSATTRKPRPGEVDGQDYHFVTVESFKQDVANGDMLEHAHV
FGNFYGSPKGPVQTAINEGRDVLFDIDWQGAQQITNSDLGKHTLSIFLLPPSITELRRRLESRGQDDAETISRRMQKSWD
EISHWGSYDHVLINEDLDETEEALKTIITATRLRRIQQPSLIEHARALQQEFEDLS

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=182, Percent_Identity=42.3076923076923, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI226874833, Length=182, Percent_Identity=42.3076923076923, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI4504221, Length=182, Percent_Identity=42.3076923076923, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI38570142, Length=193, Percent_Identity=33.160621761658, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI21361598, Length=202, Percent_Identity=27.2277227722772, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI14780902, Length=197, Percent_Identity=27.4111675126904, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI52630447, Length=195, Percent_Identity=26.1538461538462, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1790080, Length=193, Percent_Identity=48.7046632124352, Blast_Score=183, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=37.2093023255814, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=37.2093023255814, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=27.6243093922652, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=141, Percent_Identity=34.0425531914894, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=40.5405405405405, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.9120879120879, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45554481, Length=169, Percent_Identity=28.4023668639053, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI85724806, Length=169, Percent_Identity=28.4023668639053, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=28.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45554489, Length=169, Percent_Identity=28.4023668639053, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640542, Length=169, Percent_Identity=28.4023668639053, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077626, Length=169, Percent_Identity=28.4023668639053, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_SILST (Q1GH67)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613261.1
- ProteinModelPortal:   Q1GH67
- STRING:   Q1GH67
- GeneID:   4077660
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1266
- NMPDR:   fig|292414.1.peg.3603
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q1GH67
- ProtClustDB:   PRK00300
- BioCyc:   SSP292414:TM1040_1266-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24497; Mature: 24365

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSKAQRRGLLIILSSPSGAGKSTLAKRLRAWDSDISFSVSATTRKPRPGEVDGQDYHF
CCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEE
VTVESFKQDVANGDMLEHAHVFGNFYGSPKGPVQTAINEGRDVLFDIDWQGAQQITNSDL
EEHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHCCC
GKHTLSIFLLPPSITELRRRLESRGQDDAETISRRMQKSWDEISHWGSYDHVLINEDLDE
CCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
TEEALKTIITATRLRRIQQPSLIEHARALQQEFEDLS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AHSKAQRRGLLIILSSPSGAGKSTLAKRLRAWDSDISFSVSATTRKPRPGEVDGQDYHF
CCCCHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEE
VTVESFKQDVANGDMLEHAHVFGNFYGSPKGPVQTAINEGRDVLFDIDWQGAQQITNSDL
EEHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHCCC
GKHTLSIFLLPPSITELRRRLESRGQDDAETISRRMQKSWDEISHWGSYDHVLINEDLDE
CCEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCH
TEEALKTIITATRLRRIQQPSLIEHARALQQEFEDLS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA