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The map label for this gene is pdhA [H]

Identifier: 99080920

GI number: 99080920

Start: 1155145

End: 1156158

Strand: Reverse

Name: pdhA [H]

Synonym: TM1040_1079

Alternate gene names: 99080920

Gene position: 1156158-1155145 (Counterclockwise)

Preceding gene: 99080921

Following gene: 99080919

Centisome position: 36.12

GC content: 60.16

Gene sequence:

>1014_bases
ATGGCCGCAAGAAAAAGCGCTCAGAAATCAAATGTTTCCGCCGAAGAACTGACCAAGTACTACCGCGAAATGCTGTTGAT
CCGGCGATTCGAGGAAAAGGCGGGTCAGCTCTACGGCATGGGGTTGATTGGCGGTTTCTGCCACCTCTACATCGGTCAGG
AAGCCGTTGTGGTCGGCCTTGAGGCCGCCGCAGAAGAAGGCGACAAACGCGTCACCTCATATCGCGACCACGGGCACATG
CTCGCCTGCGGCATGGATGCCGGCGGCGTGATGGCCGAACTCACCGGTCGCGAGGGCGGCTACTCCAAGGGCAAGGGCGG
CTCCATGCACATGTTCTCCAAGGAGAAGCATTTCTATGGTGGCCACGGCATCGTCGGCGCGCAGGTGCCGCTCGGCGCAG
GCCTTGCCTTTTCCGACAAATACAAGGGCAACGACCGCGTGACCTTCACCTATTTTGGCGATGGCGCGGCGAACCAGGGC
CAGGTCTACGAGACCTACAACATGGCGCAGCTCTGGGATCTGCCGGTGATTTTTGTCATTGAAAATAACCAATACGCCAT
GGGCACGAGCGTCCAGCGCTCCACCAAGTCGCCCGCGCTCTGGAAGCGCGGCGAGGCCTACGGCATCAAGGGCGAAGAAG
TGGACGGCATGAACGTTCTGGCCGTGAAAGAGGCCGGCGAGCGCGCCGTGGCCCACTGCCGCGCGGGCAAGGGTCCCTAT
ATCCTCGAGGTCAAAACCTACCGCTATCGCGGCCACTCCATGTCGGACCCGGCGAAATACCGGACCCGCGAGGAAGTGCA
GAAAATGCGCGAGGAACGCGATCCGATCGAACAGGTCCGCGAGATGCTGCTCACCGGCAAGCACGCCTCCGAGGAAGACC
TCAAAGCCATCGACAAAGAGATCAAGGATATCGTCAACAAGTCCGCTGATTTCGCCAAAGAGAGCCCCGAGCCCGCGCTC
GAGGAGCTTTGGACCGATATTTACGCCGACGATATTCCGCAAAAGAGCGCCTGA

Upstream 100 bases:

>100_bases
ATTTCAACTGCTTCGAGATTATCCCTCGCATGCTGGAGCAAAATACACTATGAGATAGTTTAGTGTTAAACTACCTAAGC
TTTAGGGGGAGCAAGCCGTT

Downstream 100 bases:

>100_bases
GGGGAGAGACTGAGACTATGGCAACTGAAATTCTGATGCCCGCCCTGTCGCCGACCATGGAGGAAGGCACACTGGCCAAA
TGGCTGGTCAAGGAAGGCGA

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAARKSAQKSNVSAEELTKYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRVTSYRDHGHM
LACGMDAGGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVGAQVPLGAGLAFSDKYKGNDRVTFTYFGDGAANQG
QVYETYNMAQLWDLPVIFVIENNQYAMGTSVQRSTKSPALWKRGEAYGIKGEEVDGMNVLAVKEAGERAVAHCRAGKGPY
ILEVKTYRYRGHSMSDPAKYRTREEVQKMREERDPIEQVREMLLTGKHASEEDLKAIDKEIKDIVNKSADFAKESPEPAL
EELWTDIYADDIPQKSA

Sequences:

>Translated_337_residues
MAARKSAQKSNVSAEELTKYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRVTSYRDHGHM
LACGMDAGGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVGAQVPLGAGLAFSDKYKGNDRVTFTYFGDGAANQG
QVYETYNMAQLWDLPVIFVIENNQYAMGTSVQRSTKSPALWKRGEAYGIKGEEVDGMNVLAVKEAGERAVAHCRAGKGPY
ILEVKTYRYRGHSMSDPAKYRTREEVQKMREERDPIEQVREMLLTGKHASEEDLKAIDKEIKDIVNKSADFAKESPEPAL
EELWTDIYADDIPQKSA
>Mature_336_residues
AARKSAQKSNVSAEELTKYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGLEAAAEEGDKRVTSYRDHGHML
ACGMDAGGVMAELTGREGGYSKGKGGSMHMFSKEKHFYGGHGIVGAQVPLGAGLAFSDKYKGNDRVTFTYFGDGAANQGQ
VYETYNMAQLWDLPVIFVIENNQYAMGTSVQRSTKSPALWKRGEAYGIKGEEVDGMNVLAVKEAGERAVAHCRAGKGPYI
LEVKTYRYRGHSMSDPAKYRTREEVQKMREERDPIEQVREMLLTGKHASEEDLKAIDKEIKDIVNKSADFAKESPEPALE
ELWTDIYADDIPQKSA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=314, Percent_Identity=54.7770700636943, Blast_Score=350, Evalue=8e-97,
Organism=Homo sapiens, GI291084742, Length=323, Percent_Identity=53.8699690402477, Blast_Score=331, Evalue=5e-91,
Organism=Homo sapiens, GI4505685, Length=323, Percent_Identity=53.8699690402477, Blast_Score=331, Evalue=6e-91,
Organism=Homo sapiens, GI291084744, Length=330, Percent_Identity=52.7272727272727, Blast_Score=324, Evalue=6e-89,
Organism=Homo sapiens, GI291084757, Length=323, Percent_Identity=47.6780185758514, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI11386135, Length=325, Percent_Identity=29.5384615384615, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI258645172, Length=325, Percent_Identity=29.5384615384615, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=50.920245398773, Blast_Score=326, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=50.920245398773, Blast_Score=325, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI86563357, Length=329, Percent_Identity=29.1793313069909, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI86563355, Length=329, Percent_Identity=29.1793313069909, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=320, Percent_Identity=48.75, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24639740, Length=330, Percent_Identity=48.7878787878788, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24639744, Length=330, Percent_Identity=48.7878787878788, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI28571106, Length=330, Percent_Identity=48.7878787878788, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=50.1597444089457, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24639748, Length=325, Percent_Identity=48.6153846153846, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI21355903, Length=327, Percent_Identity=26.605504587156, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37382; Mature: 37251

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARKSAQKSNVSAEELTKYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGL
CCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCEEEEEH
EAAAEEGDKRVTSYRDHGHMLACGMDAGGVMAELTGREGGYSKGKGGSMHMFSKEKHFYG
HHHHHCCHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCEEC
GHGIVGAQVPLGAGLAFSDKYKGNDRVTFTYFGDGAANQGQVYETYNMAQLWDLPVIFVI
CCCEEECCCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHCCCEEEEE
ENNQYAMGTSVQRSTKSPALWKRGEAYGIKGEEVDGMNVLAVKEAGERAVAHCRAGKGPY
ECCCEEECCCHHHCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCE
ILEVKTYRYRGHSMSDPAKYRTREEVQKMREERDPIEQVREMLLTGKHASEEDLKAIDKE
EEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHH
IKDIVNKSADFAKESPEPALEELWTDIYADDIPQKSA
HHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AARKSAQKSNVSAEELTKYYREMLLIRRFEEKAGQLYGMGLIGGFCHLYIGQEAVVVGL
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCEEEEEH
EAAAEEGDKRVTSYRDHGHMLACGMDAGGVMAELTGREGGYSKGKGGSMHMFSKEKHFYG
HHHHHCCHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCEEC
GHGIVGAQVPLGAGLAFSDKYKGNDRVTFTYFGDGAANQGQVYETYNMAQLWDLPVIFVI
CCCEEECCCCCCCCCEECCCCCCCCEEEEEEECCCCCCCCCEEEECCHHHHHCCCEEEEE
ENNQYAMGTSVQRSTKSPALWKRGEAYGIKGEEVDGMNVLAVKEAGERAVAHCRAGKGPY
ECCCEEECCCHHHCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCE
ILEVKTYRYRGHSMSDPAKYRTREEVQKMREERDPIEQVREMLLTGKHASEEDLKAIDKE
EEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHH
IKDIVNKSADFAKESPEPALEELWTDIYADDIPQKSA
HHHHHHCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]