Click here to switch to the map view.

The map label for this gene is hmrR [H]

Identifier: 99080378

GI number: 99080378

Start: 569385

End: 569786

Strand: Direct

Name: hmrR [H]

Synonym: TM1040_0537

Alternate gene names: 99080378

Gene position: 569385-569786 (Clockwise)

Preceding gene: 99080376

Following gene: 99080379

Centisome position: 17.79

GC content: 56.22

Gene sequence:

>402_bases
ATGAATATCGGTGACGTAGCGGCGAAGTCGGGACTTCCGGCCAAGACGATCCGCTATTACGAGGACATCGGTCTGATCTG
TCCCAACCGTAGTGCCAATGGTTATCGCTGTTTTGAGGAGAGGGATCTCCACAAGCTGGCCTTTTTGGGGCGTGCTCGGG
CGCTGGGGTTTTCGATAGAGGACTGCCGTGTCCTGCTTGGACTCTACGAGGACGACAGCCGCGCCAGTGCGGATGTAAAA
CAGCTTGCGCAGGCACATTTGTGCAAGATCGAAGCAAAGATCAGCGATCTGGCGGCGATGCGTGAAACCCTCAGCGAATT
GATCACCTGCTGCTCTGGCGACAATCGTCCTGACTGCCCGATCCTCAAGGATCTGTCCGGCGAAACCGATCCGATTGGAT
GA

Upstream 100 bases:

>100_bases
TCTTTGCAGCGGACGACTTGAGATTGCTTGCAGTCGTCTCCATCTTGGGGAAGATGATGTAGTAAGCTTAGCGCAAGCGA
TGTCTGGGAGGCGTGGACAG

Downstream 100 bases:

>100_bases
TCAGGCAGGCTATCCCGAAGATCAAACCCTGACAGAAGGCACAATCAAGGCTTGATGGGCAATCCTTGGGGCCGAGAGGC
GCGGCGCGCTTACCTGAAAA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MNIGDVAAKSGLPAKTIRYYEDIGLICPNRSANGYRCFEERDLHKLAFLGRARALGFSIEDCRVLLGLYEDDSRASADVK
QLAQAHLCKIEAKISDLAAMRETLSELITCCSGDNRPDCPILKDLSGETDPIG

Sequences:

>Translated_133_residues
MNIGDVAAKSGLPAKTIRYYEDIGLICPNRSANGYRCFEERDLHKLAFLGRARALGFSIEDCRVLLGLYEDDSRASADVK
QLAQAHLCKIEAKISDLAAMRETLSELITCCSGDNRPDCPILKDLSGETDPIG
>Mature_133_residues
MNIGDVAAKSGLPAKTIRYYEDIGLICPNRSANGYRCFEERDLHKLAFLGRARALGFSIEDCRVLLGLYEDDSRASADVK
QLAQAHLCKIEAKISDLAAMRETLSELITCCSGDNRPDCPILKDLSGETDPIG

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=128, Percent_Identity=44.53125, Blast_Score=115, Evalue=1e-27,
Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=34.375, Blast_Score=72, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14565; Mature: 14565

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGDVAAKSGLPAKTIRYYEDIGLICPNRSANGYRCFEERDLHKLAFLGRARALGFSIE
CCCCHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCCHH
DCRVLLGLYEDDSRASADVKQLAQAHLCKIEAKISDLAAMRETLSELITCCSGDNRPDCP
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILKDLSGETDPIG
HHHCCCCCCCCCC
>Mature Secondary Structure
MNIGDVAAKSGLPAKTIRYYEDIGLICPNRSANGYRCFEERDLHKLAFLGRARALGFSIE
CCCCHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCCHH
DCRVLLGLYEDDSRASADVKQLAQAHLCKIEAKISDLAAMRETLSELITCCSGDNRPDCP
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILKDLSGETDPIG
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]