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The map label for this gene is fdhB1 [H]

Identifier: 99080243

GI number: 99080243

Start: 411594

End: 412187

Strand: Direct

Name: fdhB1 [H]

Synonym: TM1040_0402

Alternate gene names: 99080243

Gene position: 411594-412187 (Clockwise)

Preceding gene: 99080242

Following gene: 99080244

Centisome position: 12.86

GC content: 59.6

Gene sequence:

>594_bases
ATGTCAAGAGCAAAGTTCCTCTGTGACGCCGAACGCTGCATCGAGTGCAACGCCTGTGTCACCGCTTGTAAGAACGAGCA
TGAAGTCCCCTGGGGCATCAACCGTCGCCGTGTTGTGACCATCAACGATGGTAAGCCCGGCGAACGCTCGATCTCGGTCG
CCTGCATGCATTGTTCCGATGCTCCCTGCATGGCGGTCTGTCCGGTAGACTGTTTCTACCAGACCGAGGATGGGGTGGTT
CTCCACTCCAAGGACCTCTGCATCGGCTGTGGGTACTGCTTCTATGCATGTCCCTTTGGCGCGCCGCAGTTCCCGCAGGC
GGGTAACTTCGGATCTCGTGGCAAGATGGACAAATGTACCTTCTGTGCAGGCGGTCCCGAGGAGAACAACTCTCAGGCGG
AGTTCCAGAAATACGGGCGCAACCGGATTGCAGAAGGCAAGTTGCCGATCTGCGCCGAGATGTGCTCCACCAAGGCGCTT
CTTGCGGGCGATGGCGATACCGTTTCGTCGATCTACCGCGAGCGCGTGGTGGCCCGTGGCTTTGGTTCCGGCGCCTGGGG
TTGGGGCACGGCCTACGATCAGAAAGGCGGCTAA

Upstream 100 bases:

>100_bases
ACCAACACCGCGCAGACCTACGGCTATGACTCTGTCACGCAGATGCAAGAGACCAAAGCCACCCTCTGCAAAATCTCAGC
AGCCTAAGGAGTAGAGAAAC

Downstream 100 bases:

>100_bases
CGCCTCCTTTTGATCCCAAAACGCCTACAACGGGAGGCGGCCCGCCGTTTGGCGGGCCCCTTCCGCTATACGAATAATTC
ATCTTAACAAATCCGGCTCA

Product: 4Fe-4S ferredoxin, iron-sulfur binding

Products: CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSRAKFLCDAERCIECNACVTACKNEHEVPWGINRRRVVTINDGKPGERSISVACMHCSDAPCMAVCPVDCFYQTEDGVV
LHSKDLCIGCGYCFYACPFGAPQFPQAGNFGSRGKMDKCTFCAGGPEENNSQAEFQKYGRNRIAEGKLPICAEMCSTKAL
LAGDGDTVSSIYRERVVARGFGSGAWGWGTAYDQKGG

Sequences:

>Translated_197_residues
MSRAKFLCDAERCIECNACVTACKNEHEVPWGINRRRVVTINDGKPGERSISVACMHCSDAPCMAVCPVDCFYQTEDGVV
LHSKDLCIGCGYCFYACPFGAPQFPQAGNFGSRGKMDKCTFCAGGPEENNSQAEFQKYGRNRIAEGKLPICAEMCSTKAL
LAGDGDTVSSIYRERVVARGFGSGAWGWGTAYDQKGG
>Mature_196_residues
SRAKFLCDAERCIECNACVTACKNEHEVPWGINRRRVVTINDGKPGERSISVACMHCSDAPCMAVCPVDCFYQTEDGVVL
HSKDLCIGCGYCFYACPFGAPQFPQAGNFGSRGKMDKCTFCAGGPEENNSQAEFQKYGRNRIAEGKLPICAEMCSTKALL
AGDGDTVSSIYRERVVARGFGSGAWGWGTAYDQKGG

Specific function: This chain is an electron transfer unit containing 18 cysteine residues, 16 of which occur in four clusters [H]

COG id: COG0437

COG function: function code C; Fe-S-cluster-containing hydrogenase components 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Escherichia coli, GI1787122, Length=174, Percent_Identity=33.9080459770115, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787872, Length=169, Percent_Identity=34.3195266272189, Blast_Score=95, Evalue=2e-21,
Organism=Escherichia coli, GI226510944, Length=170, Percent_Identity=34.1176470588235, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367345, Length=189, Percent_Identity=34.9206349206349, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789370, Length=198, Percent_Identity=28.2828282828283, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790326, Length=202, Percent_Identity=27.7227722772277, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082114, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787749, Length=199, Percent_Identity=27.1356783919598, Blast_Score=67, Evalue=5e-13,
Organism=Escherichia coli, GI2367245, Length=180, Percent_Identity=31.1111111111111, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789079, Length=201, Percent_Identity=27.8606965174129, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87082180, Length=187, Percent_Identity=30.4812834224599, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788811, Length=127, Percent_Identity=30.7086614173228, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR000813 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: 1.2.1.2

Molecular weight: Translated: 21318; Mature: 21187

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

9.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
11.7 %Cys+Met (Translated Protein)
9.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
11.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAKFLCDAERCIECNACVTACKNEHEVPWGINRRRVVTINDGKPGERSISVACMHCSD
CCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCC
APCMAVCPVDCFYQTEDGVVLHSKDLCIGCGYCFYACPFGAPQFPQAGNFGSRGKMDKCT
CCEEEECCCEEEEECCCCEEEECCCCEEECCHHHEECCCCCCCCCCCCCCCCCCCCCCEE
FCAGGPEENNSQAEFQKYGRNRIAEGKLPICAEMCSTKALLAGDGDTVSSIYRERVVARG
EECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHHC
FGSGAWGWGTAYDQKGG
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SRAKFLCDAERCIECNACVTACKNEHEVPWGINRRRVVTINDGKPGERSISVACMHCSD
CCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCC
APCMAVCPVDCFYQTEDGVVLHSKDLCIGCGYCFYACPFGAPQFPQAGNFGSRGKMDKCT
CCEEEECCCEEEEECCCCEEEECCCCEEECCHHHEECCCCCCCCCCCCCCCCCCCCCCEE
FCAGGPEENNSQAEFQKYGRNRIAEGKLPICAEMCSTKALLAGDGDTVSSIYRERVVARG
EECCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHHC
FGSGAWGWGTAYDQKGG
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate; NAD+

Specific reaction: formate + NAD+ = CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1781728; 14500908 [H]