Click here to switch to the map view.

The map label for this gene is argB

Identifier: 99080142

GI number: 99080142

Start: 307007

End: 307867

Strand: Reverse

Name: argB

Synonym: TM1040_0301

Alternate gene names: 99080142

Gene position: 307867-307007 (Counterclockwise)

Preceding gene: 99080144

Following gene: 99080141

Centisome position: 9.62

GC content: 64.0

Gene sequence:

>861_bases
ATGAAGACCAGAGACATGAACCGCGACTGGATTGCCACTGCCGAAACCCTCTCAAGCGCCCTGCCCTACCTGCAGCGCTA
TGACGACGCCATCGTGGTCATCAAGCTCGGCGGTCACGCCATGGGCAGCGACGAAGGCATGGAGAGCTTTGCCCGCGACG
TGGTGCTTCTACGTCAGGTGGGCGTGAACCCGGTGATCGTGCATGGCGGCGGGCCGATGATCAACGCGCTGCTCGACAAG
CTGCAGATCAAGTCCGAATTCGTGAACGGCAAGCGCGTCACCGACGCAGCCACCATGGAAGTGGTGGAGATGGTGCTCTC
CGGCATGGTCAACAAGCGCATCGTGCAGGCGATCAACGCCCAGGGCGGCAAGGGGATTGGCCTGTCGGGCAAAGACGCCA
ACCTCATCACCTGCGAGGCAACCGATCCCGCACTTGGCTTCGTGGGCACCCCTTCCGAGGTGAACGCCGACATGCTGAAG
AACCTCTTTGAAAAAGAGTTCATCCCCGTGATTGCCCCCATCGGCTCCGGGACGGCCGGCGAAACCTTCAACATCAACGG
CGACACCGCCGCAGGCGCCGTGGCCGCCGCACTCAAGGCCGACCGGCTCTTGCTGCTGACGGATGTGGCCGGTGTGAAGA
ACGCCGAAGGTGTGGTCGTGACCGAGCTCAAGGCCGCCGATGTGGAGGAAATGACCGCCGCGGGCGTGATCGCCGGTGGT
ATGATTCCCAAGACCGAGACCGCTCTGGCCGCCGTCCGCGGCGGGGTGCGCGCCTGCACCATCGTCGACGGACGCGTGCC
CAACGCGGTCCTGTTGGAGCTGTTCACGGATCACGGCGCAGGCTCGATGATCCGCAGCTGA

Upstream 100 bases:

>100_bases
GAGCGCTGCAACCAGATCCTGCTTGGCAGGCGGGCCGGAAATGCGTAACACCGATGGAACACTTCGCCCCGGCATCCCCC
GAGGCCTCAGGACCAGACAG

Downstream 100 bases:

>100_bases
TCCTCAGCTGATGCGCTGTATTGGTCCCGGGCGTCTCGGGACCACGACCCGGCCGATACAAATGCCCCGCGCAGCCCTTG
TCTGCGCGCAGGCTTGCCAG

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKTRDMNRDWIATAETLSSALPYLQRYDDAIVVIKLGGHAMGSDEGMESFARDVVLLRQVGVNPVIVHGGGPMINALLDK
LQIKSEFVNGKRVTDAATMEVVEMVLSGMVNKRIVQAINAQGGKGIGLSGKDANLITCEATDPALGFVGTPSEVNADMLK
NLFEKEFIPVIAPIGSGTAGETFNINGDTAAGAVAAALKADRLLLLTDVAGVKNAEGVVVTELKAADVEEMTAAGVIAGG
MIPKTETALAAVRGGVRACTIVDGRVPNAVLLELFTDHGAGSMIRS

Sequences:

>Translated_286_residues
MKTRDMNRDWIATAETLSSALPYLQRYDDAIVVIKLGGHAMGSDEGMESFARDVVLLRQVGVNPVIVHGGGPMINALLDK
LQIKSEFVNGKRVTDAATMEVVEMVLSGMVNKRIVQAINAQGGKGIGLSGKDANLITCEATDPALGFVGTPSEVNADMLK
NLFEKEFIPVIAPIGSGTAGETFNINGDTAAGAVAAALKADRLLLLTDVAGVKNAEGVVVTELKAADVEEMTAAGVIAGG
MIPKTETALAAVRGGVRACTIVDGRVPNAVLLELFTDHGAGSMIRS
>Mature_286_residues
MKTRDMNRDWIATAETLSSALPYLQRYDDAIVVIKLGGHAMGSDEGMESFARDVVLLRQVGVNPVIVHGGGPMINALLDK
LQIKSEFVNGKRVTDAATMEVVEMVLSGMVNKRIVQAINAQGGKGIGLSGKDANLITCEATDPALGFVGTPSEVNADMLK
NLFEKEFIPVIAPIGSGTAGETFNINGDTAAGAVAAALKADRLLLLTDVAGVKNAEGVVVTELKAADVEEMTAAGVIAGG
MIPKTETALAAVRGGVRACTIVDGRVPNAVLLELFTDHGAGSMIRS

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI145693208, Length=235, Percent_Identity=34.0425531914894, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789181, Length=281, Percent_Identity=27.4021352313167, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320913, Length=280, Percent_Identity=25, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGB_SILST (Q1GJY2)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612296.1
- ProteinModelPortal:   Q1GJY2
- SMR:   Q1GJY2
- STRING:   Q1GJY2
- GeneID:   4077124
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0301
- NMPDR:   fig|292414.1.peg.2516
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- PhylomeDB:   Q1GJY2
- ProtClustDB:   PRK00942
- BioCyc:   SSP292414:TM1040_0301-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 29744; Mature: 29744

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: BINDING 92-92 BINDING 184-184

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRDMNRDWIATAETLSSALPYLQRYDDAIVVIKLGGHAMGSDEGMESFARDVVLLRQV
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GVNPVIVHGGGPMINALLDKLQIKSEFVNGKRVTDAATMEVVEMVLSGMVNKRIVQAINA
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QGGKGIGLSGKDANLITCEATDPALGFVGTPSEVNADMLKNLFEKEFIPVIAPIGSGTAG
CCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCC
ETFNINGDTAAGAVAAALKADRLLLLTDVAGVKNAEGVVVTELKAADVEEMTAAGVIAGG
CEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHCCC
MIPKTETALAAVRGGVRACTIVDGRVPNAVLLELFTDHGAGSMIRS
CCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure
MKTRDMNRDWIATAETLSSALPYLQRYDDAIVVIKLGGHAMGSDEGMESFARDVVLLRQV
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
GVNPVIVHGGGPMINALLDKLQIKSEFVNGKRVTDAATMEVVEMVLSGMVNKRIVQAINA
CCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
QGGKGIGLSGKDANLITCEATDPALGFVGTPSEVNADMLKNLFEKEFIPVIAPIGSGTAG
CCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCC
ETFNINGDTAAGAVAAALKADRLLLLTDVAGVKNAEGVVVTELKAADVEEMTAAGVIAGG
CEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHCCC
MIPKTETALAAVRGGVRACTIVDGRVPNAVLLELFTDHGAGSMIRS
CCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA