Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 99080062

GI number: 99080062

Start: 236023

End: 237453

Strand: Direct

Name: luxQ [H]

Synonym: TM1040_0221

Alternate gene names: 99080062

Gene position: 236023-237453 (Clockwise)

Preceding gene: 99080061

Following gene: 99080065

Centisome position: 7.37

GC content: 61.15

Gene sequence:

>1431_bases
ATGTCTGATCCTGCGTATGATGCCATGACCCCAGAGGAGTTGCGCGCGGCTTTGATGCAAGAGCGCAGGTTGCGCGCAGA
ACTCGAAGAATCCATGGAGCGCAAGTCCCAATCGCTGCGCCGGGCGAACGCGTCCCTCGTGTCCTTGGCCCGACAGATCG
ACCGGATGGTCAAAGAGCGCACCGAAGACCTCGCCCGCGACCGGGCCGAGGCGGAGGCCGAAAGTGCCGCAAAGACCCAG
TTTCTGGCCACGATGAGCCATGAAATCCGCACCCCGCTCAACGGTGTTCTCGGGATGGCATCGGCACTTGCGGATACCGA
ACTGGCCGAGCGTCAATCGCAGATCCTTGGGGTTCTACGCGAAAGCGGGCAATTGCTCCTGAACATCGTTGATGACATTC
TCGATCTCTCCAAGATCGAAGAGGGCAAGCTCGAACTCGAACGTCTGCCGACAGATGTGGTAGCTTTGATCGAGACGGTT
TATCGCCAGTTCAAACCGCGTATCGAGGCCAAGGGGCTCAATTTCAGCTCGATCTATGGCGAGGGGTTGGCGCAGGGCCC
CGCCTGGGTCCACATCGATCCCACCCGATTCCAGCAAGTGCTGACCAACCTGTTGTCCAATGCGATAAAATTCACCGACA
CGGGTGCGATTGCGCTTTCGTCCAGCCTTGTCTTGCAGCACGACGGTGAGCTCATTTTATGCGTTGCCGTGCGCGATACC
GGCGTCGGGCTCACGGATGCGCAAGTGGAGCGCTTGTTCCAACCCTACATGCAGGCCGATGCGAGCGTGGCGCGCAGCCA
TGGCGGCACCGGTCTTGGCTTGGCCATCGCGCGCCAGATCTGCGAGCGCATGGGGGGCACCCTGACCTGCCGCAGCCATG
AGGGCGATGGCAGCGAATTCTGCGCGACCTTTCGCGCCGCTCCGGCAGAGCCCGTGGTCTCGTCCCATGACCCCCAGGAC
GAGAACGAACTGGAGGCGCTGAGGGCGCAACGCTGGAAGGTGCTGGTGGCCGAGGACAACCGAACCAACCGGATGGTTCT
CCACCATATCCTGCGCGGCTATGACCTGGATTTGTACTGGGTGGACAATGGCGAAGAGGCGGTAAAAACCTGGCGTCAAG
AACGGCCGGATCTGGTGCTGATGGATGTGAATATGCCGCAGCTCGACGGGGTGTCTGCGACCTCTGTAATCCGTCAAGAA
GAGGCTGATGCACAAGCCGCGCCGGTGCCGATCATTGCGGTGTCGGCCAATGCGCTGGTGCATCAGATCAAAAGCTACCT
CGCGAGCGGCATGACCGACCATGTCGCCAAACCGATCCGCAAGAAAAAGCTGTTGTCAGCCATGGCGCGCGCGTTGAAGT
CCCGCCCAACGCTGCCCCCCGTGCCAGAAGAACCAGCGGACAAAGGCGCAGCGCGGGTGCTCTCGCCCTAG

Upstream 100 bases:

>100_bases
GCATGGGCCGCTCCGACATCGCCGCAGATCTGGCACTGTTGTGCAGGCGGGCAGGGGGGGCGCCTCGCGCCGCATGACAT
CAACGTGAGACGCAGCTGCA

Downstream 100 bases:

>100_bases
CAGCTATGCCGCGCGCCGCCTCAGCAAATAAAAACCAGCAGGGAGGATCGCTCCGATGCTGGTTCCATGTGCGCCCCCTG
GGGCGGTGTCTCAATTGGGA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSDPAYDAMTPEELRAALMQERRLRAELEESMERKSQSLRRANASLVSLARQIDRMVKERTEDLARDRAEAEAESAAKTQ
FLATMSHEIRTPLNGVLGMASALADTELAERQSQILGVLRESGQLLLNIVDDILDLSKIEEGKLELERLPTDVVALIETV
YRQFKPRIEAKGLNFSSIYGEGLAQGPAWVHIDPTRFQQVLTNLLSNAIKFTDTGAIALSSSLVLQHDGELILCVAVRDT
GVGLTDAQVERLFQPYMQADASVARSHGGTGLGLAIARQICERMGGTLTCRSHEGDGSEFCATFRAAPAEPVVSSHDPQD
ENELEALRAQRWKVLVAEDNRTNRMVLHHILRGYDLDLYWVDNGEEAVKTWRQERPDLVLMDVNMPQLDGVSATSVIRQE
EADAQAAPVPIIAVSANALVHQIKSYLASGMTDHVAKPIRKKKLLSAMARALKSRPTLPPVPEEPADKGAARVLSP

Sequences:

>Translated_476_residues
MSDPAYDAMTPEELRAALMQERRLRAELEESMERKSQSLRRANASLVSLARQIDRMVKERTEDLARDRAEAEAESAAKTQ
FLATMSHEIRTPLNGVLGMASALADTELAERQSQILGVLRESGQLLLNIVDDILDLSKIEEGKLELERLPTDVVALIETV
YRQFKPRIEAKGLNFSSIYGEGLAQGPAWVHIDPTRFQQVLTNLLSNAIKFTDTGAIALSSSLVLQHDGELILCVAVRDT
GVGLTDAQVERLFQPYMQADASVARSHGGTGLGLAIARQICERMGGTLTCRSHEGDGSEFCATFRAAPAEPVVSSHDPQD
ENELEALRAQRWKVLVAEDNRTNRMVLHHILRGYDLDLYWVDNGEEAVKTWRQERPDLVLMDVNMPQLDGVSATSVIRQE
EADAQAAPVPIIAVSANALVHQIKSYLASGMTDHVAKPIRKKKLLSAMARALKSRPTLPPVPEEPADKGAARVLSP
>Mature_475_residues
SDPAYDAMTPEELRAALMQERRLRAELEESMERKSQSLRRANASLVSLARQIDRMVKERTEDLARDRAEAEAESAAKTQF
LATMSHEIRTPLNGVLGMASALADTELAERQSQILGVLRESGQLLLNIVDDILDLSKIEEGKLELERLPTDVVALIETVY
RQFKPRIEAKGLNFSSIYGEGLAQGPAWVHIDPTRFQQVLTNLLSNAIKFTDTGAIALSSSLVLQHDGELILCVAVRDTG
VGLTDAQVERLFQPYMQADASVARSHGGTGLGLAIARQICERMGGTLTCRSHEGDGSEFCATFRAAPAEPVVSSHDPQDE
NELEALRAQRWKVLVAEDNRTNRMVLHHILRGYDLDLYWVDNGEEAVKTWRQERPDLVLMDVNMPQLDGVSATSVIRQEE
ADAQAAPVPIIAVSANALVHQIKSYLASGMTDHVAKPIRKKKLLSAMARALKSRPTLPPVPEEPADKGAARVLSP

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=381, Percent_Identity=32.8083989501312, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI48994928, Length=376, Percent_Identity=33.7765957446808, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87081816, Length=414, Percent_Identity=33.5748792270531, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=40.7563025210084, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI145693157, Length=288, Percent_Identity=36.1111111111111, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=29.8245614035088, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=28.8461538461538, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=263, Percent_Identity=29.277566539924, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=27.1966527196653, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=28.8793103448276, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=26.271186440678, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=28.0701754385965, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=26.0089686098655, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=214, Percent_Identity=25.2336448598131, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=163, Percent_Identity=34.9693251533742, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322044, Length=73, Percent_Identity=41.0958904109589, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52404; Mature: 52273

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPAYDAMTPEELRAALMQERRLRAELEESMERKSQSLRRANASLVSLARQIDRMVKER
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEDLARDRAEAEAESAAKTQFLATMSHEIRTPLNGVLGMASALADTELAERQSQILGVLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESGQLLLNIVDDILDLSKIEEGKLELERLPTDVVALIETVYRQFKPRIEAKGLNFSSIYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHC
EGLAQGPAWVHIDPTRFQQVLTNLLSNAIKFTDTGAIALSSSLVLQHDGELILCVAVRDT
CHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCEEEEEEEECC
GVGLTDAQVERLFQPYMQADASVARSHGGTGLGLAIARQICERMGGTLTCRSHEGDGSEF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHH
CATFRAAPAEPVVSSHDPQDENELEALRAQRWKVLVAEDNRTNRMVLHHILRGYDLDLYW
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCEEEEE
VDNGEEAVKTWRQERPDLVLMDVNMPQLDGVSATSVIRQEEADAQAAPVPIIAVSANALV
ECCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECHHHHH
HQIKSYLASGMTDHVAKPIRKKKLLSAMARALKSRPTLPPVPEEPADKGAARVLSP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDPAYDAMTPEELRAALMQERRLRAELEESMERKSQSLRRANASLVSLARQIDRMVKER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEDLARDRAEAEAESAAKTQFLATMSHEIRTPLNGVLGMASALADTELAERQSQILGVLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESGQLLLNIVDDILDLSKIEEGKLELERLPTDVVALIETVYRQFKPRIEAKGLNFSSIYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHC
EGLAQGPAWVHIDPTRFQQVLTNLLSNAIKFTDTGAIALSSSLVLQHDGELILCVAVRDT
CHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCEEEEEEEECC
GVGLTDAQVERLFQPYMQADASVARSHGGTGLGLAIARQICERMGGTLTCRSHEGDGSEF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHH
CATFRAAPAEPVVSSHDPQDENELEALRAQRWKVLVAEDNRTNRMVLHHILRGYDLDLYW
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCEEEEE
VDNGEEAVKTWRQERPDLVLMDVNMPQLDGVSATSVIRQEEADAQAAPVPIIAVSANALV
ECCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECHHHHH
HQIKSYLASGMTDHVAKPIRKKKLLSAMARALKSRPTLPPVPEEPADKGAARVLSP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]