Click here to switch to the map view.

The map label for this gene is fabB [H]

Identifier: 99080022

GI number: 99080022

Start: 200236

End: 201465

Strand: Reverse

Name: fabB [H]

Synonym: TM1040_0181

Alternate gene names: 99080022

Gene position: 201465-200236 (Counterclockwise)

Preceding gene: 99080023

Following gene: 99080021

Centisome position: 6.29

GC content: 61.22

Gene sequence:

>1230_bases
ATGCGTCGCGTCGTCGTCACCGGCTTGGGGATTGTCTCCTCGATCGGGAACAATGCCGAAGAGGTCATCGCCTCCCTACG
GGCCGGAAAGTCCGGGATTGTCGCCAGCGAAGAGATGGCGGAGCATGGCTTTCGCAGCCAGATCGCAGGCACGCTGAAAA
TCGACCCTGCCGAGCACGTGGACAAGCGCACCCTGCGCTTCATGGGCCCCGGTGCGGCCTATGCCCATATCGCAATGGGC
CAGGCGATTGCAGATGCGGGCCTCTCCGAAGATCAGGTCGTCAACGAGCGCACCGGTCTGGTGGCAGGCTCTGGCGGGCC
ATCCACGTCCTCAATGCTGACCGCGCATCAGACCGTGCTGAAAACCGGCGCAACCAAGCGCATCGGGCCCTTCGCAGTGC
CAAAGTGCATGTCCTCTACGATCTCGGCCAACCTTGCGACTGCCTACAAGATCAAGGGCATCAACTACTCCATCACCTCG
GCCTGCTCCACATCGCTGCACTGCATCGGCAACGCAGCAGAGCAGATCATGATGGGCAAGCAGGACGTGATGTTTGCCGG
TGGTGGCGAGGAACTGGATTGGACCCTGTCCTGCCTCTTTGACGCCATGGGCGCGATGTCCTCCAAATACAACGAAACCC
CCGAAAAAGCCTCCCGCGCGTTCGATCAGGACCGCGATGGTTTTGTGATCTCGGGCGGTGGCGGCATCGTGGTGCTCGAG
GATCTCGAACACGCGTTGGCGCGGGGCGCCAAGATCTATGCAGAAGTCACCGGCTTTGCTGCGACTTCCGATGGGCACGA
CATGGTCGCACCGTCCGGCGAGGGCGGCGAGCGCGCGATGCGACTGGCCCTGCAAACCCTACCCGAGGGGCGCAAGGTGT
CTTATATCAACGCGCATGGCACCTCGACGCCGGTGGGCGATGTCGGCGAAGTCGAAGCCGCGCGCCGTGTCTTTGGCGCC
GGCAATGTGCCGCCAATTTCCTCGACCAAATCCATGACCGGCCATGCGCAGGGTGCGGCAGGCGCTCTGGAGGCAATCTT
CTGCCTCTTGATGCTCGACAATGATTTCATCACGCCGTCCATCAACGTCGAGACCCTCGCAGAGGGCATCGAAGAGGGCG
AAGTGGCCACACAATATGTTGAAAACGCGGGACTCGACAGTGTCATGACCAACAGCTTCGGCTTTGGCGGCACCAACGGC
TCCATGGTTCTGAGTAAGTACAAGGAATAA

Upstream 100 bases:

>100_bases
GCTCTGTCCGAGAGCTGATCCGCCTGTCGGATTGCCTCGGGCCCCCAGAGCCCTCCAATTGGGGTGCGCCCCCTTCACAC
CAGTTACAGGAGTACGCAAT

Downstream 100 bases:

>100_bases
CGACCGTGACTGGAGTATTGACCGGCAAACGGGGCCTGATCATGGGCGTTGCAAACGAACGCTCTATCGCTTGGGGGATC
GCCAAGGCGATGCATGAGGC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRRVVVTGLGIVSSIGNNAEEVIASLRAGKSGIVASEEMAEHGFRSQIAGTLKIDPAEHVDKRTLRFMGPGAAYAHIAMG
QAIADAGLSEDQVVNERTGLVAGSGGPSTSSMLTAHQTVLKTGATKRIGPFAVPKCMSSTISANLATAYKIKGINYSITS
ACSTSLHCIGNAAEQIMMGKQDVMFAGGGEELDWTLSCLFDAMGAMSSKYNETPEKASRAFDQDRDGFVISGGGGIVVLE
DLEHALARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLALQTLPEGRKVSYINAHGTSTPVGDVGEVEAARRVFGA
GNVPPISSTKSMTGHAQGAAGALEAIFCLLMLDNDFITPSINVETLAEGIEEGEVATQYVENAGLDSVMTNSFGFGGTNG
SMVLSKYKE

Sequences:

>Translated_409_residues
MRRVVVTGLGIVSSIGNNAEEVIASLRAGKSGIVASEEMAEHGFRSQIAGTLKIDPAEHVDKRTLRFMGPGAAYAHIAMG
QAIADAGLSEDQVVNERTGLVAGSGGPSTSSMLTAHQTVLKTGATKRIGPFAVPKCMSSTISANLATAYKIKGINYSITS
ACSTSLHCIGNAAEQIMMGKQDVMFAGGGEELDWTLSCLFDAMGAMSSKYNETPEKASRAFDQDRDGFVISGGGGIVVLE
DLEHALARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLALQTLPEGRKVSYINAHGTSTPVGDVGEVEAARRVFGA
GNVPPISSTKSMTGHAQGAAGALEAIFCLLMLDNDFITPSINVETLAEGIEEGEVATQYVENAGLDSVMTNSFGFGGTNG
SMVLSKYKE
>Mature_409_residues
MRRVVVTGLGIVSSIGNNAEEVIASLRAGKSGIVASEEMAEHGFRSQIAGTLKIDPAEHVDKRTLRFMGPGAAYAHIAMG
QAIADAGLSEDQVVNERTGLVAGSGGPSTSSMLTAHQTVLKTGATKRIGPFAVPKCMSSTISANLATAYKIKGINYSITS
ACSTSLHCIGNAAEQIMMGKQDVMFAGGGEELDWTLSCLFDAMGAMSSKYNETPEKASRAFDQDRDGFVISGGGGIVVLE
DLEHALARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLALQTLPEGRKVSYINAHGTSTPVGDVGEVEAARRVFGA
GNVPPISSTKSMTGHAQGAAGALEAIFCLLMLDNDFITPSINVETLAEGIEEGEVATQYVENAGLDSVMTNSFGFGGTNG
SMVLSKYKE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=431, Percent_Identity=34.1067285382831, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI41872631, Length=340, Percent_Identity=29.7058823529412, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI223972627, Length=174, Percent_Identity=36.7816091954023, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=56.3414634146341, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=38.6861313868613, Blast_Score=258, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=33.8862559241706, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=38.8461538461538, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=369, Percent_Identity=27.6422764227642, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=30.0724637681159, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320904, Length=451, Percent_Identity=29.9334811529933, Blast_Score=176, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=37.1158392434988, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=27.2189349112426, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=27.2189349112426, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24581345, Length=363, Percent_Identity=24.7933884297521, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42472; Mature: 42472

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGIVSSIGNNAEEVIASLRAGKSGIVASEEMAEHGFRSQIAGTLKIDPAEHV
CCEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCEECHHHHHCCHHHHCCEEEEECCHHHH
DKRTLRFMGPGAAYAHIAMGQAIADAGLSEDQVVNERTGLVAGSGGPSTSSMLTAHQTVL
HHHHHHEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCCCHHHHHHHHHHH
KTGATKRIGPFAVPKCMSSTISANLATAYKIKGINYSITSACSTSLHCIGNAAEQIMMGK
HCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEHHHHHCCHHHHHHHHHHHHHCCC
QDVMFAGGGEELDWTLSCLFDAMGAMSSKYNETPEKASRAFDQDRDGFVISGGGGIVVLE
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCEEEEH
DLEHALARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLALQTLPEGRKVSYINAHG
HHHHHHHCCCEEEEEEECEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
TSTPVGDVGEVEAARRVFGAGNVPPISSTKSMTGHAQGAAGALEAIFCLLMLDNDFITPS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
INVETLAEGIEEGEVATQYVENAGLDSVMTNSFGFGGTNGSMVLSKYKE
CCHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure
MRRVVVTGLGIVSSIGNNAEEVIASLRAGKSGIVASEEMAEHGFRSQIAGTLKIDPAEHV
CCEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCEECHHHHHCCHHHHCCEEEEECCHHHH
DKRTLRFMGPGAAYAHIAMGQAIADAGLSEDQVVNERTGLVAGSGGPSTSSMLTAHQTVL
HHHHHHEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCEEECCCCCCCHHHHHHHHHHH
KTGATKRIGPFAVPKCMSSTISANLATAYKIKGINYSITSACSTSLHCIGNAAEQIMMGK
HCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCEEHHHHHCCHHHHHHHHHHHHHCCC
QDVMFAGGGEELDWTLSCLFDAMGAMSSKYNETPEKASRAFDQDRDGFVISGGGGIVVLE
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCEEEEH
DLEHALARGAKIYAEVTGFAATSDGHDMVAPSGEGGERAMRLALQTLPEGRKVSYINAHG
HHHHHHHCCCEEEEEEECEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
TSTPVGDVGEVEAARRVFGAGNVPPISSTKSMTGHAQGAAGALEAIFCLLMLDNDFITPS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
INVETLAEGIEEGEVATQYVENAGLDSVMTNSFGFGGTNGSMVLSKYKE
CCHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]