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The map label for this gene is tpa [H]

Identifier: 99080000

GI number: 99080000

Start: 174832

End: 176232

Strand: Reverse

Name: tpa [H]

Synonym: TM1040_0159

Alternate gene names: 99080000

Gene position: 176232-174832 (Counterclockwise)

Preceding gene: 99080004

Following gene: 99079997

Centisome position: 5.51

GC content: 58.82

Gene sequence:

>1401_bases
ATGCACGGCACGTTCACCGACAATGACCTCAGCCATGTGATCGAGGCCGACAAGGCCCACGTCTGGCATCACCTGGTCCA
GCACAAGCCGTTTGAAACCTCCGATCCGCGGATTATCGTCGAGGGAAAAGGCATGCGCGTCTGGGACCAGAACGGCAAAG
AATGGCTCGACGCGGTGTCCGGTGCGGTCTGGACCGTCAACGTCGGCTATGGACGCGAAAGCATCTGCAAGGCCGTCTAC
GACCAGATGATGAAGATGTGCTATTTTGCGCAGGCGGCCGGGTCTGTTCCAGGCGCGCTCTATGCCGAAAAGCTCATTGA
GAAAATGCCGGGTATGTCCCGTGTCTACTACTGCAACTCCGGTTCCGAGGCCAACGAGAAGGCCTTTAAGATGGTGCGCC
AAATCGCACACAAGAAATACGGCGGCAAGAAAACCAAGATCCTTTACCGCGACCGCGATTATCATGGCTCCACGCTGGCG
GCGATGTCTGCGGGCGGTCAGGACGAGCGCAACGCGCAATACGGCCCCTTCGCCCCCGATTTCGTCCGCGTTCCGCATTG
CATGGAATACCGCAAGCATGAGCTTGGCCTTGAGCATCTCTCTGGCGAGGAATTCGGCATCGCGGCGGCCAACCTGATCG
AAGAAGTCATCCTGCGCGAAGGCCCAGAGACCGTCGGCGCACTCTGCCTTGAGCCCGTCACCGCAGGTGGTGGCGTCATC
GAAGCGCCAGAGGGCTACTGGCCGCGCGTGCAGGAGATCTGCAAGACCTATGATGTGCTCTTGCATATCGATGAGGTCGT
CTGCGGCATCGGGCGCACAGGCACCCATTGGTTTGGCTACCAGCACTACGGAATCAAGCCTGACTTCGTGACCATGGCCA
AAGGCGTTGCCTCCGGCTATGCAGCCATCGCCTGTATGGTCACAACCGAAGAGGTCTTTGAACTGTTCAAGGACGATACC
TCCGACAAGCTCAACTATTTCCGTGACATCTCGACCTTTGGTGGCTGCACCGCGGGTCCTGCGGCCGCGCTTGAAAACAT
GCGCATCATCGAGGACGAGGGCCTTCTGGAAAACTGCACCAAGATGGGCGAACGGATGATCTCGAACCTGCGCGTCCTAC
AGGAAAAACACGCTGTGATCGGCGATGTGCGGGGCAAGGGGCTGTTTCTTGGCGCCGAGCTGGTGACGGACCGCGACACC
AAGGAACCCGTGGAAGAAGCCTTGGCACAGAAGGTCGTCGCCGAATGTGGAAATCATGGGGTCATCATCGGTGTCACCAA
CCGCTCGGTGCCCGGACGCAACAACACATTGTGTTTCTCGCCCGCGCTCATCGCCACTGCGGATGACATCGACAAGATCA
CCGATGCGGTCGACAAGGCGTTGACCACGGTCTTTGGCTAA

Upstream 100 bases:

>100_bases
CCTATTCCACATCTGCAAAGTGTCATTTTCTGACGCCCGACACAGGGCGCATTCATCACGCCCCTGCTCTTCTTCGAATA
AGCCATGAAAGGAACATGTC

Downstream 100 bases:

>100_bases
CCTGACCAATAGGTCCCACGCCCATTGAAAAAGGCGGCTCCCACCTCGGGGCCGCCTTTTTACATCGTCTGACATGCGGC
ACTTAGATCCACTTGCGGCA

Product: aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MHGTFTDNDLSHVIEADKAHVWHHLVQHKPFETSDPRIIVEGKGMRVWDQNGKEWLDAVSGAVWTVNVGYGRESICKAVY
DQMMKMCYFAQAAGSVPGALYAEKLIEKMPGMSRVYYCNSGSEANEKAFKMVRQIAHKKYGGKKTKILYRDRDYHGSTLA
AMSAGGQDERNAQYGPFAPDFVRVPHCMEYRKHELGLEHLSGEEFGIAAANLIEEVILREGPETVGALCLEPVTAGGGVI
EAPEGYWPRVQEICKTYDVLLHIDEVVCGIGRTGTHWFGYQHYGIKPDFVTMAKGVASGYAAIACMVTTEEVFELFKDDT
SDKLNYFRDISTFGGCTAGPAAALENMRIIEDEGLLENCTKMGERMISNLRVLQEKHAVIGDVRGKGLFLGAELVTDRDT
KEPVEEALAQKVVAECGNHGVIIGVTNRSVPGRNNTLCFSPALIATADDIDKITDAVDKALTTVFG

Sequences:

>Translated_466_residues
MHGTFTDNDLSHVIEADKAHVWHHLVQHKPFETSDPRIIVEGKGMRVWDQNGKEWLDAVSGAVWTVNVGYGRESICKAVY
DQMMKMCYFAQAAGSVPGALYAEKLIEKMPGMSRVYYCNSGSEANEKAFKMVRQIAHKKYGGKKTKILYRDRDYHGSTLA
AMSAGGQDERNAQYGPFAPDFVRVPHCMEYRKHELGLEHLSGEEFGIAAANLIEEVILREGPETVGALCLEPVTAGGGVI
EAPEGYWPRVQEICKTYDVLLHIDEVVCGIGRTGTHWFGYQHYGIKPDFVTMAKGVASGYAAIACMVTTEEVFELFKDDT
SDKLNYFRDISTFGGCTAGPAAALENMRIIEDEGLLENCTKMGERMISNLRVLQEKHAVIGDVRGKGLFLGAELVTDRDT
KEPVEEALAQKVVAECGNHGVIIGVTNRSVPGRNNTLCFSPALIATADDIDKITDAVDKALTTVFG
>Mature_466_residues
MHGTFTDNDLSHVIEADKAHVWHHLVQHKPFETSDPRIIVEGKGMRVWDQNGKEWLDAVSGAVWTVNVGYGRESICKAVY
DQMMKMCYFAQAAGSVPGALYAEKLIEKMPGMSRVYYCNSGSEANEKAFKMVRQIAHKKYGGKKTKILYRDRDYHGSTLA
AMSAGGQDERNAQYGPFAPDFVRVPHCMEYRKHELGLEHLSGEEFGIAAANLIEEVILREGPETVGALCLEPVTAGGGVI
EAPEGYWPRVQEICKTYDVLLHIDEVVCGIGRTGTHWFGYQHYGIKPDFVTMAKGVASGYAAIACMVTTEEVFELFKDDT
SDKLNYFRDISTFGGCTAGPAAALENMRIIEDEGLLENCTKMGERMISNLRVLQEKHAVIGDVRGKGLFLGAELVTDRDT
KEPVEEALAQKVVAECGNHGVIIGVTNRSVPGRNNTLCFSPALIATADDIDKITDAVDKALTTVFG

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=446, Percent_Identity=29.8206278026906, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI226442705, Length=446, Percent_Identity=30.0448430493274, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI24119277, Length=444, Percent_Identity=28.3783783783784, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI13994255, Length=444, Percent_Identity=27.027027027027, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442709, Length=374, Percent_Identity=30.7486631016043, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4557809, Length=465, Percent_Identity=24.3010752688172, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI284507298, Length=347, Percent_Identity=24.4956772334294, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788044, Length=426, Percent_Identity=27.6995305164319, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789759, Length=429, Percent_Identity=28.9044289044289, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI145693181, Length=419, Percent_Identity=27.2076372315036, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789016, Length=381, Percent_Identity=28.0839895013123, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787560, Length=391, Percent_Identity=27.3657289002558, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1786991, Length=461, Percent_Identity=24.295010845987, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=445, Percent_Identity=29.2134831460674, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32564660, Length=455, Percent_Identity=28.5714285714286, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144271, Length=438, Percent_Identity=26.027397260274, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=316, Percent_Identity=25.3164556962025, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71981843, Length=154, Percent_Identity=29.8701298701299, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=27.3563218390805, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6324432, Length=442, Percent_Identity=26.2443438914027, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324386, Length=491, Percent_Identity=24.6435845213849, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=387, Percent_Identity=24.5478036175711, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161085790, Length=465, Percent_Identity=27.741935483871, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574759, Length=466, Percent_Identity=27.8969957081545, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356575, Length=441, Percent_Identity=28.1179138321995, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21357415, Length=448, Percent_Identity=25.8928571428571, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 51272; Mature: 51272

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGTFTDNDLSHVIEADKAHVWHHLVQHKPFETSDPRIIVEGKGMRVWDQNGKEWLDAVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCHHHHHHHC
GAVWTVNVGYGRESICKAVYDQMMKMCYFAQAAGSVPGALYAEKLIEKMPGMSRVYYCNS
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECC
GSEANEKAFKMVRQIAHKKYGGKKTKILYRDRDYHGSTLAAMSAGGQDERNAQYGPFAPD
CCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCHH
FVRVPHCMEYRKHELGLEHLSGEEFGIAAANLIEEVILREGPETVGALCLEPVTAGGGVI
HHCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEE
EAPEGYWPRVQEICKTYDVLLHIDEVVCGIGRTGTHWFGYQHYGIKPDFVTMAKGVASGY
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCH
AAIACMVTTEEVFELFKDDTSDKLNYFRDISTFGGCTAGPAAALENMRIIEDEGLLENCT
HHEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCEEECCCCHHHHHH
KMGERMISNLRVLQEKHAVIGDVRGKGLFLGAELVTDRDTKEPVEEALAQKVVAECGNHG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
VIIGVTNRSVPGRNNTLCFSPALIATADDIDKITDAVDKALTTVFG
EEEEECCCCCCCCCCEEEECCHHEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHGTFTDNDLSHVIEADKAHVWHHLVQHKPFETSDPRIIVEGKGMRVWDQNGKEWLDAVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCHHHHHHHC
GAVWTVNVGYGRESICKAVYDQMMKMCYFAQAAGSVPGALYAEKLIEKMPGMSRVYYCNS
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECC
GSEANEKAFKMVRQIAHKKYGGKKTKILYRDRDYHGSTLAAMSAGGQDERNAQYGPFAPD
CCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCHH
FVRVPHCMEYRKHELGLEHLSGEEFGIAAANLIEEVILREGPETVGALCLEPVTAGGGVI
HHCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEE
EAPEGYWPRVQEICKTYDVLLHIDEVVCGIGRTGTHWFGYQHYGIKPDFVTMAKGVASGY
ECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCH
AAIACMVTTEEVFELFKDDTSDKLNYFRDISTFGGCTAGPAAALENMRIIEDEGLLENCT
HHEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCEEECCCCHHHHHH
KMGERMISNLRVLQEKHAVIGDVRGKGLFLGAELVTDRDTKEPVEEALAQKVVAECGNHG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
VIIGVTNRSVPGRNNTLCFSPALIATADDIDKITDAVDKALTTVFG
EEEEECCCCCCCCCCEEEECCHHEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]