Click here to switch to the map view.

The map label for this gene is xsc [H]

Identifier: 99079996

GI number: 99079996

Start: 169615

End: 171393

Strand: Reverse

Name: xsc [H]

Synonym: TM1040_0155

Alternate gene names: 99079996

Gene position: 171393-169615 (Counterclockwise)

Preceding gene: 99079997

Following gene: 99079995

Centisome position: 5.35

GC content: 60.82

Gene sequence:

>1779_bases
ATGCGCATGACCACCGAAGAAGCCTTTGTAAAAACACTGCAAATGCATGGTATCGAGCATGCGTTTGGCATTATCGGTTC
CGCGATGATGCCGATTTCAGATCTGTTTCCCAAGGCTGGGATCACGTTCTGGGACTGCGCGCATGAGGGCTCCGCCGGGA
TGATGGCCGATGGCTACACGCGGGTGACGGGCAACATGTCGATGATGATTGCGCAGAACGGCCCGGGCATCACCAACTTC
GTCACCGCCGTAAAAACCGCCTATTGGAACCACACGCCACTGCTGCTGGTGACGCCACAGGCTGCCAACAAGACCATCGG
CCAAGGGGGCTTTCAGGAGGTCGAACAGATGAAACTGTTCGAGGATATGGTGGCCTATCAAGAAGAGGTTCGCGACCCGA
GCCGCGTTGCGGAAGTTCTGAATCGCGTGATCTGCAACGCGAAACGCGCCTCGGCCCCGGCGCAGATCAACATTCCTCGC
GACATGTGGACTCAGGTCATCGATATCGCCCTCCCCGAAATCCTCACGTTCGAACGTCCTGCAGGAGGGGCGCAGGCCGT
CTCAGAAGCCGCCTCGCTCCTCTCTGAGGCCCAAAATCCGGTGATCCTCAATGGCGCAGGCGTGGTGCTCTCTGGCGGGG
GTATCGCCGCCTCCATGGCGCTGGCGGAGCGGCTCGATGCGCCGGTATGCGTTGGCTATCAGCACAATGACGCCTTTCCC
GGCACGCATCCTCTTTTTGTGGGTCCCTTGGGGTACAATGGCTCTAAAGCGGCGATGGAGCTGATCCGCGATGCCGATGT
CGTGCTTTGCCTCGGCACCCGACTCAACCCTTTTTCCACTCTGCCCGGCTATGGGATCGACTATTGGCCAACGGAAGCCG
ATATCATTCAGGTGGACATCAACCCAGATCGGATCGGGCTGACGAAACCGGTGCGTGTGGGGATTGTGGGGGACGCGGCC
AAAGTGGCCGATGGCATTCTGCAACAGCTCTCAGAGGACGCCGGAGATGCCGGGCGCTCCGCACGCAAGGCCCATATCGC
AGCAACAAAATCCCGCTGGGCGCAGCAGCTTGCCGCGATGGACCATGAAGACGACGACCCCGGCACCACCTGGAACGCCC
GCGCGCGGTCCGCAAAACCCGACTGGATGAGCCCACGCATGGCCTGGCGCGCGATACAGTCCGCACTCCCCTCAGACGCC
ATCATTTCGTCCGACATTGGTAACAACTGCGCCATCGGCAACGCCTATCCCACCTTCGAAGCAGGCCGCAAATATCTTGC
CCCGGGGCTGTTTGGCCCATGCGGGTATGGTTTGCCAGCGATCATGGGCGCCAAGATCGGCTGCCCCGAGACCCCGGTCG
TGGGCTTTGCCGGAGACGGTGCGTTTGGCATCTCGGTAAACGAGCTGACCGCTATTGGACGCGCAGAGTGGCCCGCAATT
ACGCAGGTGGTGTTTCGCAACTACCAATGGGGTGCCGAAAAACGCAACTCGACGCTCTGGTTTGACGACAATTTCGTGGG
CACAGAACTCGACACCAAGGTCTCTTATGCGGGGATTGCACAAGCCTGCGGCCTGAAAGGCGTTGTCGCGCGCACCATGG
AAGAGCTGACCGCGACGTTGCGCCACGCGATCGAGGATCAGGGCCGAGGCATCACCACGCTGATCGAAGCCCTGATCAAT
CAGGAGCTGGGAGAGCCCTTTCGCCGCGACGCCATGAAAAAGCCGGTGGCGATTGCCGGGATCTCGGCCGCAGACATGCG
TCCACAGGCGCGCGCCTGA

Upstream 100 bases:

>100_bases
CATACAACTGGCCCTAACCCCTTCGCGCAAGCCTGCATAAACCAAGGCATGGCGCGCCGCGAATGCGCGTCTCGCCACGC
CGCAATCGGGAGAGCCAACC

Downstream 100 bases:

>100_bases
TGGGGCCGGAGATGCTGGTGGATTTGCCCTTTGCGCTCACGGCGATGCAGGGGCTGTTTCTGGCAGCTGCCCTGTTTTTC
GCGGCCGTCATTCGCGGCTA

Product: sulfoacetaldehyde acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MRMTTEEAFVKTLQMHGIEHAFGIIGSAMMPISDLFPKAGITFWDCAHEGSAGMMADGYTRVTGNMSMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPSRVAEVLNRVICNAKRASAPAQINIPR
DMWTQVIDIALPEILTFERPAGGAQAVSEAASLLSEAQNPVILNGAGVVLSGGGIAASMALAERLDAPVCVGYQHNDAFP
GTHPLFVGPLGYNGSKAAMELIRDADVVLCLGTRLNPFSTLPGYGIDYWPTEADIIQVDINPDRIGLTKPVRVGIVGDAA
KVADGILQQLSEDAGDAGRSARKAHIAATKSRWAQQLAAMDHEDDDPGTTWNARARSAKPDWMSPRMAWRAIQSALPSDA
IISSDIGNNCAIGNAYPTFEAGRKYLAPGLFGPCGYGLPAIMGAKIGCPETPVVGFAGDGAFGISVNELTAIGRAEWPAI
TQVVFRNYQWGAEKRNSTLWFDDNFVGTELDTKVSYAGIAQACGLKGVVARTMEELTATLRHAIEDQGRGITTLIEALIN
QELGEPFRRDAMKKPVAIAGISAADMRPQARA

Sequences:

>Translated_592_residues
MRMTTEEAFVKTLQMHGIEHAFGIIGSAMMPISDLFPKAGITFWDCAHEGSAGMMADGYTRVTGNMSMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPSRVAEVLNRVICNAKRASAPAQINIPR
DMWTQVIDIALPEILTFERPAGGAQAVSEAASLLSEAQNPVILNGAGVVLSGGGIAASMALAERLDAPVCVGYQHNDAFP
GTHPLFVGPLGYNGSKAAMELIRDADVVLCLGTRLNPFSTLPGYGIDYWPTEADIIQVDINPDRIGLTKPVRVGIVGDAA
KVADGILQQLSEDAGDAGRSARKAHIAATKSRWAQQLAAMDHEDDDPGTTWNARARSAKPDWMSPRMAWRAIQSALPSDA
IISSDIGNNCAIGNAYPTFEAGRKYLAPGLFGPCGYGLPAIMGAKIGCPETPVVGFAGDGAFGISVNELTAIGRAEWPAI
TQVVFRNYQWGAEKRNSTLWFDDNFVGTELDTKVSYAGIAQACGLKGVVARTMEELTATLRHAIEDQGRGITTLIEALIN
QELGEPFRRDAMKKPVAIAGISAADMRPQARA
>Mature_592_residues
MRMTTEEAFVKTLQMHGIEHAFGIIGSAMMPISDLFPKAGITFWDCAHEGSAGMMADGYTRVTGNMSMMIAQNGPGITNF
VTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLFEDMVAYQEEVRDPSRVAEVLNRVICNAKRASAPAQINIPR
DMWTQVIDIALPEILTFERPAGGAQAVSEAASLLSEAQNPVILNGAGVVLSGGGIAASMALAERLDAPVCVGYQHNDAFP
GTHPLFVGPLGYNGSKAAMELIRDADVVLCLGTRLNPFSTLPGYGIDYWPTEADIIQVDINPDRIGLTKPVRVGIVGDAA
KVADGILQQLSEDAGDAGRSARKAHIAATKSRWAQQLAAMDHEDDDPGTTWNARARSAKPDWMSPRMAWRAIQSALPSDA
IISSDIGNNCAIGNAYPTFEAGRKYLAPGLFGPCGYGLPAIMGAKIGCPETPVVGFAGDGAFGISVNELTAIGRAEWPAI
TQVVFRNYQWGAEKRNSTLWFDDNFVGTELDTKVSYAGIAQACGLKGVVARTMEELTATLRHAIEDQGRGITTLIEALIN
QELGEPFRRDAMKKPVAIAGISAADMRPQARA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=595, Percent_Identity=22.8571428571429, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI93004078, Length=577, Percent_Identity=25.3032928942808, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI87081685, Length=552, Percent_Identity=27.1739130434783, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1790104, Length=566, Percent_Identity=26.1484098939929, Blast_Score=168, Evalue=8e-43,
Organism=Escherichia coli, GI1787096, Length=578, Percent_Identity=24.2214532871972, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786717, Length=560, Percent_Identity=25.1785714285714, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788716, Length=498, Percent_Identity=26.1044176706827, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17542570, Length=610, Percent_Identity=25.2459016393443, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17531299, Length=594, Percent_Identity=22.7272727272727, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17531301, Length=594, Percent_Identity=22.7272727272727, Blast_Score=105, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323755, Length=591, Percent_Identity=23.1810490693739, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320816, Length=579, Percent_Identity=22.6252158894646, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922626, Length=551, Percent_Identity=23.956442831216, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017820
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.3.3.15 [H]

Molecular weight: Translated: 63349; Mature: 63349

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMTTEEAFVKTLQMHGIEHAFGIIGSAMMPISDLFPKAGITFWDCAHEGSAGMMADGYT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCEECCEE
RVTGNMSMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLF
EEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
EDMVAYQEEVRDPSRVAEVLNRVICNAKRASAPAQINIPRDMWTQVIDIALPEILTFERP
HHHHHHHHHCCCHHHHHHHHHHHHHCCHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCC
AGGAQAVSEAASLLSEAQNPVILNGAGVVLSGGGIAASMALAERLDAPVCVGYQHNDAFP
CCHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCC
GTHPLFVGPLGYNGSKAAMELIRDADVVLCLGTRLNPFSTLPGYGIDYWPTEADIIQVDI
CCCCEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEC
NPDRIGLTKPVRVGIVGDAAKVADGILQQLSEDAGDAGRSARKAHIAATKSRWAQQLAAM
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
DHEDDDPGTTWNARARSAKPDWMSPRMAWRAIQSALPSDAIISSDIGNNCAIGNAYPTFE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCHH
AGRKYLAPGLFGPCGYGLPAIMGAKIGCPETPVVGFAGDGAFGISVNELTAIGRAEWPAI
HCHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEECCCCEEECCHHHHHHCCCCCCHHH
TQVVFRNYQWGAEKRNSTLWFDDNFVGTELDTKVSYAGIAQACGLKGVVARTMEELTATL
HHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
RHAIEDQGRGITTLIEALINQELGEPFRRDAMKKPVAIAGISAADMRPQARA
HHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCEEEECCCHHCCCCCCCC
>Mature Secondary Structure
MRMTTEEAFVKTLQMHGIEHAFGIIGSAMMPISDLFPKAGITFWDCAHEGSAGMMADGYT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHCCCCCCEEEECCCCCCCCCEECCEE
RVTGNMSMMIAQNGPGITNFVTAVKTAYWNHTPLLLVTPQAANKTIGQGGFQEVEQMKLF
EEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
EDMVAYQEEVRDPSRVAEVLNRVICNAKRASAPAQINIPRDMWTQVIDIALPEILTFERP
HHHHHHHHHCCCHHHHHHHHHHHHHCCHHCCCCCEEECCHHHHHHHHHHHHHHHHCCCCC
AGGAQAVSEAASLLSEAQNPVILNGAGVVLSGGGIAASMALAERLDAPVCVGYQHNDAFP
CCHHHHHHHHHHHHHHCCCCEEEECCCEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCC
GTHPLFVGPLGYNGSKAAMELIRDADVVLCLGTRLNPFSTLPGYGIDYWPTEADIIQVDI
CCCCEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEC
NPDRIGLTKPVRVGIVGDAAKVADGILQQLSEDAGDAGRSARKAHIAATKSRWAQQLAAM
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
DHEDDDPGTTWNARARSAKPDWMSPRMAWRAIQSALPSDAIISSDIGNNCAIGNAYPTFE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCHH
AGRKYLAPGLFGPCGYGLPAIMGAKIGCPETPVVGFAGDGAFGISVNELTAIGRAEWPAI
HCHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEECCCCEEECCHHHHHHCCCCCCHHH
TQVVFRNYQWGAEKRNSTLWFDDNFVGTELDTKVSYAGIAQACGLKGVVARTMEELTATL
HHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
RHAIEDQGRGITTLIEALINQELGEPFRRDAMKKPVAIAGISAADMRPQARA
HHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCEEEECCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]