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The map label for this gene is zraS [H]

Identifier: 99079953

GI number: 99079953

Start: 117301

End: 119205

Strand: Reverse

Name: zraS [H]

Synonym: TM1040_0112

Alternate gene names: 99079953

Gene position: 119205-117301 (Counterclockwise)

Preceding gene: 99079957

Following gene: 99079952

Centisome position: 3.72

GC content: 62.62

Gene sequence:

>1905_bases
ATGAAACAGAACACGGCACAACGCATGGCGATGATCGACGCAGGCCTGAACCTCATTGCGCAGGCCATGTCGATCTACGA
CCGCAACCTGCGCCTTGCGGCCTGCAACCATCGCTTTCAGGAAATGTTTTCACTGCCGCCCGAATTGGTGCAAGAGGGCG
CGACGTTCGAAGACACCATCCGCTTTATCGCGGTACAGGGCGACTATGGCCCCATTGATGACATCGATTCGTTTGTGCAG
CTGCGGGTGGAACAGGCCCGCGCCTTTGTGCCCCATTACGTCGAGCGCCAGCGTGCCAATGGCCATGTGATTTCGATCGA
GGGCGCGCCTCTTCCGGAGGGGGGCTGGGTCACGGTCTACACCGACATCACCCGCACCAAGCGGGTTGAAGAATTGCTCC
GCGCCCGCTCCGAGGAGCTCTCGGATCAGGTGATGAGCTACACAGAAGAGCTCTCGGCCACCAACCGAAAGCTTGCAGCC
ACGATCACCACACTTGAAGAGACCCAGCGCCAGCTGACGCAGACCGAGGCCCGCACCCGGCTCACGACCGAAATGATGCC
CGCCCATATCGCGCATGTGGATGCGGACGGGCATTATACCTTTACCAACGGACGTTTGAGCAAAGTGTTTCCCGGCCGCC
CCTCCGACATTCTCGGCCAGCATATTGCCGAGGCGCTCGGGTCCGCCGCCTATGCCCGCATCGCACCGCACCTCTCGGCG
GCCTACCAGGGTGAAAGCCCGGTGTTTGAGTTCACCGAGGATCAGGACAGCCGCCGCCTGCGCGTGGCGTTTACGCCCGA
CAACGAAGGCGGGGTGTTCATCCTGTCGATGGATGTGACCGAGGAAACCCAGACCCGCGTGGCCCTGCAACAGGCCCGCA
AGCGCGAGATCGCCGCGCAGATGACCAGCGGGCTTGCGCATGATTTCTCCAACCTTCTGACCATCATCCTCGGAATGCAG
ACACGCCTTGATCGGATGACCCTGCCCGAAGGCGCGGGCGAGCTCGTGGAGGCCACCCTGTCAGCCGCGCGGCGCGGCGG
GCGGCTCTTGGATCGGATGGCTGAAATGACCAGTCACCGTGGCCTGCGCCCGCAAGCCACCGACCTGCACGCGCTCTTGG
ACGAGATGAAGATCCTCGCCACGCCGTCACTACCACAGGGCATCGGTCTCAGCGTGCTGGACAACACAAGCGAGGGGCCG
GTCCTTTTGGATCCGGGGCGGCTGCAGGACGCGCTTTTGAACCTGATTTTGAATGCGCGCGACGCCTGCGGCACCAGCGG
CCAGATCACGGTTGCCGCGCATCTGGTCGGGCAGACCTGGATCGAATTCTCCGTAAGCGACACAGGCCCCGGCTTTTCAG
TGCAAGCGCTTGAGAATGCGCTCAACCCGTTTTTCACCACCAAGGGGCAAGAGGGCTCGGGGCTGGGGTTGTCGATGGTC
TATGACATGGTGAAATCCGCCGGGGGGGACATCCGCATCAGCAACACCGTCTCCGGCGCGATGGTGACGCTGCGCCTGCC
CTACCGCCCAGCGCCGATGGCGGCCGGCGGCATTGCCCTTCTGGTCGAAGACAGCGACACGCTTCGGGCGACCTATCGTC
AGGTGCTGATGGATCTTGGATACTCCGTCATCGAGGCCACCAGCGTTGATGAGGCCGTTGCGCTTTTGGCGGATGTCGAA
GGGATTGCACTGATCCTGTCGGACATCAAACTGGAAGGCGATGCCACCGGCGTCGATCTCTGCACCCGGCTGGGGCCGGA
TGCGCCACCCGTGGTACTGATGACCTCGTTGCCGCATACCGATCCGCTCTATCGCGCGGCCCTCACTCTGGCGCCACTCT
TGCCAAAACCCTTTGAAAGCGCGCATCTGATGGCGCTCCTGCAACAAAAGGCCGACCATGCCTGA

Upstream 100 bases:

>100_bases
TGATCGATCTGCAATTCCTGTCGGACCACCCTCAGGGGCGCAATCACAAGCCACTTTGCCAATGCGCCACAAGCTGTTAG
CCAAGAGGCGGGGAGCACGT

Downstream 100 bases:

>100_bases
TGCCAATGCCTCTCCGCTTGTCACCATTCTCGATGACGAGCCCGAAATCCGCCAGCTGCTGACCGAGACGCTGGAGGATG
CCGGGTATCGCACCCAGAGC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MKQNTAQRMAMIDAGLNLIAQAMSIYDRNLRLAACNHRFQEMFSLPPELVQEGATFEDTIRFIAVQGDYGPIDDIDSFVQ
LRVEQARAFVPHYVERQRANGHVISIEGAPLPEGGWVTVYTDITRTKRVEELLRARSEELSDQVMSYTEELSATNRKLAA
TITTLEETQRQLTQTEARTRLTTEMMPAHIAHVDADGHYTFTNGRLSKVFPGRPSDILGQHIAEALGSAAYARIAPHLSA
AYQGESPVFEFTEDQDSRRLRVAFTPDNEGGVFILSMDVTEETQTRVALQQARKREIAAQMTSGLAHDFSNLLTIILGMQ
TRLDRMTLPEGAGELVEATLSAARRGGRLLDRMAEMTSHRGLRPQATDLHALLDEMKILATPSLPQGIGLSVLDNTSEGP
VLLDPGRLQDALLNLILNARDACGTSGQITVAAHLVGQTWIEFSVSDTGPGFSVQALENALNPFFTTKGQEGSGLGLSMV
YDMVKSAGGDIRISNTVSGAMVTLRLPYRPAPMAAGGIALLVEDSDTLRATYRQVLMDLGYSVIEATSVDEAVALLADVE
GIALILSDIKLEGDATGVDLCTRLGPDAPPVVLMTSLPHTDPLYRAALTLAPLLPKPFESAHLMALLQQKADHA

Sequences:

>Translated_634_residues
MKQNTAQRMAMIDAGLNLIAQAMSIYDRNLRLAACNHRFQEMFSLPPELVQEGATFEDTIRFIAVQGDYGPIDDIDSFVQ
LRVEQARAFVPHYVERQRANGHVISIEGAPLPEGGWVTVYTDITRTKRVEELLRARSEELSDQVMSYTEELSATNRKLAA
TITTLEETQRQLTQTEARTRLTTEMMPAHIAHVDADGHYTFTNGRLSKVFPGRPSDILGQHIAEALGSAAYARIAPHLSA
AYQGESPVFEFTEDQDSRRLRVAFTPDNEGGVFILSMDVTEETQTRVALQQARKREIAAQMTSGLAHDFSNLLTIILGMQ
TRLDRMTLPEGAGELVEATLSAARRGGRLLDRMAEMTSHRGLRPQATDLHALLDEMKILATPSLPQGIGLSVLDNTSEGP
VLLDPGRLQDALLNLILNARDACGTSGQITVAAHLVGQTWIEFSVSDTGPGFSVQALENALNPFFTTKGQEGSGLGLSMV
YDMVKSAGGDIRISNTVSGAMVTLRLPYRPAPMAAGGIALLVEDSDTLRATYRQVLMDLGYSVIEATSVDEAVALLADVE
GIALILSDIKLEGDATGVDLCTRLGPDAPPVVLMTSLPHTDPLYRAALTLAPLLPKPFESAHLMALLQQKADHA
>Mature_634_residues
MKQNTAQRMAMIDAGLNLIAQAMSIYDRNLRLAACNHRFQEMFSLPPELVQEGATFEDTIRFIAVQGDYGPIDDIDSFVQ
LRVEQARAFVPHYVERQRANGHVISIEGAPLPEGGWVTVYTDITRTKRVEELLRARSEELSDQVMSYTEELSATNRKLAA
TITTLEETQRQLTQTEARTRLTTEMMPAHIAHVDADGHYTFTNGRLSKVFPGRPSDILGQHIAEALGSAAYARIAPHLSA
AYQGESPVFEFTEDQDSRRLRVAFTPDNEGGVFILSMDVTEETQTRVALQQARKREIAAQMTSGLAHDFSNLLTIILGMQ
TRLDRMTLPEGAGELVEATLSAARRGGRLLDRMAEMTSHRGLRPQATDLHALLDEMKILATPSLPQGIGLSVLDNTSEGP
VLLDPGRLQDALLNLILNARDACGTSGQITVAAHLVGQTWIEFSVSDTGPGFSVQALENALNPFFTTKGQEGSGLGLSMV
YDMVKSAGGDIRISNTVSGAMVTLRLPYRPAPMAAGGIALLVEDSDTLRATYRQVLMDLGYSVIEATSVDEAVALLADVE
GIALILSDIKLEGDATGVDLCTRLGPDAPPVVLMTSLPHTDPLYRAALTLAPLLPKPFESAHLMALLQQKADHA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=32.7272727272727, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=27.9835390946502, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI48994928, Length=532, Percent_Identity=25.187969924812, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=26.6949152542373, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68953; Mature: 68953

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQNTAQRMAMIDAGLNLIAQAMSIYDRNLRLAACNHRFQEMFSLPPELVQEGATFEDTI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCHHHHHCCCCHHHEE
RFIAVQGDYGPIDDIDSFVQLRVEQARAFVPHYVERQRANGHVISIEGAPLPEGGWVTVY
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEE
TDITRTKRVEELLRARSEELSDQVMSYTEELSATNRKLAATITTLEETQRQLTQTEARTR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LTTEMMPAHIAHVDADGHYTFTNGRLSKVFPGRPSDILGQHIAEALGSAAYARIAPHLSA
HHHHHCCHHHEEEECCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYQGESPVFEFTEDQDSRRLRVAFTPDNEGGVFILSMDVTEETQTRVALQQARKREIAAQ
HCCCCCCCEECCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
MTSGLAHDFSNLLTIILGMQTRLDRMTLPEGAGELVEATLSAARRGGRLLDRMAEMTSHR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
GLRPQATDLHALLDEMKILATPSLPQGIGLSVLDNTSEGPVLLDPGRLQDALLNLILNAR
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCHHHHHHHHHHHHHCH
DACGTSGQITVAAHLVGQTWIEFSVSDTGPGFSVQALENALNPFFTTKGQEGSGLGLSMV
HCCCCCCCEEEEEEECCCCEEEEEECCCCCCEEHHHHHHHCCCCEECCCCCCCCCHHHHH
YDMVKSAGGDIRISNTVSGAMVTLRLPYRPAPMAAGGIALLVEDSDTLRATYRQVLMDLG
HHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCC
YSVIEATSVDEAVALLADVEGIALILSDIKLEGDATGVDLCTRLGPDAPPVVLMTSLPHT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCCEEEEECCCCC
DPLYRAALTLAPLLPKPFESAHLMALLQQKADHA
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQNTAQRMAMIDAGLNLIAQAMSIYDRNLRLAACNHRFQEMFSLPPELVQEGATFEDTI
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCHHHHHCCCCHHHEE
RFIAVQGDYGPIDDIDSFVQLRVEQARAFVPHYVERQRANGHVISIEGAPLPEGGWVTVY
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEE
TDITRTKRVEELLRARSEELSDQVMSYTEELSATNRKLAATITTLEETQRQLTQTEARTR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LTTEMMPAHIAHVDADGHYTFTNGRLSKVFPGRPSDILGQHIAEALGSAAYARIAPHLSA
HHHHHCCHHHEEEECCCCEEEECCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AYQGESPVFEFTEDQDSRRLRVAFTPDNEGGVFILSMDVTEETQTRVALQQARKREIAAQ
HCCCCCCCEECCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
MTSGLAHDFSNLLTIILGMQTRLDRMTLPEGAGELVEATLSAARRGGRLLDRMAEMTSHR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
GLRPQATDLHALLDEMKILATPSLPQGIGLSVLDNTSEGPVLLDPGRLQDALLNLILNAR
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCHHHHHHHHHHHHHCH
DACGTSGQITVAAHLVGQTWIEFSVSDTGPGFSVQALENALNPFFTTKGQEGSGLGLSMV
HCCCCCCCEEEEEEECCCCEEEEEECCCCCCEEHHHHHHHCCCCEECCCCCCCCCHHHHH
YDMVKSAGGDIRISNTVSGAMVTLRLPYRPAPMAAGGIALLVEDSDTLRATYRQVLMDLG
HHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCC
YSVIEATSVDEAVALLADVEGIALILSDIKLEGDATGVDLCTRLGPDAPPVVLMTSLPHT
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCCCCEEEEECCCCC
DPLYRAALTLAPLLPKPFESAHLMALLQQKADHA
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]