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The map label for this gene is lktA [H]

Identifier: 99079923

GI number: 99079923

Start: 85539

End: 86606

Strand: Reverse

Name: lktA [H]

Synonym: TM1040_0082

Alternate gene names: 99079923

Gene position: 86606-85539 (Counterclockwise)

Preceding gene: 99079924

Following gene: 99079922

Centisome position: 2.71

GC content: 62.92

Gene sequence:

>1068_bases
ATGTTGTGGTTGGCCAGTATCCTCGGAATGGTCGCAGTTGGCAGTGCGATCATGATTGATTTTGAGTCCGATGACGCGGA
TTCGGACGAAACAAATCCCGATGCCGAAGCGGATGGCACCGGCAGCACAATCGTCTCGCCTGACGAATTCCTCACGGGCG
TCGACCCTGCTGGCAACGATGCCTCCGACACCACAGAGACAGACGAGAGCCCTCAGGTCGCTGACGGTGACGACACTGAT
GAGCGCAATATCATCCTTGGTACGGAGGATCTCGATCAGCTCTCTGGCGGCGCGACCGATGATGAAATCTCGGGGCTGGG
GGGCGATGATCAGATCAACGGCTATGACGGCAATGACTACCTCAGCGGTGGCGCGGGTGCGGATGACCTTTATGGCGCGG
CCGGAGAAGATACACTCCACGGCGACGCGGGCGACGATCACCTCGACGGAGGAGAGGGACAGGATTCTCTTTCGGGGGGC
GACGGCGCTGATTCCCTGTTGGGCGGGCTGGAGGCGGACAGCTTGCAGGGCGACGCCGGCGACGACACGCTGCATGGCGG
CTCCGGCGCAGATGTGGTCGCGGGCGGCGCGGGCAGCGATGCGGTGCATGGCAACGACGATGACGACCGTGTGTTTGGCG
GCGCGGGCGAGGACACGCTGTTTGGCGGGCGTGGCAATGACGTGGTCACGGGCGCAGACGACGATGCAGAGCGCGACTTT
ATCAACGGCGGTGACGGCGACGACACGTTGATTGCCGGGGCGTCGGATTACGTCACAGGTGGCGATGGCGCGGACCAGAT
ACTGCTTGGCGATTGGATCGCACAAGGCACTGTCGAGCTGGTCGATTTCAACAGCGCCGAGGATCAGCTCCTCCTGATCT
ATGATAGCGCGCAGGGTCTGCCCGAGCTGGAGCTCGAACCCGACCCGGACACGCCGGGACAGACACTTGTGCGTCTGGAC
GGAGAGATCGCCATGCGCCTCACCGGGGCTGAGACCCTGACAGCAGATGAGATCTTGCTGGTGGAGGCCGAGGCGGGCGA
CGTGGCGCATCTGCCATTGCCAGAATAG

Upstream 100 bases:

>100_bases
CTACATGTAACTGCGTTCCTGTTTTGTTTAGAGTTTGGCCATCTCTTTGTGAGAGGCTCTCCCTCGTTAAAGAGTGTCTG
AAACGAAGTGGACCGGTGCC

Downstream 100 bases:

>100_bases
GGTAGCAACTGTGCCCATCGCGTATCCCGAGGCTGTTGGACAAAGGGTGTCGAATGGCTTCTGTTGAGAAAACACCAGCA
GACGGGTGCTTACCCCCTCT

Product: type I secretion target repeat-containing protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLWLASILGMVAVGSAIMIDFESDDADSDETNPDAEADGTGSTIVSPDEFLTGVDPAGNDASDTTETDESPQVADGDDTD
ERNIILGTEDLDQLSGGATDDEISGLGGDDQINGYDGNDYLSGGAGADDLYGAAGEDTLHGDAGDDHLDGGEGQDSLSGG
DGADSLLGGLEADSLQGDAGDDTLHGGSGADVVAGGAGSDAVHGNDDDDRVFGGAGEDTLFGGRGNDVVTGADDDAERDF
INGGDGDDTLIAGASDYVTGGDGADQILLGDWIAQGTVELVDFNSAEDQLLLIYDSAQGLPELELEPDPDTPGQTLVRLD
GEIAMRLTGAETLTADEILLVEAEAGDVAHLPLPE

Sequences:

>Translated_355_residues
MLWLASILGMVAVGSAIMIDFESDDADSDETNPDAEADGTGSTIVSPDEFLTGVDPAGNDASDTTETDESPQVADGDDTD
ERNIILGTEDLDQLSGGATDDEISGLGGDDQINGYDGNDYLSGGAGADDLYGAAGEDTLHGDAGDDHLDGGEGQDSLSGG
DGADSLLGGLEADSLQGDAGDDTLHGGSGADVVAGGAGSDAVHGNDDDDRVFGGAGEDTLFGGRGNDVVTGADDDAERDF
INGGDGDDTLIAGASDYVTGGDGADQILLGDWIAQGTVELVDFNSAEDQLLLIYDSAQGLPELELEPDPDTPGQTLVRLD
GEIAMRLTGAETLTADEILLVEAEAGDVAHLPLPE
>Mature_355_residues
MLWLASILGMVAVGSAIMIDFESDDADSDETNPDAEADGTGSTIVSPDEFLTGVDPAGNDASDTTETDESPQVADGDDTD
ERNIILGTEDLDQLSGGATDDEISGLGGDDQINGYDGNDYLSGGAGADDLYGAAGEDTLHGDAGDDHLDGGEGQDSLSGG
DGADSLLGGLEADSLQGDAGDDTLHGGSGADVVAGGAGSDAVHGNDDDDRVFGGAGEDTLFGGRGNDVVTGADDDAERDF
INGGDGDDTLIAGASDYVTGGDGADQILLGDWIAQGTVELVDFNSAEDQLLLIYDSAQGLPELELEPDPDTPGQTLVRLD
GEIAMRLTGAETLTADEILLVEAEAGDVAHLPLPE

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 35814; Mature: 35814

Theoretical pI: Translated: 3.13; Mature: 3.13

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWLASILGMVAVGSAIMIDFESDDADSDETNPDAEADGTGSTIVSPDEFLTGVDPAGND
CHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEECHHHHHCCCCCCCCC
ASDTTETDESPQVADGDDTDERNIILGTEDLDQLSGGATDDEISGLGGDDQINGYDGNDY
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCHHHCCCCCCCCCCCCCCCCC
LSGGAGADDLYGAAGEDTLHGDAGDDHLDGGEGQDSLSGGDGADSLLGGLEADSLQGDAG
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
DDTLHGGSGADVVAGGAGSDAVHGNDDDDRVFGGAGEDTLFGGRGNDVVTGADDDAERDF
CCCCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCEECCCCCCEEECCCCCHHHCC
INGGDGDDTLIAGASDYVTGGDGADQILLGDWIAQGTVELVDFNSAEDQLLLIYDSAQGL
CCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHCCCEEEEEECCCCCCCEEEEEECCCCC
PELELEPDPDTPGQTLVRLDGEIAMRLTGAETLTADEILLVEAEAGDVAHLPLPE
CCCCCCCCCCCCCCEEEEECCEEEEEEECCCEECCCEEEEEEECCCCEECCCCCC
>Mature Secondary Structure
MLWLASILGMVAVGSAIMIDFESDDADSDETNPDAEADGTGSTIVSPDEFLTGVDPAGND
CHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEECHHHHHCCCCCCCCC
ASDTTETDESPQVADGDDTDERNIILGTEDLDQLSGGATDDEISGLGGDDQINGYDGNDY
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCHHHCCCCCCCCCCCCCCCCC
LSGGAGADDLYGAAGEDTLHGDAGDDHLDGGEGQDSLSGGDGADSLLGGLEADSLQGDAG
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
DDTLHGGSGADVVAGGAGSDAVHGNDDDDRVFGGAGEDTLFGGRGNDVVTGADDDAERDF
CCCCCCCCCCCEEECCCCCCCCCCCCCCCEEECCCCCCCEECCCCCCEEECCCCCHHHCC
INGGDGDDTLIAGASDYVTGGDGADQILLGDWIAQGTVELVDFNSAEDQLLLIYDSAQGL
CCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHCCCEEEEEECCCCCCCEEEEEECCCCC
PELELEPDPDTPGQTLVRLDGEIAMRLTGAETLTADEILLVEAEAGDVAHLPLPE
CCCCCCCCCCCCCCEEEEECCEEEEEEECCCEECCCEEEEEEECCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]