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The map label for this gene is cadC [H]

Identifier: 94995331

GI number: 94995331

Start: 1890069

End: 1890437

Strand: Direct

Name: cadC [H]

Synonym: MGAS10750_Spy1935

Alternate gene names: 94995331

Gene position: 1890069-1890437 (Clockwise)

Preceding gene: 94995330

Following gene: 94995332

Centisome position: 97.57

GC content: 32.52

Gene sequence:

>369_bases
ATGGGCTGTGTTAGGCTAGGAGAAAATATTATGAAAAAAGATAGTATCTGCCAAGTGAATGTTATAAATCAACAAAATGT
TATAACCGCAACGAACTACCTTGAAAAGGAAAAAGTCCAAAAATCACTTCGTATTTTATCAAAGTTTACCGATAATAAAC
AGATAAATATCATCTTTTATCTCCTTACTGTTGAAGAACTCTGTGTCTGCGATATAGCCTGTTTACTAAATCTCAGTATG
GCATCTGCCTCCCACCATCTTCGTAAACTAGCCAATCAAAACATCTTGGACACTAGAAGAGAGGGGAAAATTATATATTA
TTTTATAAAAGATGAGGAAATCAGAGATTTTTTTAATCAACTAGGATAA

Upstream 100 bases:

>100_bases
TTGGAGAAATTTTGGAAAAATATAGCAGATGGTTTATTGCCGTTGTTTATTTAGGATTGGGGATATATATCCTGATTGAA
AACAACAGTTTTGACATGCT

Downstream 100 bases:

>100_bases
CAACTATTTTTACCACTTTTCCATGTTTATAGGGGGCTTATCTATGAAATTTTTTGATGAAAATTACTCACAAGAAATAC
CTACTCGTATCAAATGTTTA

Product: Cadmium efflux system accessory protein

Products: NA

Alternate protein names: Cadmium resistance regulatory protein [H]

Number of amino acids: Translated: 122; Mature: 121

Protein sequence:

>122_residues
MGCVRLGENIMKKDSICQVNVINQQNVITATNYLEKEKVQKSLRILSKFTDNKQINIIFYLLTVEELCVCDIACLLNLSM
ASASHHLRKLANQNILDTRREGKIIYYFIKDEEIRDFFNQLG

Sequences:

>Translated_122_residues
MGCVRLGENIMKKDSICQVNVINQQNVITATNYLEKEKVQKSLRILSKFTDNKQINIIFYLLTVEELCVCDIACLLNLSM
ASASHHLRKLANQNILDTRREGKIIYYFIKDEEIRDFFNQLG
>Mature_121_residues
GCVRLGENIMKKDSICQVNVINQQNVITATNYLEKEKVQKSLRILSKFTDNKQINIIFYLLTVEELCVCDIACLLNLSMA
SASHHLRKLANQNILDTRREGKIIYYFIKDEEIRDFFNQLG

Specific function: Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Metal binding causes the repressor to dissociate from the DNA [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 14159; Mature: 14028

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS00846 HTH_ARSR_1 ; PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGCVRLGENIMKKDSICQVNVINQQNVITATNYLEKEKVQKSLRILSKFTDNKQINIIFY
CCCHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LLTVEELCVCDIACLLNLSMASASHHLRKLANQNILDTRREGKIIYYFIKDEEIRDFFNQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHH
LG
CC
>Mature Secondary Structure 
GCVRLGENIMKKDSICQVNVINQQNVITATNYLEKEKVQKSLRILSKFTDNKQINIIFY
CCHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LLTVEELCVCDIACLLNLSMASASHHLRKLANQNILDTRREGKIIYYFIKDEEIRDFFNQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHH
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8188605; 8188606 [H]