Click here to switch to the map view.

The map label for this gene is ahpC [H]

Identifier: 94995256

GI number: 94995256

Start: 1818485

End: 1819045

Strand: Direct

Name: ahpC [H]

Synonym: MGAS10750_Spy1860

Alternate gene names: 94995256

Gene position: 1818485-1819045 (Clockwise)

Preceding gene: 94995248

Following gene: 94995257

Centisome position: 93.88

GC content: 39.22

Gene sequence:

>561_bases
ATGTCTCTAATTGGAAAAGAAATTGCTGAATTTTCAGCTCAAGCTTATCACGATGGAAAATTCATCACTGTTACAAATGA
AGACGTTAAAGGAAAATGGGCAGTTTTTTGTTTCTACCCAGCAGACTTTTCATTTGTTTGCCCAACTGAACTCGGTGACC
TTCAAAAGCAATACGAAACACTGAAATCTCTTGGTGTAGAAGTTTATTCTGTCTCTACTGATACTCATTTTGTTCATAAA
GCTTGGCATGATGATTCAGATGTGGTTGGCACTATCACATACCCTATGATTGGTGACCCTTCACACCTTATTTCACAAGC
CTTTGAAGTGCTTGGCGAAGACGGACTTGCTCAACGTGGAACATTTATCGTTGATCCAGATGGTATTATCCAAATGATGG
AAATTAATGCTGATGGTATTGGACGTGACGCTAGCACCTTGATTGATAAAATTCACGCTGCCCAATACGTCCGTAAACAT
CCAGGTGAAGTTTGTCCAGCTAAATGGAAAGAAGGCGCTGAAACTTTGACACCAAGTCTTGATTTAGTTGGTAAAATTTA
A

Upstream 100 bases:

>100_bases
ATCGCTGATTTCCCAGTAAAATCAAGGGTTTCTGAGTAGACATAATCTTGTTGTTCTTTTATAATACAAGTATAAAACTA
TAAAAAAGGAGGACAACTAT

Downstream 100 bases:

>100_bases
TAAATTTTAGGAGGAAAGCTATGGCATTAAGTCCTGATATTAAAGAACAACTTGCCCAATACCTCACCCTGTTAGAAGCT
GATCTTGTTTTGCAAGTTTC

Product: Peroxiredoxin

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; General stress protein 22; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQKQYETLKSLGVEVYSVSTDTHFVHK
AWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKH
PGEVCPAKWKEGAETLTPSLDLVGKI

Sequences:

>Translated_186_residues
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQKQYETLKSLGVEVYSVSTDTHFVHK
AWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKH
PGEVCPAKWKEGAETLTPSLDLVGKI
>Mature_185_residues
SLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQKQYETLKSLGVEVYSVSTDTHFVHKA
WHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKHP
GEVCPAKWKEGAETLTPSLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=182, Percent_Identity=39.5604395604396, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4505591, Length=182, Percent_Identity=39.010989010989, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI32455266, Length=182, Percent_Identity=39.010989010989, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI32455264, Length=182, Percent_Identity=39.010989010989, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI5453549, Length=187, Percent_Identity=39.0374331550802, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=38.150289017341, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=38.150289017341, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=46.3414634146341, Blast_Score=81, Evalue=7e-16,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=62.5668449197861, Blast_Score=253, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=39.8907103825137, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=39.8907103825137, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=37.8531073446328, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=32.972972972973, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=33.7016574585635, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17738015, Length=172, Percent_Identity=38.3720930232558, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357347, Length=189, Percent_Identity=35.4497354497354, Blast_Score=126, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24656348, Length=182, Percent_Identity=35.1648351648352, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17864676, Length=182, Percent_Identity=35.1648351648352, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=33.8888888888889, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=33.8888888888889, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=26.5822784810127, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20482; Mature: 20351

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQKQYET
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCEECCCHHHHHHHHHHH
LKSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRG
HHHCCEEEEEECCCCCEEHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
TFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKHPGEVCPAKWKEGAETLTPSL
CEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCCH
DLVGKI
HHCCCC
>Mature Secondary Structure 
SLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQKQYET
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCEECCCHHHHHHHHHHH
LKSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRG
HHHCCEEEEEECCCCCEEHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
TFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKHPGEVCPAKWKEGAETLTPSL
CEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCCH
DLVGKI
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8180695; 8012595 [H]