| Definition | Streptococcus pyogenes MGAS10750 chromosome, complete genome. |
|---|---|
| Accession | NC_008024 |
| Length | 1,937,111 |
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The map label for this gene is pfl [H]
Identifier: 94995024
GI number: 94995024
Start: 1564906
End: 1567260
Strand: Direct
Name: pfl [H]
Synonym: MGAS10750_Spy1628
Alternate gene names: 94995024
Gene position: 1564906-1567260 (Clockwise)
Preceding gene: 94995022
Following gene: 94995027
Centisome position: 80.79
GC content: 41.78
Gene sequence:
>2355_bases TTGTTACTAGAATTTAAGGAGAAATTTATGGCAACTGTTAAAACCAATACAGATGTTTTCGAAAAAGCTTGGGAAGGCTT TAAAGGAACTGACTGGAAAGAAAAAGCAAGTGTCTCACGTTTTGTACAAGCTAACTACACCCCATACGATGGCGATGAAT CTTTCTTGGCTGGTGCTACTGAACGCTCACTTCACATCAAAAAAGTTATCGAAGAAACAAAAGCACACTATGAAGCTACA CGTTTCCCATACGATACTCGTCCAACTTCAATTGCTGACATTCCTGCTGGTTTCATCGATAAAGAAAATGAATTAATTTA TGGTATTCAAAACGATGAATTGTTCAAATTGAACTTCATGCCAAAAGGTGGTATCCGTATGGCGGAAACGACCCTTAAAG AAAACGGCTATGAACCAGACCCAGCAGTACATGAAATCTTTACTAAGTATGTGACAACTGTTAACGACGGTATCTTCCGC GCTTATACTTCAAATATTCGTCGCGCTCGTCATGCCCACACTGTAACTGGTCTTCCAGATGCTTACTCACGTGGACGTAT CATCGGTGTTTACGCTCGTCTTGCTCTTTACGGTGCTGACTACTTGATGCAAGAAAAAGTCAATGACTGGAATGCTATCA CTGAAATCGATGAAGAATCCATTCGTCTTCGCGAAGAAGTTAACCTTCAATACCAAGCTCTTGGTGAAGTGGTTAAACTT GGTGACCTTTACGGAGTTGATGTTCGTCGCCCAGCACAAAACGTTAAAGAAGCTATCCAATGGGTAAACATCGCTTTCAT GGCTGTATGTCGTGTGATCAACGGTGCTGCTACTTCTCTTGGACGTGTGCCAATCGTTCTTGATATCTTTGCAGAACGTG ACCTTGCTCGCGGTACCTTTACAGAATCAGAAATCCAAGAATTTGTTGATGATTTTGTCCTTAAACTCCGTACCGTAAAA TTTGGTCGTACTAAAGCTTACGATGCCCTTTACTCAGGTGACCCAACATTCATCACAACTTCTATGGCTGGTATGGGTAA CGACGGTCGTCACCGTGTGACTAAGATGGACTACCGTTTCTTAAACACTCTTGATAATATCGGTAACTCTCCAGAACCAA ACTTAACAGTTCTTTGGACTGACCAACTGCCAGAAACATTCCGTCGCTACTGTATGAAAATGAGCCACAAACACTCTTCT ATCCAATATGAAGGTGTGACAACAATGGCTAAAGAAGGTTATGGTGAGATGTCATGTATTTCATGTTGTGTATCACCACT TGACCCAGAAAATGAAGAACAACGTCATAACATCCAATACTTCGGTGCTCGCGTAAACGTTCTTAAAGCCCTTCTTACTG GTCTTAACGGTGGTTACGATGATGTTCACAGAGACTACAAAGTGTTTAACGTTGTTGAACCAATCACATCAGAAGTTCTT GAGTACGACGAAGTTATGGCTAACTTTGAGAAATCTCTTGACTGGTTGACAGATACTTATGTAGATGCGCTTAACATCAT CCACTACATGACTGATAAATACAACTACGAAGCAGTTCAAATGGCCTTCTTGCCAACACACCAACGTGCTAACATGGGAT TCGGTATCTGTGGTTTCGCTAACACAGTTGATACCTTGTCAGCTATTAAATACGCAACTGTTAAAACTATCCGCGATGAA AATGGCTACATCTATGACTACGAAGTAACAGGTGACTTCCCTCGTTACGGTGAAGATGACGACCGTGTTGATGACATCGC GAAATGGTTGATGGAAGCTTACCACACACGTCTTGCAAGCCACAAACTTTACAAGAATGCTGAGGCTTCAGTATCACTTC TTACCATCACTTCAAACGTTGCTTACTCTAAACAAACTGGTAACTCTCCAGTCCACCGCGGCGTCTTCTTGAACGAAGAT GGTACAGTTAACACTAGCCAAGTGGAATTCTTCTCACCAGGTGCTAACCCATCTAACAAAGCAAAAGGTGGCTGGTTACA AAACCTTAACTCACTTGCTAAACTGGAATTCTCACATGCTAACGATGGTATCTCATTGACTACTCAAGTATCACCTCGTG CTCTTGGTAAAACATTTGACGAACAAGTTGACAACTTGGTAACAGTGCTTGACGGTTACTTTGAAAATGGTGGTCAGCAC GTTAACTTGAACGTTATGGACCTTAACGATGTTTATGACAAAATCATGAACGGCGAAGACGTTATCGTACGTATCTCTGG TTACTGTGTCAACACCAAATACCTTACACCAGAACAAAAAACTGAGTTGACACAACGTGTCTTCCACGAAGTGCTTTCCA TGGACGATGCTGCTGAAGCTATTTCAAGTAAATAG
Upstream 100 bases:
>100_bases ACAATCTGTATTATAAAAGAATCTTAATTTTGTCAAGAATTTTGCTTGGGAAAACGTTTCCTATGTGTTAAACTTAGAAT TGTAAATGTAACAGATCGCT
Downstream 100 bases:
>100_bases TAGTATCTAAATGATCAATAACTTATAAAAAAGAACAGCCATCTCATTTGATTCAAAATGAGATGGCTATTCTTTTTTCA CTTATAATCACTCTAATCGC
Product: Formate acetyltransferase
Products: NA
Alternate protein names: Pyruvate formate-lyase [H]
Number of amino acids: Translated: 784; Mature: 784
Protein sequence:
>784_residues MLLEFKEKFMATVKTNTDVFEKAWEGFKGTDWKEKASVSRFVQANYTPYDGDESFLAGATERSLHIKKVIEETKAHYEAT RFPYDTRPTSIADIPAGFIDKENELIYGIQNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFR AYTSNIRRARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAITEIDEESIRLREEVNLQYQALGEVVKL GDLYGVDVRRPAQNVKEAIQWVNIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTESEIQEFVDDFVLKLRTVK FGRTKAYDALYSGDPTFITTSMAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDQLPETFRRYCMKMSHKHSS IQYEGVTTMAKEGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNGGYDDVHRDYKVFNVVEPITSEVL EYDEVMANFEKSLDWLTDTYVDALNIIHYMTDKYNYEAVQMAFLPTHQRANMGFGICGFANTVDTLSAIKYATVKTIRDE NGYIYDYEVTGDFPRYGEDDDRVDDIAKWLMEAYHTRLASHKLYKNAEASVSLLTITSNVAYSKQTGNSPVHRGVFLNED GTVNTSQVEFFSPGANPSNKAKGGWLQNLNSLAKLEFSHANDGISLTTQVSPRALGKTFDEQVDNLVTVLDGYFENGGQH VNLNVMDLNDVYDKIMNGEDVIVRISGYCVNTKYLTPEQKTELTQRVFHEVLSMDDAAEAISSK
Sequences:
>Translated_784_residues MLLEFKEKFMATVKTNTDVFEKAWEGFKGTDWKEKASVSRFVQANYTPYDGDESFLAGATERSLHIKKVIEETKAHYEAT RFPYDTRPTSIADIPAGFIDKENELIYGIQNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFR AYTSNIRRARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAITEIDEESIRLREEVNLQYQALGEVVKL GDLYGVDVRRPAQNVKEAIQWVNIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTESEIQEFVDDFVLKLRTVK FGRTKAYDALYSGDPTFITTSMAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDQLPETFRRYCMKMSHKHSS IQYEGVTTMAKEGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNGGYDDVHRDYKVFNVVEPITSEVL EYDEVMANFEKSLDWLTDTYVDALNIIHYMTDKYNYEAVQMAFLPTHQRANMGFGICGFANTVDTLSAIKYATVKTIRDE NGYIYDYEVTGDFPRYGEDDDRVDDIAKWLMEAYHTRLASHKLYKNAEASVSLLTITSNVAYSKQTGNSPVHRGVFLNED GTVNTSQVEFFSPGANPSNKAKGGWLQNLNSLAKLEFSHANDGISLTTQVSPRALGKTFDEQVDNLVTVLDGYFENGGQH VNLNVMDLNDVYDKIMNGEDVIVRISGYCVNTKYLTPEQKTELTQRVFHEVLSMDDAAEAISSK >Mature_784_residues MLLEFKEKFMATVKTNTDVFEKAWEGFKGTDWKEKASVSRFVQANYTPYDGDESFLAGATERSLHIKKVIEETKAHYEAT RFPYDTRPTSIADIPAGFIDKENELIYGIQNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFR AYTSNIRRARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNAITEIDEESIRLREEVNLQYQALGEVVKL GDLYGVDVRRPAQNVKEAIQWVNIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTESEIQEFVDDFVLKLRTVK FGRTKAYDALYSGDPTFITTSMAGMGNDGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWTDQLPETFRRYCMKMSHKHSS IQYEGVTTMAKEGYGEMSCISCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNGGYDDVHRDYKVFNVVEPITSEVL EYDEVMANFEKSLDWLTDTYVDALNIIHYMTDKYNYEAVQMAFLPTHQRANMGFGICGFANTVDTLSAIKYATVKTIRDE NGYIYDYEVTGDFPRYGEDDDRVDDIAKWLMEAYHTRLASHKLYKNAEASVSLLTITSNVAYSKQTGNSPVHRGVFLNED GTVNTSQVEFFSPGANPSNKAKGGWLQNLNSLAKLEFSHANDGISLTTQVSPRALGKTFDEQVDNLVTVLDGYFENGGQH VNLNVMDLNDVYDKIMNGEDVIVRISGYCVNTKYLTPEQKTELTQRVFHEVLSMDDAAEAISSK
Specific function: Glucose metabolism (nonoxidative conversion). [C]
COG id: COG1882
COG function: function code C; Pyruvate-formate lyase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 pyruvate formate lyase domain [H]
Homologues:
Organism=Escherichia coli, GI1787131, Length=770, Percent_Identity=43.8961038961039, Blast_Score=618, Evalue=1e-178, Organism=Escherichia coli, GI48994926, Length=779, Percent_Identity=42.3620025673941, Blast_Score=594, Evalue=1e-171,
Paralogues:
None
Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005949 - InterPro: IPR001150 - InterPro: IPR019777 - InterPro: IPR004184 [H]
Pfam domain/function: PF01228 Gly_radical; PF02901 PFL [H]
EC number: =2.3.1.54 [H]
Molecular weight: Translated: 88696; Mature: 88696
Theoretical pI: Translated: 4.88; Mature: 4.88
Prosite motif: PS00850 GLY_RADICAL_1 ; PS51149 GLY_RADICAL_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLLEFKEKFMATVKTNTDVFEKAWEGFKGTDWKEKASVSRFVQANYTPYDGDESFLAGAT CCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCC ERSLHIKKVIEETKAHYEATRFPYDTRPTSIADIPAGFIDKENELIYGIQNDELFKLNFM HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCEEEEEEC PKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIRRARHAHTVTGLPD CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC AYSRGRIIGVYARLALYGADYLMQEKVNDWNAITEIDEESIRLREEVNLQYQALGEVVKL HHHCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHH GDLYGVDVRRPAQNVKEAIQWVNIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTF CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCCCCC TESEIQEFVDDFVLKLRTVKFGRTKAYDALYSGDPTFITTSMAGMGNDGRHRVTKMDYRF CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHH LNTLDNIGNSPEPNLTVLWTDQLPETFRRYCMKMSHKHSSIQYEGVTTMAKEGYGEMSCI HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCHHHH SCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNGGYDDVHRDYKVFNVVEPITSEVL HHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHH EYDEVMANFEKSLDWLTDTYVDALNIIHYMTDKYNYEAVQMAFLPTHQRANMGFGICGFA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEECCCH NTVDTLSAIKYATVKTIRDENGYIYDYEVTGDFPRYGEDDDRVDDIAKWLMEAYHTRLAS HHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH HKLYKNAEASVSLLTITSNVAYSKQTGNSPVHRGVFLNEDGTVNTSQVEFFSPGANPSNK HHHHCCCCCCEEEEEEECCCEECCCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCC AKGGWLQNLNSLAKLEFSHANDGISLTTQVSPRALGKTFDEQVDNLVTVLDGYFENGGQH CCCCHHHHHHHHHHEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE VNLNVMDLNDVYDKIMNGEDVIVRISGYCVNTKYLTPEQKTELTQRVFHEVLSMDDAAEA EEEEEEEHHHHHHHHCCCCEEEEEEEEEEEECEECCCHHHHHHHHHHHHHHHCCCHHHHH ISSK HCCC >Mature Secondary Structure MLLEFKEKFMATVKTNTDVFEKAWEGFKGTDWKEKASVSRFVQANYTPYDGDESFLAGAT CCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCC ERSLHIKKVIEETKAHYEATRFPYDTRPTSIADIPAGFIDKENELIYGIQNDELFKLNFM HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCEEEEEEC PKGGIRMAETTLKENGYEPDPAVHEIFTKYVTTVNDGIFRAYTSNIRRARHAHTVTGLPD CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC AYSRGRIIGVYARLALYGADYLMQEKVNDWNAITEIDEESIRLREEVNLQYQALGEVVKL HHHCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHH GDLYGVDVRRPAQNVKEAIQWVNIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTF CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCCCCC TESEIQEFVDDFVLKLRTVKFGRTKAYDALYSGDPTFITTSMAGMGNDGRHRVTKMDYRF CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHH LNTLDNIGNSPEPNLTVLWTDQLPETFRRYCMKMSHKHSSIQYEGVTTMAKEGYGEMSCI HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCHHHH SCCVSPLDPENEEQRHNIQYFGARVNVLKALLTGLNGGYDDVHRDYKVFNVVEPITSEVL HHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHH EYDEVMANFEKSLDWLTDTYVDALNIIHYMTDKYNYEAVQMAFLPTHQRANMGFGICGFA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEECCCH NTVDTLSAIKYATVKTIRDENGYIYDYEVTGDFPRYGEDDDRVDDIAKWLMEAYHTRLAS HHHHHHHHHHHHHHHEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH HKLYKNAEASVSLLTITSNVAYSKQTGNSPVHRGVFLNEDGTVNTSQVEFFSPGANPSNK HHHHCCCCCCEEEEEEECCCEECCCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCC AKGGWLQNLNSLAKLEFSHANDGISLTTQVSPRALGKTFDEQVDNLVTVLDGYFENGGQH CCCCHHHHHHHHHHEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE VNLNVMDLNDVYDKIMNGEDVIVRISGYCVNTKYLTPEQKTELTQRVFHEVLSMDDAAEA EEEEEEEHHHHHHHHCCCCEEEEEEEEEEEECEECCCHHHHHHHHHHHHHHHCCCHHHHH ISSK HCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8550181; 12397186 [H]