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The map label for this gene is pyrD [H]

Identifier: 94994669

GI number: 94994669

Start: 1217208

End: 1218155

Strand: Direct

Name: pyrD [H]

Synonym: MGAS10750_Spy1273

Alternate gene names: 94994669

Gene position: 1217208-1218155 (Clockwise)

Preceding gene: 94994659

Following gene: 94994722

Centisome position: 62.84

GC content: 41.56

Gene sequence:

>948_bases
ATGGAGGAAATAATGGTTTCTACTGCTACACAAATTGGTCATTTCTCTTTTGATAACTGTTTGATGAATGCTGCTGGTGT
TTACTGCATGACAAAAGAAGAGCTTATGGAGGTTGAAAAGTCTCAAGCCGCTTCCTTTGTCACCAAAACAGGGACGCTTG
AAGTTCGTCCAGGTAATCCAGAACCTCGCTACGCAGATACTCGTCTTGGTTCTATCAATTCAATGGGACTCCCTAATAAT
GGTTTTCGCTACTACTTAGACTTTGTCAGTGATCTTGCCAAAACCGGGCAACATAAACCTCACTTTCTCTCCGTTGTCGG
GCTATCTCCTACTGAAACCGAAACCATTTTAAAAGCCATCATGGCTTCAGATTATGAGGGTCTAGTGGAACTAAACCTTT
CTTGCCCTAACGTTCCAGGAAAACCACAGATTGCTTATGATTTTGAAACCACTGATCAACTTCTAGAGAACATCTTTACC
TATTACACTAAACCTCTTGGTATCAAATTACCTCCTTATTTTGACATTGTGCATTTTGATCAAGCGGCTGCGATTTTCAA
TAAATACCCCCTTTCCTTTGTTAACTGTGTCAATTCTATCGGAAATGGGCTGGTCATTGAGGATGAGCAAGTCCTCATCA
AGCCTAAAAATGGCTTTGGTGGTATAGGTGGAGATTACATCAAACCTACTGCTCTAGCCAATGTCCATGCGTTTTACAAA
CGCTTAAAACCTTCTATCCACATTATTGGTACAGGGGGAGTTAAAACAGGACGCGATGCCTTTGAACATATTCTTTGTGG
CGCCAGCATGGTCCAAATTGGGACAGCCCTTCATCAAGAAGGGCCAGCTATCTTTGAACGGGTCACTAAGGAACTAAAAA
CGATTATGGTAGAAAAAGGCTACCAAAGCTTAGACGATTTTCGTGGGAACTTACGTTACAAAGATTAA

Upstream 100 bases:

>100_bases
TTCAAATGTTCGTTAATAACAGTAATATATTTACATTTTTGTAAAAATAGCTTGCTATTATTCATGCCTAGTGGTAGAAT
AGAAAAAATTTGTCTAAAAT

Downstream 100 bases:

>100_bases
CCTTAATAGTCAAAAAAGCTTGGAAATGTGCACTTTGTACACTTTCCAAGCTTTTTAAAATGGGAATTTTTTTGAAGGGA
CAGCGTCACTTTCTTGGGAC

Product: dihydroorotate dehydrogenase 1A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MEEIMVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNN
GFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFT
YYTKPLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYK
RLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD

Sequences:

>Translated_315_residues
MEEIMVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNN
GFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFT
YYTKPLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYK
RLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD
>Mature_315_residues
MEEIMVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNPEPRYADTRLGSINSMGLPNN
GFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAIMASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFT
YYTKPLGIKLPPYFDIVHFDQAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYK
RLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKGYQSLDDFRGNLRYKD

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082059, Length=218, Percent_Identity=26.1467889908257, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=311, Percent_Identity=58.1993569131833, Blast_Score=382, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281361352, Length=287, Percent_Identity=28.2229965156794, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17137316, Length=287, Percent_Identity=28.2229965156794, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 34826; Mature: 34826

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEIMVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNP
CCCHHHHHHHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEECCCC
EPRYADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHH
MASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTKPLGIKLPPYFDIVHFD
HHCCCCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHH
QAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYK
HHHHHHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKG
HCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
YQSLDDFRGNLRYKD
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MEEIMVSTATQIGHFSFDNCLMNAAGVYCMTKEELMEVEKSQAASFVTKTGTLEVRPGNP
CCCHHHHHHHHHCCCCHHHHHHHCCCEEEECHHHHHHHHHHHHHHHEEECCEEEEECCCC
EPRYADTRLGSINSMGLPNNGFRYYLDFVSDLAKTGQHKPHFLSVVGLSPTETETILKAI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHH
MASDYEGLVELNLSCPNVPGKPQIAYDFETTDQLLENIFTYYTKPLGIKLPPYFDIVHFD
HHCCCCCEEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHH
QAAAIFNKYPLSFVNCVNSIGNGLVIEDEQVLIKPKNGFGGIGGDYIKPTALANVHAFYK
HHHHHHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RLKPSIHIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPAIFERVTKELKTIMVEKG
HCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
YQSLDDFRGNLRYKD
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]