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The map label for this gene is guaC [H]

Identifier: 94994402

GI number: 94994402

Start: 953921

End: 954925

Strand: Direct

Name: guaC [H]

Synonym: MGAS10750_Spy1006

Alternate gene names: 94994402

Gene position: 953921-954925 (Clockwise)

Preceding gene: 94994401

Following gene: 94994403

Centisome position: 49.24

GC content: 39.3

Gene sequence:

>1005_bases
GTGCTAAAAGAGGAGAAACTTATGTTTAATGACATCCCTGTATTTGATTATGAAGATATTCAACTGATTCCTAACAAGTG
CATTATTACTAGTCGTTCACAAGCAGATACAAGTGTGACACTCGGAAAATACCAGTTCAAGCTACCAGTTATCCCAGCAA
ATATGCAAACCATTATTGATGAAACAATTGCTGAGCAATTGGCAAAAGAGGGTTATTTTTATATTATGCATCGTTTTGAT
GAAGATAGCCGCAAACCTTTTATCAAACGCATGCATGAACAAGGCTTGATTGCATCCATCTCTGTTGGGGTTAAAGCTTA
CGAATATGAATTTGTGACTTCTTTGAAAGAGGATACTCCTGAGTTTATCACCATTGATATTGCTCATGGTCATGCTAACA
GTGTTATTGATATGATTAAGCATATCAAAACTGAATTACCAGAAACATTTGTCATTGCTGGAAATGTTGGTACGCCAGAA
GCTGTACGAGAACTCGAAAATGCAGGTGCTGATGCTACTAAAGTAGGCATCGGTCCAGGCAAAGTATGTATCACTAAAGT
TAAAACAGGTTTCGGTACAGGTGGTTGGCAGTTAGCAGCACTGCGCTGGTGCGCAAAGGCAGCTCGTAAGCCTATCATTG
CTGATGGTGGGATTCGCACACATGGTGATATCGCTAAATCCATCCGCTTTGGAGCTAGTATGGTCATGATTGGTTCGCTT
TTTGCAGGGCATATTGAAAGTCCTGGAAAAACAGTAGAAGTGAATGGTGAAACGTTTAAAGAATATTATGGCTCGGCGTC
AGCATATCAAAAAGGCGAGCATAAAAATGTAGAAGGCAAAAAAATCTTATTGCCTACAAAAGGTCACTTATCAGATACCC
TGACCGAAATGCAACAGGATTTGCAATCGTCCATTTCTTACGCGGGTGGTAAAGATTTAGACAGTTTGCGTCATGTTGAT
TATGTTATCGTCAAAAATTCTATTTGGAATGGTGATTCCATTTAA

Upstream 100 bases:

>100_bases
TTTACCTAAAGATACCTCTAATCATCAGAGGTCATAGGAAGATTATTTTGTATAGAGGACTTAGAGAAGAAGGTGAGAAC
TGACTTATTTTCTTTCATCT

Downstream 100 bases:

>100_bases
ATGATATGGAGTTAGCTAGGACCAGTAAAGAATTTTTTAGCTTAATGCTGGAGATGCTTTTATCATATCTCTGTAGGTAT
TGAAAAAAATAAGAAACATG

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLKEEKLMFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFD
EDSRKPFIKRMHEQGLIASISVGVKAYEYEFVTSLKEDTPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPE
AVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSL
FAGHIESPGKTVEVNGETFKEYYGSASAYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVD
YVIVKNSIWNGDSI

Sequences:

>Translated_334_residues
MLKEEKLMFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFD
EDSRKPFIKRMHEQGLIASISVGVKAYEYEFVTSLKEDTPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPE
AVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSL
FAGHIESPGKTVEVNGETFKEYYGSASAYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVD
YVIVKNSIWNGDSI
>Mature_334_residues
MLKEEKLMFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIIDETIAEQLAKEGYFYIMHRFD
EDSRKPFIKRMHEQGLIASISVGVKAYEYEFVTSLKEDTPEFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPE
AVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSL
FAGHIESPGKTVEVNGETFKEYYGSASAYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQDLQSSISYAGGKDLDSLRHVD
YVIVKNSIWNGDSI

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI156104880, Length=329, Percent_Identity=34.0425531914894, Blast_Score=175, Evalue=4e-44,
Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=32.5443786982249, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=32.5443786982249, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=32.5443786982249, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=32.5443786982249, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI66933016, Length=303, Percent_Identity=29.3729372937294, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI217035150, Length=263, Percent_Identity=31.5589353612167, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI217035148, Length=263, Percent_Identity=31.5589353612167, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI217035146, Length=263, Percent_Identity=31.5589353612167, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI34328930, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156616279, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI34328928, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI217035152, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786293, Length=337, Percent_Identity=32.9376854599407, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788855, Length=256, Percent_Identity=35.15625, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560440, Length=326, Percent_Identity=32.8220858895706, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71994385, Length=176, Percent_Identity=35.2272727272727, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=176, Percent_Identity=35.2272727272727, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323585, Length=185, Percent_Identity=34.0540540540541, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323464, Length=181, Percent_Identity=34.2541436464088, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322012, Length=188, Percent_Identity=32.9787234042553, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319352, Length=136, Percent_Identity=30.8823529411765, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28571163, Length=247, Percent_Identity=31.5789473684211, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641071, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641073, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 36833; Mature: 36833

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEEKLMFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIID
CCCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCEEEECEEEEEEEEECCHHHHHHH
ETIAEQLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKAYEYEFVTSLKEDTP
HHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCEEEHHHHHHHHHCCCC
EFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELENAGADATKVGIGPG
CEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCC
KVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSL
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHH
FAGHIESPGKTVEVNGETFKEYYGSASAYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQD
HHHHCCCCCCEEEECCHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
LQSSISYAGGKDLDSLRHVDYVIVKNSIWNGDSI
HHHHHHCCCCCCHHHHHHCEEEEEECCCCCCCCC
>Mature Secondary Structure
MLKEEKLMFNDIPVFDYEDIQLIPNKCIITSRSQADTSVTLGKYQFKLPVIPANMQTIID
CCCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCEEEECEEEEEEEEECCHHHHHHH
ETIAEQLAKEGYFYIMHRFDEDSRKPFIKRMHEQGLIASISVGVKAYEYEFVTSLKEDTP
HHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCEEEHHHHHHHHHCCCC
EFITIDIAHGHANSVIDMIKHIKTELPETFVIAGNVGTPEAVRELENAGADATKVGIGPG
CEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCC
KVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSL
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCHHHHHHHHH
FAGHIESPGKTVEVNGETFKEYYGSASAYQKGEHKNVEGKKILLPTKGHLSDTLTEMQQD
HHHHCCCCCCEEEECCHHHHHHCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
LQSSISYAGGKDLDSLRHVDYVIVKNSIWNGDSI
HHHHHHCCCCCCHHHHHHCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11917108 [H]