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The map label for this gene is malP [H]

Identifier: 94994379

GI number: 94994379

Start: 931848

End: 933179

Strand: Direct

Name: malP [H]

Synonym: MGAS10750_Spy0983

Alternate gene names: 94994379

Gene position: 931848-933179 (Clockwise)

Preceding gene: 94994376

Following gene: 94994380

Centisome position: 48.11

GC content: 42.04

Gene sequence:

>1332_bases
ATGGAAACAATAAGCAAGAAAATGCCTCAAAAAGACTTGTCTGAGCATTCAAAAGCATGGCAAAATAGGCGAATAGGCTC
CGTTCCCTTGCCTGTTTATTTGGTTTTAGCTACCTTAATTTTAGTCACAGGCTGGCTCCAACAGTTGCCTGTTAATATGC
TGGGTGGCTTTGCTGTTATTTTAACCCTTGGTTGGCTACTAGGAACCATTGGAGCGACCATTCCAGGCCTCAAACATTTT
GGTGGCCCAGCTATTTTATCACTCTTAGTCCCTTCGATTTTGGTTTTTTTTAATCTCCTCAACCCCAATGTCTTACAAGC
GACGAATGTCTTGATGAAGCAAGCCAATTTTCTTTATTTTTATATTGCCTGCCTGGTCTGCGGTAGTATTTTAGGCATGA
ATCGAAAAATCTTGATCCAAGGTCTTTTTCGGATGATTATTCCCATGTTACTTGGAATGGTTTGTGCAATGGGTGTAGGG
ACTTTGGTTGGCGTCATTTTAGGATTAGACTGGCAACATACCCTCTTTTATGTTGTGACACCAGTCCTTGCTGGAGGAAT
TGGTGAAGGTATTTTACCCTTATCTCTTGGTTACAGTGCCATTACAGGAGTCGGAAGTGAGCAATTAGTGGCTCAACTGA
TTCCAGCCACCATTATTGGGAATTTCTTTGCTATCTTGTGCACGGCTTTGCTCAATCGTTTTGGAGAGAAGCATCCAAGT
TATTCTGGTCAAGGGCAACTGGTTAAAATTGGTCACAGCGAAGACATGTCTGATGCCCTAAAAGACAATTCTGGAGCCCT
AGATGTTAAATTAATGGGGGCAAGCGTTTTAACAGCTTGTTCACTTTTTATTGCTGGTGGCTTGTTACAGCATTTAACAG
GTTTTCCAGGACCGGTGTTGATGATTATTCTGGCAGCCTTCTTGAAATACCTGAATGTTATTCCCCAAGAAACCCAAAAT
GGTGCCAAACAACTTTATAAATTTATTTCCAGCAACTTTACTTTTCCGTTAATGGCAGGGCTTGGTCTGCTTTATATCCC
CTTAAAAGAGGTTGTGGCAACCCTTAGCTGGCAATATTTTATTGTGGTGATTAGTGTGGTGTTAACGGTTGTCAGTGTCG
GTTTTTTTGTCTCTCGTTTCCTTAACATGAACCCAGTGGAAGCAGCTATTATTTCAGCTTGTCAAAGTGGTATGGGTGGA
ACAGGGGACGTGGCTATTTTGAGTACGGCTGACCGCATGAATCTAATGCCGTTTGCCCAAGTCGCTACTCGTCTAGGCGG
GGCCATTACCGTTATCACCATGACAGCTATTTTAAGAATTATTTTTAGTTAA

Upstream 100 bases:

>100_bases
AAATAACTTGAAAAAATTAAAGTAGTTAAACAACTTAAATAAACTATGCTTTTGACATGTTCTCTTTTATACTAGCCTTA
TCACTAAAGGAGGTTGTTTC

Downstream 100 bases:

>100_bases
TCCAAACCAATAAAAAGAGAGGTATTTCCTATGAAAAATCAATTAGGTCAACTTGCCCTTGAACAAGCTAAAACGTTCGG
AGGTAAATTGGAAGTTCAAC

Product: Malate-sodium symport

Products: NA

Alternate protein names: Sodium-dependent malate transporter [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
METISKKMPQKDLSEHSKAWQNRRIGSVPLPVYLVLATLILVTGWLQQLPVNMLGGFAVILTLGWLLGTIGATIPGLKHF
GGPAILSLLVPSILVFFNLLNPNVLQATNVLMKQANFLYFYIACLVCGSILGMNRKILIQGLFRMIIPMLLGMVCAMGVG
TLVGVILGLDWQHTLFYVVTPVLAGGIGEGILPLSLGYSAITGVGSEQLVAQLIPATIIGNFFAILCTALLNRFGEKHPS
YSGQGQLVKIGHSEDMSDALKDNSGALDVKLMGASVLTACSLFIAGGLLQHLTGFPGPVLMIILAAFLKYLNVIPQETQN
GAKQLYKFISSNFTFPLMAGLGLLYIPLKEVVATLSWQYFIVVISVVLTVVSVGFFVSRFLNMNPVEAAIISACQSGMGG
TGDVAILSTADRMNLMPFAQVATRLGGAITVITMTAILRIIFS

Sequences:

>Translated_443_residues
METISKKMPQKDLSEHSKAWQNRRIGSVPLPVYLVLATLILVTGWLQQLPVNMLGGFAVILTLGWLLGTIGATIPGLKHF
GGPAILSLLVPSILVFFNLLNPNVLQATNVLMKQANFLYFYIACLVCGSILGMNRKILIQGLFRMIIPMLLGMVCAMGVG
TLVGVILGLDWQHTLFYVVTPVLAGGIGEGILPLSLGYSAITGVGSEQLVAQLIPATIIGNFFAILCTALLNRFGEKHPS
YSGQGQLVKIGHSEDMSDALKDNSGALDVKLMGASVLTACSLFIAGGLLQHLTGFPGPVLMIILAAFLKYLNVIPQETQN
GAKQLYKFISSNFTFPLMAGLGLLYIPLKEVVATLSWQYFIVVISVVLTVVSVGFFVSRFLNMNPVEAAIISACQSGMGG
TGDVAILSTADRMNLMPFAQVATRLGGAITVITMTAILRIIFS
>Mature_443_residues
METISKKMPQKDLSEHSKAWQNRRIGSVPLPVYLVLATLILVTGWLQQLPVNMLGGFAVILTLGWLLGTIGATIPGLKHF
GGPAILSLLVPSILVFFNLLNPNVLQATNVLMKQANFLYFYIACLVCGSILGMNRKILIQGLFRMIIPMLLGMVCAMGVG
TLVGVILGLDWQHTLFYVVTPVLAGGIGEGILPLSLGYSAITGVGSEQLVAQLIPATIIGNFFAILCTALLNRFGEKHPS
YSGQGQLVKIGHSEDMSDALKDNSGALDVKLMGASVLTACSLFIAGGLLQHLTGFPGPVLMIILAAFLKYLNVIPQETQN
GAKQLYKFISSNFTFPLMAGLGLLYIPLKEVVATLSWQYFIVVISVVLTVVSVGFFVSRFLNMNPVEAAIISACQSGMGG
TGDVAILSTADRMNLMPFAQVATRLGGAITVITMTAILRIIFS

Specific function: Acts as a Na(+)-malate symporter, as it catalyzes malate-dependent uptake of Na(+) and Na(+)-dependent uptake of malate [H]

COG id: COG3493

COG function: function code C; Na+/citrate symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:citrate (SCF) symporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004679
- InterPro:   IPR018025 [H]

Pfam domain/function: PF03390 2HCT [H]

EC number: NA

Molecular weight: Translated: 47392; Mature: 47392

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10903309; 12949159 [H]