Click here to switch to the map view.

The map label for this gene is murB [H]

Identifier: 94994372

GI number: 94994372

Start: 924741

End: 925628

Strand: Direct

Name: murB [H]

Synonym: MGAS10750_Spy0976

Alternate gene names: 94994372

Gene position: 924741-925628 (Clockwise)

Preceding gene: 94994371

Following gene: 94994373

Centisome position: 47.74

GC content: 41.33

Gene sequence:

>888_bases
ATGATAACTGAACTTCATGGGATTGATATTCGAGAGAATGAACCCCTAAAACATTACACTTACACTAAGGTAGGTGGCCC
AGCAGATTTCTTGGCTTTTCCTAGAAATCACTACGAGCTATCACGCATCGTTGCTTATGCCAACAAAGAAAATATGCCTT
GGCTTGTTTTGGGAAATGCCAGCAATCTCATTGTGCGAGATGGTGGTATTCGTGGCTTTGTCATCATGTTTGATAAGCTA
AATGCAGTGCACTTAAATGGTTATACCTTAGAAGCCGAAGCTGGTGCCAATCTGATTGAAACAACGAAGATTGCCAAATT
CCATAGTTTAACAGGGTTTGAATTTGCATGTGGCATTCCTGGAAGCATTGGGGGTGCTGTTTTTATGAATGCAGGTGCCT
ATGGTGGGGAAATATCACATATTTTCTTATCCGCTAAGGTGCTTACCTCAAGTGGAGAGATCAAAACCATTTCAGCTAGG
GATATGGCTTTTGGTTACCGTCACTCTGCCATTCAAGAAACAGGTGACATTGTCATTTCTGCTAAGTTTGCTCTTAAACC
GGGTAATTATGATACGATCAGCCAAGAAATGAATCGGTTAAATCACCTTCGCCAACTAAAACAACCTTTAGAATTTCCAT
CTTGTGGATCTGTGTTTAAGCGCCCGCCAGGACACTTTGCAGGTCAATTAATCATGGAAGCAAATCTTAAAGGGCATCGG
ATTGGTGGTGTGGAAGTTTCCGAAAAACACGCTGGTTTTATGATTAATGTGGCAGATGGCACAGCTAAAGATTATGAAGA
TTTGATTGCTTATGTCATTGAGACAGTTGAAAACCATTCTGGTGTCAGGCTTGAACCAGAAGTTCGGATTATTGGGGAAA
ACCTGTAA

Upstream 100 bases:

>100_bases
CCAAATTCATCGTTATTTTTTCTAAAATTTGATATAATAGTATCGGCTTTATGCCGATTTTTTTACGTGTATAAGAAGTG
ATAAAAGAAAGAAGATAACT

Downstream 100 bases:

>100_bases
CCATTATTGATAATTAAAGAAAGTACCGTGGAGGATTTATGACAATTGACTAAGCCAATTATCACATTTAACAATGTTTC
AAAAACATTTGAGGACAGTG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKL
NAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISAR
DMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHR
IGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL

Sequences:

>Translated_295_residues
MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKL
NAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISAR
DMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHR
IGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
>Mature_295_residues
MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNASNLIVRDGGIRGFVIMFDKL
NAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISAR
DMAFGYRHSAIQETGDIVISAKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHR
IGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL

Specific function: Cell wall formation [H]

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C [H]

EC number: =1.1.1.158 [H]

Molecular weight: Translated: 32335; Mature: 32335

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNA
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHEECCCCCCCEEEECCC
SNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIP
CEEEEECCCCEEEEEEEECCCEEEECCEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCC
GSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISARDMAFGYRHSAIQETGDIVIS
CCCCCEEEEECCCCCCCEEEEEEEEEEEECCCCEEEEEHHHHHCCHHHHHHHCCCCEEEE
AKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHR
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHEEEEEEECCCCEE
IGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
ECCEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEECCC
>Mature Secondary Structure
MITELHGIDIRENEPLKHYTYTKVGGPADFLAFPRNHYELSRIVAYANKENMPWLVLGNA
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHEECCCCCCCEEEECCC
SNLIVRDGGIRGFVIMFDKLNAVHLNGYTLEAEAGANLIETTKIAKFHSLTGFEFACGIP
CEEEEECCCCEEEEEEEECCCEEEECCEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCC
GSIGGAVFMNAGAYGGEISHIFLSAKVLTSSGEIKTISARDMAFGYRHSAIQETGDIVIS
CCCCCEEEEECCCCCCCEEEEEEEEEEEECCCCEEEEEHHHHHCCHHHHHHHCCCCEEEE
AKFALKPGNYDTISQEMNRLNHLRQLKQPLEFPSCGSVFKRPPGHFAGQLIMEANLKGHR
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHEEEEEEECCCCEE
IGGVEVSEKHAGFMINVADGTAKDYEDLIAYVIETVENHSGVRLEPEVRIIGENL
ECCEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]