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The map label for this gene is hemN [H]

Identifier: 94994313

GI number: 94994313

Start: 871952

End: 873082

Strand: Direct

Name: hemN [H]

Synonym: MGAS10750_Spy0917

Alternate gene names: 94994313

Gene position: 871952-873082 (Clockwise)

Preceding gene: 94994312

Following gene: 94994314

Centisome position: 45.01

GC content: 38.73

Gene sequence:

>1131_bases
ATGTCAAAAAAACCTACTTCAGCCTATGTGCACATTCCTTTTTGCACACAAATTTGTTATTATTGCGATTTTTCAAAAGT
CTTTATCCAAAATCAACCTGTTGATGCTTATTTGAGAGCCTTGATTCAAGAATTTGACTCTTATGGCATTCGAGACCTAA
AAACCCTTTATATTGGAGGAGGTACGCCTACAGCTATCACTGCTAAACAGTTGGAGTATCTCCTAAATCACCTTGAACGA
AACCTCAATTTAGATGATCTTGAAGAATTCACAATTGAGGCAAATCCTGGTGATTTGACGCCAGAAAAAATTGCGGTGCT
TCAGAGGTCAGCTGTCAATCGGATTTCCTTGGGGGTGCAGACTTTTAATAACAAGCAATTAAAGCAGATTGGCCGTAGCC
ATAATGAAGAACAAATTTATAGCACCATCGCTAATTTAAAAGCTGCAGGCTTTCACAATATTTCCATTGATTTAATTTAT
GCCTTGCCAGGTCAAACCTTAGATCAAGTCAAGGAAAATGTTGCTAAAGCTTTGGCACTTGATATTCCCCACCTTAGTCT
TTATAGCCTTATTTTGGAACATCACACTGTTTTTATGAACAAAATGCGGCGTGGTAAACTTAACTTACCAACGGAAGACT
TGGAAGCAGAAATGTTTGAGTATATTATTTCAGAAATGGAAGCTAATGGCTTTGAACATTATGAAATCTCTAATTTTACC
AAACCAGGTTTTGAAAGTCGCCATAACTTGATGTATTGGGATAATGTGGAGTATTTTGGATGTGGTGCAGGGGCTTCAGG
TTACCTTAATGGCATTCGTTATCAAAATCGGGTGCCCATCCAGCATTATCTTAAAGCGGTTGAAGCAGGGAATGCTAGAC
TAAATGAAGAAGTGCTGCGCAAAGAGGAAATGATGGAAGAGGAACTCTTTTTGGGCTTACGTAAAAAGACAGGAGTCTCC
ATCCAGCGGTTCCAAGAAAAATTTGGTATGCCTTTTGAGGAGCGTTATGGAAATATTGTTAGGGAGCTTCAAAACCAAGG
ACTGCTTGTCAAAGATGACGCCTTTGTCAGAATGACTAAAAAGGGTCTTTTCTTAGGTGATTCTGTTGCTGAGCGGTTTA
TATTAGATTAG

Upstream 100 bases:

>100_bases
ACGTTTGTCAGCTCGTAAAATACTTTTCCAAGCCATGAAGAATCAAGGGAAATGGTTTATTCATAAAAACATTTTATCAC
CAAAGTGATATAATAAGACC

Downstream 100 bases:

>100_bases
GAGAGTATTATGGGATTAAGTTATCAGGAGGAGTTGACACTTCCTTTTGAATTATGTGATGTCAAATCAGATATAAAATT
GCCCCTTTTATTAGACTATT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLRALIQEFDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLER
NLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKAAGFHNISIDLIY
ALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEMFEYIISEMEANGFEHYEISNFT
KPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVS
IQRFQEKFGMPFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD

Sequences:

>Translated_376_residues
MSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLRALIQEFDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLER
NLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKAAGFHNISIDLIY
ALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEMFEYIISEMEANGFEHYEISNFT
KPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVS
IQRFQEKFGMPFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD
>Mature_375_residues
SKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLRALIQEFDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLERN
LNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKAAGFHNISIDLIYA
LPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEMFEYIISEMEANGFEHYEISNFTK
PGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVSI
QRFQEKFGMPFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=263, Percent_Identity=31.5589353612167, Blast_Score=158, Evalue=8e-39,
Organism=Escherichia coli, GI1789325, Length=268, Percent_Identity=36.1940298507463, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI87082341, Length=384, Percent_Identity=25, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43120; Mature: 42989

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLRALIQEFDSYGIRDLKTLYIGG
CCCCCCCCEEECHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECC
GTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQ
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TFNNKQLKQIGRSHNEEQIYSTIANLKAAGFHNISIDLIYALPGQTLDQVKENVAKALAL
HCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
DIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEMFEYIISEMEANGFEHYEISNFT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
KPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEVLR
CCCCCCCCCEEEECCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
KEEMMEEELFLGLRKKTGVSIQRFQEKFGMPFEERYGNIVRELQNQGLLVKDDAFVRMTK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCHHEEEHH
KGLFLGDSVAERFILD
CCCEECHHHHHHHCCC
>Mature Secondary Structure 
SKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLRALIQEFDSYGIRDLKTLYIGG
CCCCCCCEEECHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECC
GTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQ
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TFNNKQLKQIGRSHNEEQIYSTIANLKAAGFHNISIDLIYALPGQTLDQVKENVAKALAL
HCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
DIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEMFEYIISEMEANGFEHYEISNFT
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCC
KPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEVLR
CCCCCCCCCEEEECCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
KEEMMEEELFLGLRKKTGVSIQRFQEKFGMPFEERYGNIVRELQNQGLLVKDDAFVRMTK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCHHEEEHH
KGLFLGDSVAERFILD
CCCEECHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]