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The map label for this gene is cpsFO [H]

Identifier: 94994224

GI number: 94994224

Start: 801328

End: 802197

Strand: Direct

Name: cpsFO [H]

Synonym: MGAS10750_Spy0828

Alternate gene names: 94994224

Gene position: 801328-802197 (Clockwise)

Preceding gene: 94994223

Following gene: 94994225

Centisome position: 41.37

GC content: 42.07

Gene sequence:

>870_bases
ATGAAAGGTATTATTCTTGCAGGAGGTTCAGGGACACGCTTGTATCCACTGACCCGTGCCGCATCTAAACAGTTGATGCC
CATTTATGACAAACCAATGATTTATTACCCATTGTCAACCTTGATGTTGGCAGGGATTAAAGATATTTTAATCATTTCAA
CTCCCCAAGATCTTCCTCGTTTCGAAGAATTGCTAGGAGACGGGTCAGAATTTGGCATTAGCTTATCCTATAAGGAACAA
CCAAGCCCAGATGGTTTAGCACAAGCTTTCATTATTGGAGAGGAGTTTATCGGTGATGACCGTGTTGCTCTTATTTTAGG
AGATAATATTTACCACGGTAATGGCCTCACTAAAATGCTTCAAAAGGCAGCTGCCAAAGAAAAAGGAGCCACCGTTTTTG
GTTATCAAGTGAAAGACCCTGAGCGCTTTGGAGTGGTGGAATTTGATGAGAACATGAATGCTATCTCTATCGAAGAAAAA
CCAGAAGTGCCTAAGTCCCACTTTGCAGTGACTGGACTTTATTTCTATGACAATGACGTGGTAGAGATTGCTAAAAACAT
TAAACCAAGCGCGCGTGGTGAGTTGGAAATTACAGACGTCAACAAGGCTTACTTGGAACGTGGTGACCTCTCCGTTGAAT
TGATGGGGCGTGGTTTTGCATGGCTAGACACTGGAACGCATGAAAGTCTACTTGAAGCGGCTCAATATATTGAAACAGTT
CAGCGCTTGCAAAACGCTCAAGTGGCAAATCTGGAAGAAATTGCCTATCGCATGGGTTATATCAGTAAAGAAGATGTCCA
TAAATTGGCGCAATCTTTAAAGAAAAACGAATACGGGCAATACTTGCTTCGTTTGATTGGAGAAGCTTAA

Upstream 100 bases:

>100_bases
TTCCCCTGAGCCTTACCTTTTGCGGTCTACTGGTAAAGCGTGACACTGCTTTCAAAAAATGATAGAATGATAGGGTATAT
AGAAGAATAGGAGCACTACT

Downstream 100 bases:

>100_bases
TGACAGAAACTTTTTTTGACAAACCATTGGCTTGCCGAGAAATCAAAGAAATCCCAGGCTTACTAGAGTTTGATATTCCT
GTTCGTGGGGATAATCGTGG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFEELLGDGSEFGISLSYKEQ
PSPDGLAQAFIIGEEFIGDDRVALILGDNIYHGNGLTKMLQKAAAKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
PEVPKSHFAVTGLYFYDNDVVEIAKNIKPSARGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRLQNAQVANLEEIAYRMGYISKEDVHKLAQSLKKNEYGQYLLRLIGEA

Sequences:

>Translated_289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFEELLGDGSEFGISLSYKEQ
PSPDGLAQAFIIGEEFIGDDRVALILGDNIYHGNGLTKMLQKAAAKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
PEVPKSHFAVTGLYFYDNDVVEIAKNIKPSARGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRLQNAQVANLEEIAYRMGYISKEDVHKLAQSLKKNEYGQYLLRLIGEA
>Mature_289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFEELLGDGSEFGISLSYKEQ
PSPDGLAQAFIIGEEFIGDDRVALILGDNIYHGNGLTKMLQKAAAKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEK
PEVPKSHFAVTGLYFYDNDVVEIAKNIKPSARGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRLQNAQVANLEEIAYRMGYISKEDVHKLAQSLKKNEYGQYLLRLIGEA

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=258, Percent_Identity=22.8682170542636, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=69.7916666666667, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=67.1328671328671, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788355, Length=237, Percent_Identity=22.7848101265823, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=237, Percent_Identity=24.0506329113924, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=254, Percent_Identity=25.5905511811024, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=23.4126984126984, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=23.4126984126984, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32137; Mature: 32137

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPQDLPR
CCCEEEECCCCCEEEEEHHHHCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FEELLGDGSEFGISLSYKEQPSPDGLAQAFIIGEEFIGDDRVALILGDNIYHGNGLTKML
HHHHHCCCCHHCEEEEECCCCCCCHHHHEEEEHHHHCCCCEEEEEEECCEEECCCHHHHH
QKAAAKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEKPEVPKSHFAVTGLYFYDNDV
HHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKNIKPSARGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
HHHHHCCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QRLQNAQVANLEEIAYRMGYISKEDVHKLAQSLKKNEYGQYLLRLIGEA
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPQDLPR
CCCEEEECCCCCEEEEEHHHHCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FEELLGDGSEFGISLSYKEQPSPDGLAQAFIIGEEFIGDDRVALILGDNIYHGNGLTKML
HHHHHCCCCHHCEEEEECCCCCCCHHHHEEEEHHHHCCCCEEEEEEECCEEECCCHHHHH
QKAAAKEKGATVFGYQVKDPERFGVVEFDENMNAISIEEKPEVPKSHFAVTGLYFYDNDV
HHHHHHHCCCEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCHH
VEIAKNIKPSARGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
HHHHHCCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QRLQNAQVANLEEIAYRMGYISKEDVHKLAQSLKKNEYGQYLLRLIGEA
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]