Click here to switch to the map view.

The map label for this gene is capA [H]

Identifier: 94994116

GI number: 94994116

Start: 696192

End: 697484

Strand: Direct

Name: capA [H]

Synonym: MGAS10750_Spy0720

Alternate gene names: 94994116

Gene position: 696192-697484 (Clockwise)

Preceding gene: 94994115

Following gene: 94994118

Centisome position: 35.94

GC content: 37.2

Gene sequence:

>1293_bases
ATGATACTATTGAAAAGCCTCTATAAGGGCTTTTTTGCTGCAATGAAGGAGGAAAATTTTGAGGCAAGATGTTATAATAG
AGAAAAAGGAGGGTGTGTCTTGATTAAAACTATGCAATACAAAAAAACGATGGCAACAGTTGTTGCTCTTATCGTCGCAC
TTTTGCTATTTGGCTTGATTTATGATTTACTTGGGGTTCAAAAAAATGAGCTAGCAGCTCAAAAATCTGCTCAGCCAAAG
GTCAAAGCAGCGCGTGTTGTAGCTAATGGCGACATTTTAATTCATGATATTCTCTACATGAGTGCTAGAAAAGCTGACGA
TACCTATGATTTCACTCCTTATTTTGAATATGTTAAGGACTGGATTAGCGGTGCTGACTTAGCTATTGGAGATTATGAAG
GGACCATTAGCCCAGATTATCCCTTAGCAGGCTATCCCTTATTCAATGCTCCAGAAGAGATTGCAGGTGCTCTGAAAAAT
ACTGGCTATGATGTAGTCGATTTAGCCCATAATCATATCTTAGATTCCCAATTAGACGGTGCCCTTAACACTAAAAAGGT
TTTTCATCAATTAGGTATAGACAGTATTGGCATCTATGACAAGGATCGTTCAAAAGAATCCTTCTTAATTAAAAATGTCA
ATGGTATCAAAATTGCAATTTTAGGTTATTCTTATGGTTATAACGGCATGGAGGCCACACTTAGCCAAGAAGACTATGAG
AAACACATGTCTGATTTAGATGAAGCTAAGATAAAAAAAGAACTTCAGCTAGCTGAAAAAAAGGCTGACGTGACCATTGT
CATGCCACAAATGGGAACAGAATATGCCTTAGAACCGACAGCAGAGCAAAAAGAACTTTACCACAAAATGATTGATTGGG
GAGCTGACGTCGTCCTAGGAGGCCATCCGCATGTTATTGAACCTTCAGAGACAGTTATAAAAGGTAGGCAAAAGAAATTC
ATTATTTACTCTATGGGAAATTTTATTTCAAATCAGCGGCTTGAAACCGTAGATGATATCTGGACTGAGCGTGGCCTATT
GATGGACCTTACTTTTGAGAAAAAAGATAACAAAACAAAAATTAAAACAGTTGAGGCCCATCCAACCATGGTTTTAGCCA
AAGGTAAAGGTATTGTGGGTAAAGAAGGTTTTGAACTATACAATTATCGAACAATGGTTTTAGAAGATTTTATCAAAGGT
GGAAAATACCACGACAAGATTGATGAGGAAACCAAAGCAAAAGTAGCACTTGCTTATCAGGAAATTAATGATTTAGTTAA
CCTGAAATGGTAA

Upstream 100 bases:

>100_bases
ACAGAAATCACACCTGAAATCGTCAATGATGAGGTTGAAAATCTCATTGATGCTTTACTTTAAAAGAAAAGATCAAGTGT
AAATCTTTTAGTAGTCAGTA

Downstream 100 bases:

>100_bases
TGTTTGGTGGTTTAGCATCTAATGGCCAAATTTCAAGTTGAAGTTAGCCAGTTTTAACATTTCTACTGGCGACTTGTAGT
TGAAGAGTCGTTTAGGATAA

Product: Capsule biosynthesis protein capA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPK
VKAARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKF
IIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKG
GKYHDKIDEETKAKVALAYQEINDLVNLKW

Sequences:

>Translated_430_residues
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPK
VKAARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKF
IIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKG
GKYHDKIDEETKAKVALAYQEINDLVNLKW
>Mature_430_residues
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPK
VKAARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKF
IIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKG
GKYHDKIDEETKAKVALAYQEINDLVNLKW

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 48508; Mature: 48508

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLI
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
YDLLGVQKNELAAQKSAQPKVKAARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKD
HHHHCCCHHHHHHHHCCCCCHHEEEEEECCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHH
WISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKNTGYDVVDLAHNHILDSQLDG
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
ALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
CCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHCCHHHHH
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLG
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEC
GHPHVIEPSETVIKGRQKKFIIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTK
CCCCEECCCHHHHCCCCCEEEEEECCCHHCCCCHHHHHHHHHCCCEEEEEEECCCCCCCE
IKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKGGKYHDKIDEETKAKVALAYQ
EEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EINDLVNLKW
HHHHHHCCCC
>Mature Secondary Structure
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLI
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
YDLLGVQKNELAAQKSAQPKVKAARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKD
HHHHCCCHHHHHHHHCCCCCHHEEEEEECCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHH
WISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKNTGYDVVDLAHNHILDSQLDG
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
ALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
CCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHCCHHHHH
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLG
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEC
GHPHVIEPSETVIKGRQKKFIIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTK
CCCCEECCCHHHHCCCCCEEEEEECCCHHCCCCHHHHHHHHHCCCEEEEEEECCCCCCCE
IKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKGGKYHDKIDEETKAKVALAYQ
EEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EINDLVNLKW
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]