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The map label for this gene is ezrA [H]

Identifier: 94994033

GI number: 94994033

Start: 604927

End: 606651

Strand: Direct

Name: ezrA [H]

Synonym: MGAS10750_Spy0637

Alternate gene names: 94994033

Gene position: 604927-606651 (Clockwise)

Preceding gene: 94994032

Following gene: 94994035

Centisome position: 31.23

GC content: 37.04

Gene sequence:

>1725_bases
ATGTCAAGCGGAATTATCTTGCTGATTGTGGCTATAGTCCTACTAGTGATTATCGCCTATCTAGTGGGTGTCATCATACG
AAAGCGTAATGATTCCCTAATTACCAGTCTAGAAGAACGAAAACAGGCCTTGTTTGCTTTGCCTGTTAATGATGAAATTG
AAGAAGTAAAGTCACTTCATTTGATAGGACAGAGCCAAACCTCTTTTCGGGAATGGAATCAGAAATGGGTAGACTTAACT
GTAAATTCGTTTGCAGATATTGAAAATCATATTTTTGAAGCTGAAAATTTGAATGATACGTTTAATTTTATTCGCGCCAA
GCATGAGATTAATAGCGTTGAAAGTCAGCTTAATCTTGTTGAAGAAGATATCGCTTCTATTCGTGAAGCACTTAATATCT
TAAAAGAGCAAGAAGAAAAAAATAGTGCTCGTGTCACCCATGCTCTTGATTTATATGAAAAGCTCCAAGCTTCTATTTCT
GAGAATGAAGATAATTTTGGTTCAACTATGCCTGAAATTGACAAACAGATGAAAAACATTGAAACTGAATTTTCACAGTT
TGTCGCACTCAACTCATCAGGTGATCCTGTAGAAGCTTCTGAAGTTCTGGATAGAGCAGAAGAGCATACTATTGCTCTAG
GGCAGATTACAGAGCAGATTCCAGCTATTGTCGCCAAGTTGGAAGATGATTTTCCAGATCAGTTAGATGATTTGGAAACA
GGATATCGCCGTTTACTTGAAGAAAACTATCATTTTCCAGAAAAAAACATTGAGGCACGTTTTCAGGAGATTCGTGAGTC
TATTCGTGCCAATTCATCAGAGTTAGTTACACTTGACTTGGATCGTGCTAGAGAAGAAAACACGCATATTCAAGAACGCA
TTGATTCTCTTTATGAAGTCTTTGAGCGCGAAATTGCCGCTTATAAGGTAGCTGCTAAAAATAGTAAGATGCTACCTCGT
TACCTAGCACATGTGAAACATAATAATGAACAACTCAAAGATGAAATTGCACGTTTATCACGTAAATATATTCTAAGTGA
AACGGAAAGTCTGACTGTTAAGGCATTTGAGAAGGATATTAAAGAGATCGAAGACAGTACACTTGCTGTTGCAGAACAAT
TTGGTTTACAAGAAAAACCATTTTCAGAACTGCAAGTGACTTTTGAACGCAGTATAAAGACGCTTACTAATGTCGAGTCA
GGTCAAATGGATGTTTTTGCAGCAGTTAAAGATATTGAAAAAATTGAATCACAGGCACGCCATAACCTTGATGTTTATGT
TACTCAGCTTCATATGATTAAACGTTATATGGAAAAACGTCACTTGCCTGGAATTCCACAAGACTTTCTTAGTGCTTTCT
TTACAACGAGTTCACAGTTGGAAGCTTTGATGGATGAGCTTAGTAGAGGACGGATCAATATTGAGGCAGTGTCACGTTTG
TCGGAAGTTGCGACGGTTGCTATTGCTAATCTAGAAGATTTAACCTATCAAGTGGTTCAAAATGCTACCTTGACTGAACA
ATTACTACAATATTCTAATCGCTATCGTTCTTTTGAAGCAGGAGTTCAAAGTAGTTTTGAACATGCTTTGAGACTTTTCG
AAGTAGAAAATGATTATCAGGCTTCTTTTGATGAAATTTCTTATGCTCTTGAAACAGTTGAACCCGGGGTAACAGATCGG
TTTGTTAACTCTTATGAAAAAACACGAGAGCACATTCGTTTTTGA

Upstream 100 bases:

>100_bases
TTTAAATAAAATTTTAATAAAAGGCGATTGAGGAATTTCAGTTTTTAGTTATTACTGGAACAATGTTGATAAATCGTGTC
TAAATAATAAGGAGATTCAG

Downstream 100 bases:

>100_bases
TACTTGAAAGTCGTGATATTCTCACGACTTTTTATTAGCTTTTTGGACCAATACGTGTTTTTGACTAGAATCTTCTTTTT
AATGATCAAACGAAGAAGTA

Product: septation ring formation regulator EzrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLT
VNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASIS
ENEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPR
YLAHVKHNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVES
GQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDR
FVNSYEKTREHIRF

Sequences:

>Translated_574_residues
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLT
VNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASIS
ENEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPR
YLAHVKHNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVES
GQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDR
FVNSYEKTREHIRF
>Mature_573_residues
SSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLTV
NSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISE
NEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLETG
YRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPRY
LAHVKHNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESG
QMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRLS
EVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDRF
VNSYEKTREHIRF

Specific function: Negative regulator of ftsZ ring formation; modulates the frequency and position of ftsZ ring formation. Inhibits ftsZ ring formation at polar sites. Interacts either with ftsZ or with one of its binding partners to promote depolymerization [H]

COG id: COG4477

COG function: function code D; Negative regulator of septation ring formation

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein. Note=Colocalized with ftsZ to the nascent septal site [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ezrA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010379 [H]

Pfam domain/function: PF06160 EzrA [H]

EC number: NA

Molecular weight: Translated: 66044; Mature: 65913

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLH
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHH
LIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISENEDNFGSTMPEIDKQMKNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
HHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHH
FEREIAAYKVAAKNSKMLPRYLAHVKHNNEQLKDEIARLSRKYILSETESLTVKAFEKDI
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESGQMDVFAAVKDIEKIESQAR
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
HNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ASFDEISYALETVEPGVTDRFVNSYEKTREHIRF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLH
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHH
LIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISENEDNFGSTMPEIDKQMKNI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLET
HHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHH
FEREIAAYKVAAKNSKMLPRYLAHVKHNNEQLKDEIARLSRKYILSETESLTVKAFEKDI
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESGQMDVFAAVKDIEKIESQAR
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
HNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRL
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
SEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ASFDEISYALETVEPGVTDRFVNSYEKTREHIRF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]