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The map label for this gene is tpiA [H]

Identifier: 94993924

GI number: 94993924

Start: 510012

End: 510770

Strand: Direct

Name: tpiA [H]

Synonym: MGAS10750_Spy0528

Alternate gene names: 94993924

Gene position: 510012-510770 (Clockwise)

Preceding gene: 162139188

Following gene: 94993930

Centisome position: 26.33

GC content: 42.03

Gene sequence:

>759_bases
ATGTTACGTAAACCAATTATTGCTGGTAACTGGAAAATGAACAAAAACCCTCAAGAAGCAAAAGCATTCGTTGAGGCTGT
AGCAAGCAAATTACCTTCAACTGACCTTGTTGATGTTGCCGTAGCAGCCCCAGCTGTTGATTTGGTAACCACTATTGAAG
CTGCTAAAGATTCAGTTCTTAAAGTTGCTGCACAAAACTGCTACTTTGAAAACACAGGGGCATTCACTGGTGAAACATCA
CCAAAAGTGCTTGCTGAAATGGGAGCTGACTATGTTGTGATTGGTCACTCAGAACGCCGTGATTACTTCCATGAAACAGA
TGAAGACATTAATAAAAAAGCCAAAGCAATCTTTGCTAACGGTTTAACTCCAATTGTTTGTTGTGGTGAGTCTCTTGAAA
CTTATGAAGCTGGTAAAGCCGTTGAGTTTGTAGGTGCGCAAGTTTCAGCAGCACTTGCAGGTCTTTCAGCAGAGCAAGTA
GCTTCACTTGTTTTAGCTTATGAGCCAATCTGGGCTATTGGTACTGGTAAATCAGCTACTCAAGATGATGCTCAAAACAT
GTGTAAAGCTGTTCGTGACGTGGTAGCAGCAGACTTTGGGCAAGAAGTTGCTGATAAAGTTCGCGTTCAATACGGTGGTT
CTGTAAAACCTGAAAACGTTAAAGATTACATGGCTTGTCCAGATGTTGACGGTGCCCTTGTAGGTGGTGCATCACTTGAA
GCTGATAGCTTCCTTGCTTTGCTTGATTTCCTTAACTAA

Upstream 100 bases:

>100_bases
TATTTGTGAAAATATTCCTAAAATATAAGCAATTCCTTTTAATCGTCGGTCATTTGTGCTAAAATAGAAGATATAAATAA
AAAAAGAAGAGGTATGTGAT

Downstream 100 bases:

>100_bases
GTCATCTAAAAAAGAAAAGGTTAAATCCTTTTCTTTTTTAGATGACTTAACTCTTACTATGAGAGAATAAAGGTGATTCT
ACAGGCAAATGCATTAGCCT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETS
PKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQV
ASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
ADSFLALLDFLN

Sequences:

>Translated_252_residues
MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETS
PKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQV
ASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
ADSFLALLDFLN
>Mature_252_residues
MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETS
PKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQV
ASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
ADSFLALLDFLN

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=251, Percent_Identity=40.6374501992032, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI4507645, Length=251, Percent_Identity=40.6374501992032, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI1790353, Length=247, Percent_Identity=42.914979757085, Blast_Score=197, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=40.8, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6320255, Length=253, Percent_Identity=39.1304347826087, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572008, Length=257, Percent_Identity=40.8560311284047, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28572006, Length=257, Percent_Identity=40.8560311284047, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI28572004, Length=257, Percent_Identity=40.8560311284047, Blast_Score=177, Evalue=4e-45,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26644; Mature: 26644

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVL
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
KVAAQNCYFENTGAFTGETSPKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFAN
HHHHHHCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHC
GLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQVASLVLAYEPIWAIGTGKSAT
CCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCC
QDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEECCCCCC
ADSFLALLDFLN
HHHHHHHHHHCC
>Mature Secondary Structure
MLRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVL
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
KVAAQNCYFENTGAFTGETSPKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFAN
HHHHHHCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHC
GLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQVASLVLAYEPIWAIGTGKSAT
CCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCC
QDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEECCCCCC
ADSFLALLDFLN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA