Click here to switch to the map view.

The map label for this gene is hasB [H]

Identifier: 94993865

GI number: 94993865

Start: 459325

End: 460482

Strand: Direct

Name: hasB [H]

Synonym: MGAS10750_Spy0469

Alternate gene names: 94993865

Gene position: 459325-460482 (Clockwise)

Preceding gene: 94993864

Following gene: 94993866

Centisome position: 23.71

GC content: 30.05

Gene sequence:

>1158_bases
ATGAAAATTACAGTTGTAGGCATTGGATACGTTGGATTATCGATAGGGCTCCTACTTGCAAAGGAACACGACGTTACCTT
TTTTGATATTGATAATAAAAAAATTGATTTAATAAATAAAAGGCAATCCTCTCTTAAAGAAGCAGCTATAAACAAACTTT
TATGTAAGGCAAAAAATATTAATGCAACTTCTTCTGAAGAATTAGCATATAAGGATGCGACTTTCATAATCTTGTCTTTG
CCAACCAACCTAAAAGTTAATAAGCTTGATACTTCCATTATCGAAATTTCTGTAAGTAATATTTTAAAGATAAACAAAAA
GGCTACAATTGTAATAAAGTCGACAGTTCCAATTGGTTTTACAGAATATTTAAGGAATCGATTTCACTACAACGATATCA
TTTTTTCACCTGAGTTCCTTAGGGAAGGATCAACTATTCATGATCAATTGTATCCTTCGAGAACTATAGTTGGAAATGAA
TCTAGAAATTCTCAATTATTCTTAGACATACTAACAGATATATCGGTTGAAAAAGACTCGCCATCTTTATTAGTTGGCTC
TTCTGAAGCAGAAGCGATAAAGTTATTTTCGAATGCATACTTAGCACAAAAAATTGCTTTTTTTAATGAGTTGGATACGT
TTGCTGAAATGCAAAATTTGGACTCAAAAAAAATTATTGAGGCTATGGGATATGACCAGAGAATAGGAAATTCGCACAAT
AATCCTTCTTTCGGTTTTGGTGGGTACTGTCTTCCTAAGGATATTAAGCAATTAGAGTATCATTTTAAAGAAATTCCAGC
ACCAATTATTACCAGTATAAGTGAGTCTAATTTATTAAGAAAAATTCATATAGCAAAAATGATTTTGAACAGCTCAGCTA
AAACAATAGGAATTTATAGAATTAATTCCAAAAAAGATTCGGATAATTGTAGGGAATCTTCTACAATTGATGTTGCTAAA
CTTTTAAAAAGCAGTGGTAAGGATGTTATCATCTTTGAGCCATTAATTAATCAAAAAAAGTTTTTGGGGTGCCCTTTAAT
TAATGATTTTAATGAATTTATTAAATATTCGGATATTATAGTTGCCAATAGAATAGATGATGCTCTGAGAAAATGTAATT
CAAAAGTTTTTACACGTGATATTTTTCAGTATGATTAA

Upstream 100 bases:

>100_bases
ATCCAAAAATTTATATCATCTCATTTAGGTATAAAAATCAATTTTATATTCTTTCTAACAAAAAAATTGATTTATAAAAA
GTTTTAGAATAGAGGTTAAC

Downstream 100 bases:

>100_bases
CAAAAACATTTTTGCGAAAAAATATTTTTAAGTAATAAATTCAGTTAAAAGTTATTATATCTGAAAATTTTAAAGGTCTT
TAAAATGAACAATAGGAAAA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSSLKEAAINKLLCKAKNINATSSEELAYKDATFIILSL
PTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD

Sequences:

>Translated_385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSSLKEAAINKLLCKAKNINATSSEELAYKDATFIILSL
PTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD
>Mature_385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSSLKEAAINKLLCKAKNINATSSEELAYKDATFIILSL
PTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD

Specific function: Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis. Directly responsible for the transformation of some unencapsulated serotype-3 SP mutants to the encapsulated phenotype [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=373, Percent_Identity=28.686327077748, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI296040438, Length=274, Percent_Identity=30.2919708029197, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI296040443, Length=359, Percent_Identity=25.0696378830084, Blast_Score=105, Evalue=8e-23,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=43.298969072165, Blast_Score=340, Evalue=7e-95,
Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=22.6600985221675, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=376, Percent_Identity=27.9255319148936, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136908, Length=414, Percent_Identity=29.2270531400966, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43387; Mature: 43387

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSSLKEAAINKLLCKAKNI
CEEEEEEECHHHHHHEEEEEECCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
NATSSEELAYKDATFIILSLPTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGF
CCCCCCCEEECCEEEEEEECCCCCEEECCCCEEEEEEHHHHEEECCCEEEEEEECCCCCH
TEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNESRNSQLFLDILTDISVEKDS
HHHHHHHCCCCCEEECHHHHHCCCCHHHHHCCCCEEECCCCCCCEEEEEEHHCCEECCCC
PSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCC
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYR
CCCCCCCCEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEE
INSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDII
ECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHCEE
VANRIDDALRKCNSKVFTRDIFQYD
EEHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSSLKEAAINKLLCKAKNI
CEEEEEEECHHHHHHEEEEEECCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHCCCC
NATSSEELAYKDATFIILSLPTNLKVNKLDTSIIEISVSNILKINKKATIVIKSTVPIGF
CCCCCCCEEECCEEEEEEECCCCCEEECCCCEEEEEEHHHHEEECCCEEEEEEECCCCCH
TEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNESRNSQLFLDILTDISVEKDS
HHHHHHHCCCCCEEECHHHHHCCCCHHHHHCCCCEEECCCCCCCEEEEEEHHCCEECCCC
PSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCC
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYR
CCCCCCCCEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEE
INSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDII
ECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHCEE
VANRIDDALRKCNSKVFTRDIFQYD
EEHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929009; 8566758; 7869055 [H]