Click here to switch to the map view.

The map label for this gene is dhaK [H]

Identifier: 94993843

GI number: 94993843

Start: 436131

End: 437120

Strand: Direct

Name: dhaK [H]

Synonym: MGAS10750_Spy0447

Alternate gene names: 94993843

Gene position: 436131-437120 (Clockwise)

Preceding gene: 94993840

Following gene: 94993844

Centisome position: 22.51

GC content: 41.52

Gene sequence:

>990_bases
ATGAAAAAAATTATGAATGATGCCACTCAGATTGTGGACGATATGTTGCAAGGTTTAGCTTATATGCATGATGACTTAGT
GGAACGCCTAGATGGTTATGATGTGATTGTTCGTAAAGCAGAGAAGACGGGAAAAGTAGCCCTTATTTCAGGTGGTGGTT
CTGGACATGAGCCATCTCATGCTGGTTTTGTTGGTGAAGGCATGTTGTCAGCAGCTATCTGCGGTGCAGTCTTTACTTCC
CCAACTCCAGATCAAATTTTAGAAGCTATCAAAGCAGCTGATGAAGGTGCTGGTGTCTTTATGGTCATCAAAAATTATTC
AGGTGACATTATGAACTTTGAAATGGCCCAAGAATTAGCAGAAATGGAAGGTATTGATGTTGCCAGTGTTGTCGTTGATG
ATGATATTGCGGTTGAGAATAGCCTCTACACTCAAGGACGCCGTGGGGTTGCGGGAACCATTCTTGTTCACAAGATTTTG
GGACATGCTGCGCGTGAGGGCAAATCATTAGCAGATATTAAAGCTCTTGCTGATGAATTGGTCCTAAATATTAAAACTAT
CGGTTTAGCTCTTTCTGGAGCAACTGTTCCTGAAGTTGGCAAACCTGGTTTTGTGCTTGAAGATGATGAGTTTGAATACG
GTGTCGGTATTCACGGTGAACCAGGCTACAAAAAAGAAAAATTACAATCATCATCAGTATTAGCTCAAGAGTTGGTGACT
AAATTGGCAGATAGCTTTGACATGAGCGCAGGACCACATTATGGCGTCTTGGTCAATGGTTTGGGAGCTACACCATTAAT
GGAACAATACGTTTTTGCGAATGATGTGGCAAAACTCTTAGCAGAAAAAGATGTCACAGTCAGCTTCAAGAAAATTGGTG
ACTACATGACGTCTATTGATATGGCTGGTTTGTCTTTGACCTTGATCAAACTTGACAAGGATGAATGGACAGAAGCTCTT
CAATCAGATGTTATCACACCAGCTTGGTAA

Upstream 100 bases:

>100_bases
ATTTTAGAAAGAAAAGGGACAAATCTGAGGATTTGTCCCTTACGTTTTGGGAGGGGCTATTTTATAATGAAAGCGTAAAC
AAAAAATCGGAGGAAGATCC

Downstream 100 bases:

>100_bases
GGAGGAAATCATGCAAGCACAAGATGCAATCAAATGGATGACCTTATTTAATGATAAAATTCAAGTGAATAAGGATTATT
TAAGTCAATTGGATACGCCT

Product: dihydroxyacetone kinase subunit DhaK

Products: ADP; glycerone phosphate

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKKIMNDATQIVDDMLQGLAYMHDDLVERLDGYDVIVRKAEKTGKVALISGGGSGHEPSHAGFVGEGMLSAAICGAVFTS
PTPDQILEAIKAADEGAGVFMVIKNYSGDIMNFEMAQELAEMEGIDVASVVVDDDIAVENSLYTQGRRGVAGTILVHKIL
GHAAREGKSLADIKALADELVLNIKTIGLALSGATVPEVGKPGFVLEDDEFEYGVGIHGEPGYKKEKLQSSSVLAQELVT
KLADSFDMSAGPHYGVLVNGLGATPLMEQYVFANDVAKLLAEKDVTVSFKKIGDYMTSIDMAGLSLTLIKLDKDEWTEAL
QSDVITPAW

Sequences:

>Translated_329_residues
MKKIMNDATQIVDDMLQGLAYMHDDLVERLDGYDVIVRKAEKTGKVALISGGGSGHEPSHAGFVGEGMLSAAICGAVFTS
PTPDQILEAIKAADEGAGVFMVIKNYSGDIMNFEMAQELAEMEGIDVASVVVDDDIAVENSLYTQGRRGVAGTILVHKIL
GHAAREGKSLADIKALADELVLNIKTIGLALSGATVPEVGKPGFVLEDDEFEYGVGIHGEPGYKKEKLQSSSVLAQELVT
KLADSFDMSAGPHYGVLVNGLGATPLMEQYVFANDVAKLLAEKDVTVSFKKIGDYMTSIDMAGLSLTLIKLDKDEWTEAL
QSDVITPAW
>Mature_329_residues
MKKIMNDATQIVDDMLQGLAYMHDDLVERLDGYDVIVRKAEKTGKVALISGGGSGHEPSHAGFVGEGMLSAAICGAVFTS
PTPDQILEAIKAADEGAGVFMVIKNYSGDIMNFEMAQELAEMEGIDVASVVVDDDIAVENSLYTQGRRGVAGTILVHKIL
GHAAREGKSLADIKALADELVLNIKTIGLALSGATVPEVGKPGFVLEDDEFEYGVGIHGEPGYKKEKLQSSSVLAQELVT
KLADSFDMSAGPHYGVLVNGLGATPLMEQYVFANDVAKLLAEKDVTVSFKKIGDYMTSIDMAGLSLTLIKLDKDEWTEAL
QSDVITPAW

Specific function: Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone [H]

COG id: COG2376

COG function: function code G; Dihydroxyacetone kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DhaK domain [H]

Homologues:

Organism=Homo sapiens, GI20149621, Length=337, Percent_Identity=36.7952522255193, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI87081857, Length=352, Percent_Identity=43.75, Blast_Score=276, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17565018, Length=329, Percent_Identity=34.6504559270517, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321055, Length=319, Percent_Identity=38.5579937304075, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323570, Length=335, Percent_Identity=36.7164179104478, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004006
- InterPro:   IPR012736 [H]

Pfam domain/function: PF02733 Dak1 [H]

EC number: 2.7.1.29

Molecular weight: Translated: 35084; Mature: 35084

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIMNDATQIVDDMLQGLAYMHDDLVERLDGYDVIVRKAEKTGKVALISGGGSGHEPSH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEEECCCCCCCCCC
AGFVGEGMLSAAICGAVFTSPTPDQILEAIKAADEGAGVFMVIKNYSGDIMNFEMAQELA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECHHHHHHHH
EMEGIDVASVVVDDDIAVENSLYTQGRRGVAGTILVHKILGHAAREGKSLADIKALADEL
HHCCCCEEEEEECCCHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VLNIKTIGLALSGATVPEVGKPGFVLEDDEFEYGVGIHGEPGYKKEKLQSSSVLAQELVT
HHHHHHHEEEECCCCCCCCCCCCEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
KLADSFDMSAGPHYGVLVNGLGATPLMEQYVFANDVAKLLAEKDVTVSFKKIGDYMTSID
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
MAGLSLTLIKLDKDEWTEALQSDVITPAW
HCCCEEEEEEECHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKIMNDATQIVDDMLQGLAYMHDDLVERLDGYDVIVRKAEKTGKVALISGGGSGHEPSH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEEECCCCCCCCCC
AGFVGEGMLSAAICGAVFTSPTPDQILEAIKAADEGAGVFMVIKNYSGDIMNFEMAQELA
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECHHHHHHHH
EMEGIDVASVVVDDDIAVENSLYTQGRRGVAGTILVHKILGHAAREGKSLADIKALADEL
HHCCCCEEEEEECCCHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VLNIKTIGLALSGATVPEVGKPGFVLEDDEFEYGVGIHGEPGYKKEKLQSSSVLAQELVT
HHHHHHHEEEECCCCCCCCCCCCEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHH
KLADSFDMSAGPHYGVLVNGLGATPLMEQYVFANDVAKLLAEKDVTVSFKKIGDYMTSID
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
MAGLSLTLIKLDKDEWTEALQSDVITPAW
HCCCEEEEEEECHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; glycerone

Specific reaction: ATP + glycerone = ADP + glycerone phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]