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The map label for this gene is glmU [H]

Identifier: 94993760

GI number: 94993760

Start: 368082

End: 369464

Strand: Direct

Name: glmU [H]

Synonym: MGAS10750_Spy0364

Alternate gene names: 94993760

Gene position: 368082-369464 (Clockwise)

Preceding gene: 94993759

Following gene: 94993761

Centisome position: 19.0

GC content: 42.81

Gene sequence:

>1383_bases
ATGACAAATTATGCCATTATTTTAGCAGCGGGCAAAGGGACTCGCATGACTTCTGATCTCCCAAAAGTTCTTCATAAAGT
ATCTGGACTAACCATGCTTGAGCATGTTTTTCGTAGTGTAAAAGCGATTAATCCTGAAAAAGCCGTGACGGTTATTGGTC
ACAAATCAGAAATGGTACGTGCTGTCTTAGCAGATCAATCAGCCTTTGTCCATCAAACAGAGCAGTTAGGAACTGGCCAT
GCCGTGATGATGGCAGAAACACAACTAGAAGGACTAGAAGGGCATACCTTGGTGATTGCAGGAGATACTCCCTTGATCAC
TGGAGAAAGCCTGAAGAGTCTGATTGATTTTCATGTGAATCATAAAAATGTCGCCACTATTTTAACAGCTACGGCTCAAG
ATCCATTTGGTTATGGTCGTATTGTTCGCAACAAAGATGGCGAAGTGATCAAGATTGTTGAGCAAAAAGACGCCAATGAG
TATGAGCAACAATTAAAAGAAATCAATACAGGAACCTATGTGTTTGATAACAAGCGTCTCTTTGAAGCGCTCAAATGCAT
CACTACCAACAATGCTCAAGGAGAGTATTACCTGACTGATGTTGTGGCTATTTTTAGAGCAAACAAAGAAAAGGTAGGAG
CCTATATCCTGAGAGACTTCAATGAAAGTCTTGGTGTTAATGATCGTGTGGCCTTAGCAACAGCTGAAACAGTGATGCGT
CAGCGCATCACCCAAAAACATATGGTCAATGGGGTGACTTTCCAAAATCCTGAAACCGTTTATATTGAAAGCGATGTTGA
GATTGCTCCAGACGTCCTTATCGAAGGAAATGTGACCTTGAAAGGGCGTACACATATCGGCTCAGGAACTGTCTTGACGA
ATGGTACTTATATTGTGGATTCTGAAATTGGTGATAACTGTGTTGTTACTAATTCAATGATCGAATCATCTGTTTTAGCT
GCAGGAGTTACGGTTGGCCCTTACGCCCACCTTCGACCAGGAACGACCTTAGATAGGGAAGTCCATATCGGTAACTTTGT
TGAGGTCAAGGGTTCTCACATTGGTGAAAAAACAAAGGCTGGGCATCTGACTTATATTGGAAACGCTCAGGTTGGGTCTT
CAGTCAATGTTGGGGCTGGAACCATCACTGTCAACTACGACGGCCAAAACAAATATGAAACAGTCATTGGAGATCACGCT
TTTATTGGGAGCAACTCGACTCTCATTGCACCTTTGGAAGTTGGAGATAATGCTTTAACTGCAGCTGGCTCAACTATTTC
TAAGACAGTACCAGCTGATAGCATTGTTATTGGTGGTAGCCGCCAAGTCACAAAAGAAGGTTATGCCAAGCGCCTAGCGC
ATCACCCAAGTGGAAGCAAATAA

Upstream 100 bases:

>100_bases
GACACTATAAAAGACAAGAAAATGCTAGGATGTTTCAGGAAAAAAAGAGAAAATATGCTATAATGAGAAGGTATTTAAAT
TATATAGTAAGGAAGAACAA

Downstream 100 bases:

>100_bases
TTCAAGATCTATTTAGTAAGGAGGCCAGGCATGAAATTTGAAGAAAAAACGCTTAAGAGACAAACAGTTTTTGATGGTCA
TATTTTTAAAGTTGTTGTGG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGH
AVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANE
YEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR
QRITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLA
AGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVIGDHA
FIGSNSTLIAPLEVGDNALTAAGSTISKTVPADSIVIGGSRQVTKEGYAKRLAHHPSGSK

Sequences:

>Translated_460_residues
MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGH
AVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANE
YEQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR
QRITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLA
AGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVIGDHA
FIGSNSTLIAPLEVGDNALTAAGSTISKTVPADSIVIGGSRQVTKEGYAKRLAHHPSGSK
>Mature_459_residues
TNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVRAVLADQSAFVHQTEQLGTGHA
VMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVNHKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANEY
EQQLKEINTGTYVFDNKRLFEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMRQ
RITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVDSEIGDNCVVTNSMIESSVLAA
GVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKAGHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVIGDHAF
IGSNSTLIAPLEVGDNALTAAGSTISKTVPADSIVIGGSRQVTKEGYAKRLAHHPSGSK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=454, Percent_Identity=42.2907488986784, Blast_Score=345, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI133931050, Length=388, Percent_Identity=25.2577319587629, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21355443, Length=350, Percent_Identity=23.7142857142857, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=350, Percent_Identity=23.7142857142857, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49454; Mature: 49322

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVR
CCCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHH
AVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVN
HHHHCCHHHHHHHHHCCCCCEEEEEECHHCCCCCCEEEEECCCCEECHHHHHHHHHHHCC
HKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANEYEQQLKEINTGTYVFDNKRL
CCCEEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCHHH
FEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR
HHHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
QRITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVD
HHHHHHHHHCCEEECCCCEEEEECCCCCCCCEEEECCEEEEECEECCCCEEEECCEEEEE
SEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKA
CCCCCCEEEEHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEECCCEEEECCCCCCCCCCC
GHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVIGDHAFIGSNSTLIAPLEVGDNALT
CEEEEEECCCCCCCEECCCEEEEEEECCCCCEEEEECCEEEECCCCCEEEEEECCCCCEE
AAGSTISKTVPADSIVIGGSRQVTKEGYAKRLAHHPSGSK
ECCCCHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TNYAIILAAGKGTRMTSDLPKVLHKVSGLTMLEHVFRSVKAINPEKAVTVIGHKSEMVR
CCEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHH
AVLADQSAFVHQTEQLGTGHAVMMAETQLEGLEGHTLVIAGDTPLITGESLKSLIDFHVN
HHHHCCHHHHHHHHHCCCCCEEEEEECHHCCCCCCEEEEECCCCEECHHHHHHHHHHHCC
HKNVATILTATAQDPFGYGRIVRNKDGEVIKIVEQKDANEYEQQLKEINTGTYVFDNKRL
CCCEEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEEECCHHH
FEALKCITTNNAQGEYYLTDVVAIFRANKEKVGAYILRDFNESLGVNDRVALATAETVMR
HHHHHHHCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHH
QRITQKHMVNGVTFQNPETVYIESDVEIAPDVLIEGNVTLKGRTHIGSGTVLTNGTYIVD
HHHHHHHHHCCEEECCCCEEEEECCCCCCCCEEEECCEEEEECEECCCCEEEECCEEEEE
SEIGDNCVVTNSMIESSVLAAGVTVGPYAHLRPGTTLDREVHIGNFVEVKGSHIGEKTKA
CCCCCCEEEEHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEECCCEEEECCCCCCCCCCC
GHLTYIGNAQVGSSVNVGAGTITVNYDGQNKYETVIGDHAFIGSNSTLIAPLEVGDNALT
CEEEEEECCCCCCCEECCCEEEEEEECCCCCEEEEECCEEEECCCCCEEEEEECCCCCEE
AAGSTISKTVPADSIVIGGSRQVTKEGYAKRLAHHPSGSK
ECCCCHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]