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The map label for this gene is fabG [H]

Identifier: 94993757

GI number: 94993757

Start: 364506

End: 365204

Strand: Direct

Name: fabG [H]

Synonym: MGAS10750_Spy0361

Alternate gene names: 94993757

Gene position: 364506-365204 (Clockwise)

Preceding gene: 94993756

Following gene: 94993758

Centisome position: 18.82

GC content: 43.35

Gene sequence:

>699_bases
ATGACTAAAGTTGTTTTAGTGACGGGCTGTGCTAGTGGGATTGGTTATGCACAGGCCCGCTATTTTTTGAGCCAAGGGTA
TCACGTATATGGTGTGGATAAATCGGATAAACCGGACTTAAACGGTAATTTTCACTTTATCAAATTGGATTTATCCTCTG
AGTTATCCCCACTATTTAAAGTGGTCCCCAGTGTTGATATTTTGTGTAATACTGCGGGGATTTTAGATGCCTACAAACCA
CTTTTAGACGTCAGTGATGAAGAAGTGGAACACCTATTTGATATTAATTTTTTTGCGACGGTGAAGTTAACACGTCATTA
TCTTAGACATATGGTGGAAAAGCAGTCAGGTGTTATCATCAATATGTGCTCAATAGCAAGTTTTATAGCAGGTGGCGGTG
GTGTTGCCTATACGAGTTCTAAGCATGCGCTTGCGGGCTTCACGCGCCAGCTGGCTTTGGATTACGCCAAAGATCAGATT
CACATCTTTGGTATAGCACCAGGTGCTGTCAAAACCGCTATGACGGCTAGCGACTTTGAGCCTGGTGGCTTAGCAGACTG
GGTAGCTCGTGAGACGCCAATTGGGCGTTGGACTGAACCAAGTGAAGTTGCTGAATTAACGGGATTTCTTGCTTCAGGAA
AAACGAGATCAATGCAAGGTGAAATTGTCAAAATTGACGGTGGTTGGACTTTGAAATGA

Upstream 100 bases:

>100_bases
ACACCTTATTTTCTGATTCATGTTACTGGTGCAGGTGAAGGTTTTTCCATGTGGGCACCGACACCATGTGATGTGTTAGC
AGAAGATTGGATCGAGGTCA

Downstream 100 bases:

>100_bases
TCACATGCCTTAGCTTGAGCTGGCGCAGTAAGCCCTAGAGGTGTGATGAGTCAAACAGTCAAAGGAGATGAACAAATGAA
ATTAGCGGTTTTGGGGACAG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTKVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNFHFIKLDLSSELSPLFKVVPSVDILCNTAGILDAYKP
LLDVSDEEVEHLFDINFFATVKLTRHYLRHMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQI
HIFGIAPGAVKTAMTASDFEPGGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSMQGEIVKIDGGWTLK

Sequences:

>Translated_232_residues
MTKVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNFHFIKLDLSSELSPLFKVVPSVDILCNTAGILDAYKP
LLDVSDEEVEHLFDINFFATVKLTRHYLRHMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQI
HIFGIAPGAVKTAMTASDFEPGGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSMQGEIVKIDGGWTLK
>Mature_231_residues
TKVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNFHFIKLDLSSELSPLFKVVPSVDILCNTAGILDAYKPL
LDVSDEEVEHLFDINFFATVKLTRHYLRHMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIH
IFGIAPGAVKTAMTASDFEPGGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSMQGEIVKIDGGWTLK

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=29.2181069958848, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=28.099173553719, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=28.0632411067194, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI66933014, Length=176, Percent_Identity=29.5454545454545, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7705925, Length=237, Percent_Identity=25.7383966244726, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=26.3779527559055, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=27.6422764227642, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=30.8, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=28.9795918367347, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=30.7053941908714, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=26.6393442622951, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788459, Length=251, Percent_Identity=27.4900398406374, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787820, Length=191, Percent_Identity=30.8900523560209, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786701, Length=185, Percent_Identity=31.8918918918919, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=28.1632653061224, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1786812, Length=243, Percent_Identity=26.3374485596708, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=29.4605809128631, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI2367365, Length=234, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=29.2682926829268, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.4741035856574, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=29.8387096774194, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=26.4462809917355, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=27.9835390946502, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=25.8196721311475, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=30.4511278195489, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=27.0992366412214, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.1187739463602, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=25.7261410788382, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=26.615969581749, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=28.9473684210526, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=190, Percent_Identity=30.5263157894737, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=170, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=211, Percent_Identity=29.3838862559242, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=29.5081967213115, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI23397609, Length=242, Percent_Identity=29.7520661157025, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=30.5882352941176, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=26.9387755102041, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281364892, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358495, Length=225, Percent_Identity=26.2222222222222, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 25168; Mature: 25037

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNFHFIKLDLSSELSPLFK
CCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHH
VVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRHMVEKQSGVII
HHCCHHEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCEEE
NMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTASDFE
EHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCCCC
PGGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSMQGEIVKIDGGWTLK
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECC
>Mature Secondary Structure 
TKVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNFHFIKLDLSSELSPLFK
CEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHH
VVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRHMVEKQSGVII
HHCCHHEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCEEE
NMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTASDFE
EHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCCCCCC
PGGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSMQGEIVKIDGGWTLK
CCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]