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The map label for this gene is tmk [H]

Identifier: 94993722

GI number: 94993722

Start: 336320

End: 337081

Strand: Direct

Name: tmk [H]

Synonym: MGAS10750_Spy0326

Alternate gene names: 94993722

Gene position: 336320-337081 (Clockwise)

Preceding gene: 94993721

Following gene: 94993723

Centisome position: 17.36

GC content: 40.16

Gene sequence:

>762_bases
TTGACTGTCACTTCTTTAATAAGAACGGATAGGATTGGTCCTAAAATAGAGCACTGCAAAGATATGCCAGTGCTTTTTAG
CTCATTTTTTGATAAAATAGAACTACTAAAAAGTGAAGGAAATAAGATGATCACAGGAAAACTCATAACCGTTGAAGGTC
CAGATGGCGCAGGGAAAACGACTGTTTTAGAGCAACTCATTCCACTGTTAAAACAAAAAGTGGCTCAGGAGATCTTGACA
ACAAGAGAGCCTGGAGGTGTTGCCATTTCAGAATATATTAGAGAACTTATTTTAGACATCAACCATACTACTATGGACCC
TAAAACAGAACTCTTACTTTATATTGCGGCTCGAAGGCAGCATTTGGTAGAAAAGGTACTACCAGCTCTTGAAGCAGGCC
GGTTGGTTTTTATTGATCGTTTCATCGATAGTTCAGTAGCTTATCAAGGTGCGGGACGCGGTTTGATCAAAGCAGACATT
CAGTGGCTCAACGAGTTCGCAACAGATGGTTTAGAGCCTGACTTGACCCTTTATTTTGATGTTCCTTCTGAAATTGGTTT
AGCACGGATTAACGCGAACCAACAAAGAGAAGTCAATCGTTTAGATTTGGAAACAATAGAGATACATCAACGAGTACGAA
AAGGATACCTAGCCTTAGCTAAGGAGCATCCAAAACGTATTGTCACAATTGATGCGACTAAACCATTGAAAGAAGTTGTC
TCTGTCGCTTTGGAACATGTCTTAGCCTTGCTTTTAGCCTAG

Upstream 100 bases:

>100_bases
CGTTTCAGATTTAGTTAGCTTATTAAAGTAAGAAGGTTTTGACAGATGCTCACACTACTTCAAGACAATGAGACAACTAG
AGCATTAGTGAATAACTGAG

Downstream 100 bases:

>100_bases
GATAAGGGAGGGTAGGAATGGATTTAGCGCAAAAAGCTCCTAACGTTTATCAAGCTTTTCAGACGATTTTAAAGAAAGAC
CGTCTGAATCATGCTTATCT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTVTSLIRTDRIGPKIEHCKDMPVLFSSFFDKIELLKSEGNKMITGKLITVEGPDGAGKTTVLEQLIPLLKQKVAQEILT
TREPGGVAISEYIRELILDINHTTMDPKTELLLYIAARRQHLVEKVLPALEAGRLVFIDRFIDSSVAYQGAGRGLIKADI
QWLNEFATDGLEPDLTLYFDVPSEIGLARINANQQREVNRLDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVV
SVALEHVLALLLA

Sequences:

>Translated_253_residues
MTVTSLIRTDRIGPKIEHCKDMPVLFSSFFDKIELLKSEGNKMITGKLITVEGPDGAGKTTVLEQLIPLLKQKVAQEILT
TREPGGVAISEYIRELILDINHTTMDPKTELLLYIAARRQHLVEKVLPALEAGRLVFIDRFIDSSVAYQGAGRGLIKADI
QWLNEFATDGLEPDLTLYFDVPSEIGLARINANQQREVNRLDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVV
SVALEHVLALLLA
>Mature_252_residues
TVTSLIRTDRIGPKIEHCKDMPVLFSSFFDKIELLKSEGNKMITGKLITVEGPDGAGKTTVLEQLIPLLKQKVAQEILTT
REPGGVAISEYIRELILDINHTTMDPKTELLLYIAARRQHLVEKVLPALEAGRLVFIDRFIDSSVAYQGAGRGLIKADIQ
WLNEFATDGLEPDLTLYFDVPSEIGLARINANQQREVNRLDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVVS
VALEHVLALLLA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=198, Percent_Identity=41.9191919191919, Blast_Score=127, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 28308; Mature: 28177

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTSLIRTDRIGPKIEHCKDMPVLFSSFFDKIELLKSEGNKMITGKLITVEGPDGAGKT
CCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHH
TVLEQLIPLLKQKVAQEILTTREPGGVAISEYIRELILDINHTTMDPKTELLLYIAARRQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
HLVEKVLPALEAGRLVFIDRFIDSSVAYQGAGRGLIKADIQWLNEFATDGLEPDLTLYFD
HHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
VPSEIGLARINANQQREVNRLDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVV
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
SVALEHVLALLLA
HHHHHHHHHHHHC
>Mature Secondary Structure 
TVTSLIRTDRIGPKIEHCKDMPVLFSSFFDKIELLKSEGNKMITGKLITVEGPDGAGKT
CHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHH
TVLEQLIPLLKQKVAQEILTTREPGGVAISEYIRELILDINHTTMDPKTELLLYIAARRQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
HLVEKVLPALEAGRLVFIDRFIDSSVAYQGAGRGLIKADIQWLNEFATDGLEPDLTLYFD
HHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
VPSEIGLARINANQQREVNRLDLETIEIHQRVRKGYLALAKEHPKRIVTIDATKPLKEVV
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHH
SVALEHVLALLLA
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]