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The map label for this gene is hlyX [C]

Identifier: 94993707

GI number: 94993707

Start: 320996

End: 322369

Strand: Direct

Name: hlyX [C]

Synonym: MGAS10750_Spy0311

Alternate gene names: 94993707

Gene position: 320996-322369 (Clockwise)

Preceding gene: 94993706

Following gene: 94993708

Centisome position: 16.57

GC content: 38.5

Gene sequence:

>1374_bases
ATGAAGTCACTATATTATTTTTTTAGGAGTTACATTAACATGGAAGACCCTGTGAGTCAGCCCTTAGTGATTCAATTTTT
ATTGTTAGTTGTTTTAACCTTGTTAAATGCTTTTTTTTCAGCCAGTGAAATGGCCTTAGTTTCTCTCAATCGTTCTCGGG
TGGAACAAAAAGCAGCAGACGGTGATAAAAAATACGCTCGTTTGTTGCGGGTTTTAGAGGAACCTAATCATTTTTTATCA
ACGATTCAAGTTGGGATTACCTTTATTAGTTTACTATCAGGAGCAAGTTTATCAGCTTCTTTGGGTAAGGTGATCTCAGG
TTGGCTAGGTAATTCAGCGACTGCAAGGACAGCTGGTACTATCATCTCCTTGGTTTTCTTGACTTATGTCTCTATTGTTT
TAGGAGAATTGTATCCAAAACGGATTGCCATGAACCTCAAAGACAAGTTGGCGATCGTTTCAGCCCCTATTATCATTGGG
TTGGGGAGACTGGTTAGTCCTTTTGTGTGGCTCTTATCTGCTTCTACTAATTTGCTGAGCCGACTTACCCCAATGACCTT
TGATGATGCAGATGAGCAAATGACACGTGATGAAATCGAGTATATGTTATCAAAAAGTGAGGCGACCCTTGATGCTGAAG
AAATTGAGATGTTGCAAGGAGTTTTCTCACTTGATGAAATGATGGCGCGTGAAGTCATGGTCCCAAGGACCGATGCTTTC
ATGATTGACATTAACGATGATCCGCTTGAAAATATTCAGGAAATCTTAAAACAAAGTTTTTCACGCATTCCTGTTTATGA
TGTGGATAAAGATAAAATTATCGGTCTCATCCACACTAAGCGTCTCTTGGAGTCAGGTTTCCGCCAGGGATTTGATCAGA
TTAACATGCGAAAAATGTTACAAGAACCTCTTTTTGTTCCCGAAACCATTTTTGTAGATGATCTCTTACGCCAGCTGCGC
AATACCCAAAATCAGATGGCTATTTTGCTAGATGAATATGGTGGTGTGGCAGGACTTGTGACTTTGGAAGACTTGCTTGA
AGAAATCGTCGGTGAAATCGATGATGAAACCGATAAAGCAGAACAATTTGTTCATGAGATTGGAGACAATACCTATATTG
TTGTTGGTACCATGACTTTAAATGAGTTTAATGACTATTTTGATACCGAACTAGAATCAGATGATGTAGATACCATTGCT
GGTTTTTATTTGACAGGTATCGGAACCATTCCAAGCCAGGAGCAAAAAGAAGCCTACGAAATAGATAACAAAGACAAACA
TTTAGTTCTAATCAACGATAAAGTCAAAGATGGCCGTATTACGAAATTAAAATTAATCCTGTCTAATATAGAACAGATTA
TTGAGGAAGACTAG

Upstream 100 bases:

>100_bases
CGTTTAGCCCTTATCCCTGTGTCAAGTCTACTAGAAGTTCTGCGATTATTTCGGTGGAAAAAGAAGAAATCCCATAGGCT
TTGGCTATAAATGTGATATA

Downstream 100 bases:

>100_bases
GCTCCATGCCTAGTCTTTTTGATGAAAAGTGTTATAATGAAAATGTAAAAACGTTTACAAGTAATGAAGGAGATGCAATG
ACTGAGAAAGATTATGGACA

Product: Magnesium and cobalt efflux protein corC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKSLYYFFRSYINMEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLEEPNHFLS
TIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIG
LGRLVSPFVWLLSASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAF
MIDINDDPLENIQEILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVDDLLRQLR
NTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIA
GFYLTGIGTIPSQEQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED

Sequences:

>Translated_457_residues
MKSLYYFFRSYINMEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLEEPNHFLS
TIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIG
LGRLVSPFVWLLSASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAF
MIDINDDPLENIQEILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVDDLLRQLR
NTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIA
GFYLTGIGTIPSQEQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED
>Mature_457_residues
MKSLYYFFRSYINMEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLEEPNHFLS
TIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIG
LGRLVSPFVWLLSASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAF
MIDINDDPLENIQEILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVDDLLRQLR
NTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIA
GFYLTGIGTIPSQEQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=382, Percent_Identity=32.9842931937173, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI40068055, Length=365, Percent_Identity=25.2054794520548, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI40068053, Length=365, Percent_Identity=25.2054794520548, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI94681046, Length=363, Percent_Identity=26.7217630853994, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI145693175, Length=382, Percent_Identity=29.5811518324607, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790664, Length=417, Percent_Identity=24.4604316546763, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786879, Length=225, Percent_Identity=34.2222222222222, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082033, Length=246, Percent_Identity=28.4552845528455, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788119, Length=225, Percent_Identity=31.1111111111111, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 51558; Mature: 51558

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLYYFFRSYINMEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAAD
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCC
GDKKYARLLRVLEEPNHFLSTIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGT
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHH
IISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLSASTNLLS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAF
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
MIDINDDPLENIQEILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKML
EEECCCCHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QEPLFVPETIFVDDLLRQLRNTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKA
HCCCCCCHHHHHHHHHHHHHCCHHHEEEEEHHCCCEEHHHHHHHHHHHHHHHCCCCHHHH
EQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQEQKEAYE
HHHHHHHCCCCEEEEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHC
IDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSLYYFFRSYINMEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAAD
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCC
GDKKYARLLRVLEEPNHFLSTIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGT
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHH
IISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLSASTNLLS
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAF
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
MIDINDDPLENIQEILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKML
EEECCCCHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QEPLFVPETIFVDDLLRQLRNTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKA
HCCCCCCHHHHHHHHHHHHHCCHHHEEEEEHHCCCEEHHHHHHHHHHHHHHHCCCCHHHH
EQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQEQKEAYE
HHHHHHHCCCCEEEEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHC
IDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]