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The map label for this gene is covS [H]

Identifier: 94993674

GI number: 94993674

Start: 292330

End: 293832

Strand: Direct

Name: covS [H]

Synonym: MGAS10750_Spy0278

Alternate gene names: 94993674

Gene position: 292330-293832 (Clockwise)

Preceding gene: 94993673

Following gene: 94993675

Centisome position: 15.09

GC content: 35.4

Gene sequence:

>1503_bases
ATGGAAAATCAGAAACAAAAACAGAAGAAATATAAAAACTCGTTACCAAAACGACTATCTAATATCTTTTTTGTTCTTTT
TTTCTGCATTTTCTCTGCCTTTACACTGATTGCCTATAGTTCAACAAACTATTTCTTATTGAAGAAAGAAAAGCAGTCAG
TTTTTCAAGCTGTAAATATTGTTAGAGTTCGTCTTTCTGAGGTGGACTCTAATTTTACATTAGAGAACTTAGCAGAAGTT
TTGTACAAAAACGATAAAACACATCTGAGAATTGATGACAGAAAGGGCAGTCGAGTCATTAGGAGTGAGCGCGATATCAC
AAATACTCTAGATGCGAATCAAGATATTTATGTCTATAACATTGATAAACAGATGATTTTTACCACAGATAATGAAGAAT
CATCTCCTGGCTTGCATGGTCCTATCGGTCGGGTGTATCACGACCATATCGAAGATCAGTATCGTGGGTTTTCCATGACA
CAAAAGGTATATTCTAATCGGACTGGAAAATTTGTGGGCTATGTTCAAGTCTTTCATGATTTAGGCAATTATTATGTCAT
TAGAGCAAGACTGCTGTTTTGGCTACTAGTTGTTGAGTTATTTGGCACAAGCTTAGCCTATTTAATCATCTTAATTACTA
CGCGGCGCTTTTTGAAGCCTTTACACAATTTACATGAAGTAATGCGTAATATCTCTGAAAATCCTAATAATTTAAACCTG
CGCTCAGATATTTCGTCAGGAGATGAAATCGAAGAATTGTCTGTTATCTTTGACAATATGTTAGACAAATTGGAGACACA
TACTAAGTTGCAATCACGTTTTATTAGTGATGTCAGCCATGAATTACGAACACCGGTTGCGATTATTAAAGGGCATATTG
GTCTCTTACAACGTTGGGGTAAAGATGACAGTGATATTCTTGAAGAAAGTTTGACAGCAACAGCGCATGAGGCTGACCGT
ATGGCAATCATGATTAATGATATGTTAGACATGATTCGCGTACAAGGCTCATTTGAGGGACATCAAAATGATATGACAGT
TTTGGAAGATTCTATTGAAACTGTTGTTGGTAATTTTAGAGTTTTAAGAGAAGATTTTATCTTTACATGGCAGTCAGAAA
ATCCAAAAACGATAGCCCGTATTTATAAAAATCATTTTGAGCAGGCTTTGATGATTCTTATTGACAATGCTGTGAAGTAT
TCCCGTAAAGAAAAGAAAATCGCGATTAACCTTTCAGTGACTGGCAAACAAGAAGCTATTGTTAGAGTTCAAGATAAAGG
CGAAGGAATTTCTAAAGAAGATATTGAACATATCTTTGAACGCTTTTATAGAACGGATAAATCACGTAATCGAACAAGTA
CTCAGGCTGGATTAGGGATTGGCTTGTCTATTCTCAAGCAAATTGTAGATGGGTATCATTTACAGATGAAGGTTGAAAGT
GAATTAAATGAAGGTTCAGTGTTTATCTTACATATTCCTTTGGCCCAGTCTAACGAGAGTTAG

Upstream 100 bases:

>100_bases
ATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTTATATCCAAACAGTGCGTGGCATGGGATACGTT
ATTCGTGAGAAATAAGTCAT

Downstream 100 bases:

>100_bases
AGTAGCTTAAGGCATTGTTAATGTGACAGGTATAGTATGTAATCATTAGATAATAGTAGCAGGCTTTTGCCACAACTGGT
TAGAAGCTGATGCTATTTTT

Product: transmembrane histidine kinase CsrS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKEKQSVFQAVNIVRVRLSEVDSNFTLENLAEV
LYKNDKTHLRIDDRKGSRVIRSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMT
QKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNL
RSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWGKDDSDILEESLTATAHEADR
MAIMINDMLDMIRVQGSFEGHQNDMTVLEDSIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKY
SRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVES
ELNEGSVFILHIPLAQSNES

Sequences:

>Translated_500_residues
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKEKQSVFQAVNIVRVRLSEVDSNFTLENLAEV
LYKNDKTHLRIDDRKGSRVIRSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMT
QKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNL
RSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWGKDDSDILEESLTATAHEADR
MAIMINDMLDMIRVQGSFEGHQNDMTVLEDSIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKY
SRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVES
ELNEGSVFILHIPLAQSNES
>Mature_500_residues
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKEKQSVFQAVNIVRVRLSEVDSNFTLENLAEV
LYKNDKTHLRIDDRKGSRVIRSERDITNTLDANQDIYVYNIDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMT
QKVYSNRTGKFVGYVQVFHDLGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNL
RSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWGKDDSDILEESLTATAHEADR
MAIMINDMLDMIRVQGSFEGHQNDMTVLEDSIETVVGNFRVLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKY
SRKEKKIAINLSVTGKQEAIVRVQDKGEGISKEDIEHIFERFYRTDKSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVES
ELNEGSVFILHIPLAQSNES

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=323, Percent_Identity=26.9349845201238, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=285, Percent_Identity=30.1754385964912, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=24.3816254416961, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=25.7918552036199, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=356, Percent_Identity=23.314606741573, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=24.7899159663866, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786912, Length=274, Percent_Identity=25.9124087591241, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=25.8687258687259, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=331, Percent_Identity=25.6797583081571, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789808, Length=285, Percent_Identity=25.2631578947368, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=256, Percent_Identity=24.21875, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57908; Mature: 57908

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKEKQSVFQAVNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
VRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKGSRVIRSERDITNTLDANQDIYVYN
HHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHCCHHHHHHCCCCCCEEEEE
IDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMTQKVYSNRTGKFVGYVQVFHD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHH
LGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
RSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
KDDSDILEESLTATAHEADRMAIMINDMLDMIRVQGSFEGHQNDMTVLEDSIETVVGNFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKYSRKEKKIAINLSVTGKQEAI
HEEHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEE
VRVQDKGEGISKEDIEHIFERFYRTDKSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVES
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHCCEEEEEEEEC
ELNEGSVFILHIPLAQSNES
CCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MENQKQKQKKYKNSLPKRLSNIFFVLFFCIFSAFTLIAYSSTNYFLLKKEKQSVFQAVNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
VRVRLSEVDSNFTLENLAEVLYKNDKTHLRIDDRKGSRVIRSERDITNTLDANQDIYVYN
HHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHCCHHHHHHCCCCCCEEEEE
IDKQMIFTTDNEESSPGLHGPIGRVYHDHIEDQYRGFSMTQKVYSNRTGKFVGYVQVFHD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHH
LGNYYVIRARLLFWLLVVELFGTSLAYLIILITTRRFLKPLHNLHEVMRNISENPNNLNL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
RSDISSGDEIEELSVIFDNMLDKLETHTKLQSRFISDVSHELRTPVAIIKGHIGLLQRWG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHC
KDDSDILEESLTATAHEADRMAIMINDMLDMIRVQGSFEGHQNDMTVLEDSIETVVGNFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VLREDFIFTWQSENPKTIARIYKNHFEQALMILIDNAVKYSRKEKKIAINLSVTGKQEAI
HEEHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEE
VRVQDKGEGISKEDIEHIFERFYRTDKSRNRTSTQAGLGIGLSILKQIVDGYHLQMKVES
EEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHCCEEEEEEEEC
ELNEGSVFILHIPLAQSNES
CCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA