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The map label for this gene is htpX [H]

Identifier: 94993671

GI number: 94993671

Start: 289708

End: 290604

Strand: Direct

Name: htpX [H]

Synonym: MGAS10750_Spy0275

Alternate gene names: 94993671

Gene position: 289708-290604 (Clockwise)

Preceding gene: 94993670

Following gene: 94993672

Centisome position: 14.96

GC content: 40.36

Gene sequence:

>897_bases
ATGCTTTATCAACAGATTTCACAAAATAAGCAACGAACAGTTGTTTTATTAGTTGTTTTCTTCGCTCTCTTAGCACTTAT
TGGAGCGTCAGCAGGCTATCTGCTGTTAGATAATTATGCCATGGGCTTGGTTCTTGCTCTTGTCATTGGGGTGATTTATG
CTACCAGTATGATTTTTCAATCCACCAGTCTTGTAATGAGTATGAACAATGCTAGAGAAGTTACAGAAAAAGAGGCTCCA
GGCTTCTTCCATATTGTCGAGGATATGGCTATGGTAGCTCAGATTCCGATGCCGAGAGTTTTTATTATTGAAGATCCTTC
TTTAAATGCTTTTGCGACAGGATCTAGCCCTCAAAATGCTGCTGTTGCAGCAACGACAGGTTTACTTGAAGTCATGAATC
GTGAAGAACTTGAAGGTGTTATCGGCCATGAAATTAGCCACATCCGAAATTATGATATCCGTATTTCGACTATTGCTGTA
GCTTTGGCGAGTGCTGTTACCGTTATTTCTAGTATCGGTGGGCGTATGCTATGGTATGGTGGCGGTTCTCGCAGGCAAAG
AGATGACGGAGATGATGATGTTTTAAGAATCATTACATTACTTTTGTCGTTATTATCTTTGCTTTTAGCGCCCCTAGTAG
CAAGTTTGATTCAGTTGGCTATTTCTCGTCAAAGAGAATATCTAGCTGATGCTAGTTCTGTTGAACTAACAAGAAATCCC
CAAGGTATGATTAAGGCTCTTGAAAAATTGCAGTTATCTCAGCCAATGAAGCATCCTGTTGATGATGCTAGTGCGGCCTT
GTATATTAATGAGCCTCGCAAAAAAAGGAGCTTCAGTTCATTATTCAGCACCCATCCTCCTATTGAGGAGAGGATTGAAA
GGTTAAAAAACATGTGA

Upstream 100 bases:

>100_bases
TTACAAACACCAGAAGCTGAAAAAGAAGTTCCAAAAGTTGAATTTAACTTTTAAATATGAAATTATCATCTAGTAGGCAA
TCATAAGAGAAAGGAGAATT

Downstream 100 bases:

>100_bases
GCGTTTGGGGTTTTTGCTCAAGCCTCACTTTTTTATGTCTTTGGGCAGATAATCTAAAATGGCAGGAATTATCAAAAATA
TCTGAACAAAAAGAAAAAAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLYQQISQNKQRTVVLLVVFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAP
GFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM

Sequences:

>Translated_298_residues
MLYQQISQNKQRTVVLLVVFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAP
GFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
>Mature_298_residues
MLYQQISQNKQRTVVLLVVFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAP
GFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=217, Percent_Identity=38.2488479262673, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.-

Molecular weight: Translated: 32758; Mature: 32758

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQQISQNKQRTVVLLVVFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQ
CCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STSLVMSMNNAREVTEKEAPGFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNA
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCC
AVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAVALASAVTVISSIGGRMLWYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
GGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCH
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLYQQISQNKQRTVVLLVVFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQ
CCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STSLVMSMNNAREVTEKEAPGFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNA
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCC
AVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAVALASAVTVISSIGGRMLWYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
GGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCH
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]