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The map label for this gene is plr [H]

Identifier: 94993624

GI number: 94993624

Start: 240464

End: 241501

Strand: Direct

Name: plr [H]

Synonym: MGAS10750_Spy0228

Alternate gene names: 94993624

Gene position: 240464-241501 (Clockwise)

Preceding gene: 94993623

Following gene: 94993628

Centisome position: 12.41

GC content: 41.14

Gene sequence:

>1038_bases
TTGATTTTCATAAGGATGAAATCACTAATGGTAGTTAAAGTTGGTATTAACGGTTTCGGTCGTATCGGACGTCTTGCATT
CCGCCGTATTCAAAACATCGAAGGTGTTGAAGTAACTCGTATCAATGACCTTACAGATCCAAATATGCTTGCACACTTGT
TGAAATACGATACAACTCAAGGTCGTTTTGATGGAACAGTTGAAGTTAAAGAAGGTGGATTTGAAGTAAACGGAAACTTC
ATCAAAGTTTCTGCTGAACGTGATCCAGAAAACATCGACTGGGCAACTGATGGGGTTGAAATCGTTCTTGAAGCAACTGG
TTTCTTTGCTAAAAAAGAAGCAGCTGAAAAACACTTACATGCTAACGGTGCTAAAAAAGTTGTTATCACAGCTCCTGGTG
GAAACGATGTTAAAACAGTTGTTTTCAACACTAACCACGACATTCTTGACGGTACTGAAACAGTTATCTCAGGTGCTTCA
TGTACTACAAACTGTTTAGCTCCTATGGCTAAAGCTCTTCACGATGCATTCGGTATTCAAAAAGGTCTTATGACTACAAT
CCACGCTTACACTGGTGACCAAATGATCCTTGACGGACCACACCGTGGTGGTGACCTTCGTCGTGCACGCGCTGGTGCTG
CAAACATCGTTCCTAACTCAACTGGTGCTGCTAAAGCTATCGGTCTTGTTATCCCAGAACTTAACGGTAAACTTGACGGT
GCTGCACAACGTGTTCCTGTTCCAACTGGATCAGTAACTGAGTTGGTTGTAACTCTTGACAAAAACGTTTCTGTTGACGA
AATCAACGCTGCTATGAAAGCTGCTTCAAACGATAGCTTCGGTTACACTGAAGATCCAATCGTTTCTTCAGATATCGTAG
GCGTATCATACGGTTCATTGTTTGACGCAACTCAAACTAAAGTAATGGAAGTTGACGGATCACAATTGGTTAAAGTTGTA
TCATGGTATGACAACGAAATGTCTTACACTGCTCAACTTGTACGTACTCTTGAGTACTTCGCAAAAATTGCTAAATAA

Upstream 100 bases:

>100_bases
GAAATAGTTATATAATAGTTCTGTTGAAAGGTTGTTGCAGATGACTGTAAGTTAATCTTTTCACAATAGGTAGGGAGCAT
TCCCTCTAAATAATATTCTT

Downstream 100 bases:

>100_bases
TTAGTTATAACGAAAGAGAGCTTGGTTTATGCTGAGTTCTTTTTCGTATACTTTAAACACTACCTTAAATGTATGATTTT
AACGTTTTGAACTATTCTAG

Product: glyceraldehyde 3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH; Plasmin receptor; Plasminogen-binding protein [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MIFIRMKSLMVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNF
IKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGAS
CTTNCLAPMAKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDG
AAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVV
SWYDNEMSYTAQLVRTLEYFAKIAK

Sequences:

>Translated_345_residues
MIFIRMKSLMVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNF
IKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGAS
CTTNCLAPMAKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDG
AAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVV
SWYDNEMSYTAQLVRTLEYFAKIAK
>Mature_345_residues
MIFIRMKSLMVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNF
IKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGAS
CTTNCLAPMAKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDG
AAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVV
SWYDNEMSYTAQLVRTLEYFAKIAK

Specific function: Also binds human plasminogen [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=335, Percent_Identity=46.2686567164179, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI7657116, Length=332, Percent_Identity=43.3734939759036, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI1788079, Length=338, Percent_Identity=50.2958579881657, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1789295, Length=343, Percent_Identity=38.7755102040816, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=45.5882352941176, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=45.5882352941176, Blast_Score=266, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17534677, Length=340, Percent_Identity=45.5882352941176, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=45.5882352941176, Blast_Score=263, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6322409, Length=338, Percent_Identity=44.3786982248521, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6321631, Length=338, Percent_Identity=45.5621301775148, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6322468, Length=338, Percent_Identity=45.5621301775148, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=46.6867469879518, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=46.6867469879518, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI85725000, Length=332, Percent_Identity=46.3855421686747, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI22023983, Length=332, Percent_Identity=46.3855421686747, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=44.7129909365559, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 37064; Mature: 37064

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFIRMKSLMVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQ
CEEEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCC
GRFDGTVEVKEGGFEVNGNFIKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLH
CCCCCEEEEECCCEEECCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHC
ANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPMAKALHDAFGIQ
CCCCCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDG
HHHHHEEEEECCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCC
AAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSL
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCH
FDATQTKVMEVDGSQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
HCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFIRMKSLMVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQ
CEEEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCC
GRFDGTVEVKEGGFEVNGNFIKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLH
CCCCCEEEEECCCEEECCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHC
ANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPMAKALHDAFGIQ
CCCCCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDG
HHHHHEEEEECCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCC
AAQRVPVPTGSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSL
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCH
FDATQTKVMEVDGSQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
HCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8706717 [H]