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The map label for this gene is dut [H]

Identifier: 94993590

GI number: 94993590

Start: 205277

End: 205723

Strand: Direct

Name: dut [H]

Synonym: MGAS10750_Spy0194

Alternate gene names: 94993590

Gene position: 205277-205723 (Clockwise)

Preceding gene: 94993589

Following gene: 94993591

Centisome position: 10.6

GC content: 41.83

Gene sequence:

>447_bases
ATGACAAAAATTCGTGGTTTCGAGCTTGTTTCAAGCTTTACTAATAATGATTTACTACCAAAACGTGAGACGACTCATGC
AGCTGGTTATGACCTGTCTGTTGCTGAGGCTGTAACCATTGCCCCAGGGGAGATTAAGTTGGTACCAACAGGGGTTAAGG
CCTATATGCAAGATGGTGAGGTGCTTTACCTCTATGATCGTTCGTCAAATCCACGAAAAAAAGGGATTATCATGATTAAT
TCAGTAGGTGTGATTGATGCAGATTATTATGGCAATGAGGCTAATGAAGGACATATTTTTGCACAAATGCAAAACATTAT
AGATCACCCTGTGACATTAGCTGTGGGTGAGAGGATCGTTCAGGGTGTTTTTATGCCTTTTTTAATTGCTGATGGTGACC
AAGCCAGAGGTGAACGAACAGGTGGTTTTGGTTCGACAGGGCAGTAA

Upstream 100 bases:

>100_bases
TAAAAGTGGTCCGTTTAAAGTTGACCGCTTTTTTGCTATTCTTTTACGAATAGTCTATAATAAGAGGATATGATTGACTT
GAAAGGATATACCTATCATA

Downstream 100 bases:

>100_bases
AGCGATTTAACAAAAATGCTTATGACAGCAGACCTATTCTTTAAGAGTGGGTTTGTCTTGTCTAGGGGAGGGAGATTACT
ATGGCAAAGAAAAAAGCAAC

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MTKIRGFELVSSFTNNDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPTGVKAYMQDGEVLYLYDRSSNPRKKGIIMIN
SVGVIDADYYGNEANEGHIFAQMQNIIDHPVTLAVGERIVQGVFMPFLIADGDQARGERTGGFGSTGQ

Sequences:

>Translated_148_residues
MTKIRGFELVSSFTNNDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPTGVKAYMQDGEVLYLYDRSSNPRKKGIIMIN
SVGVIDADYYGNEANEGHIFAQMQNIIDHPVTLAVGERIVQGVFMPFLIADGDQARGERTGGFGSTGQ
>Mature_147_residues
TKIRGFELVSSFTNNDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPTGVKAYMQDGEVLYLYDRSSNPRKKGIIMINS
VGVIDADYYGNEANEGHIFAQMQNIIDHPVTLAVGERIVQGVFMPFLIADGDQARGERTGGFGSTGQ

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Escherichia coli, GI1790071, Length=140, Percent_Identity=36.4285714285714, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16066; Mature: 15935

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIRGFELVSSFTNNDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPTGVKAYMQDGE
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEECCCEEEEEECCHHHHHCCCC
VLYLYDRSSNPRKKGIIMINSVGVIDADYYGNEANEGHIFAQMQNIIDHPVTLAVGERIV
EEEEEECCCCCCCCCEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
QGVFMPFLIADGDQARGERTGGFGSTGQ
HHHHHHEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKIRGFELVSSFTNNDLLPKRETTHAAGYDLSVAEAVTIAPGEIKLVPTGVKAYMQDGE
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEECCCEEEEEECCHHHHHCCCC
VLYLYDRSSNPRKKGIIMINSVGVIDADYYGNEANEGHIFAQMQNIIDHPVTLAVGERIV
EEEEEECCCCCCCCCEEEEECCCEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
QGVFMPFLIADGDQARGERTGGFGSTGQ
HHHHHHEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]