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The map label for this gene is tadA [H]

Identifier: 94993570

GI number: 94993570

Start: 188229

End: 188768

Strand: Direct

Name: tadA [H]

Synonym: MGAS10750_Spy0174

Alternate gene names: 94993570

Gene position: 188229-188768 (Clockwise)

Preceding gene: 94993569

Following gene: 94993572

Centisome position: 9.72

GC content: 45.19

Gene sequence:

>540_bases
TTGGAACTTGGGGAGTCTTTCTTGATGCCATATAGTTTAGAAGAGCAAACTTATTTCATGCAAGAGGCTTTAAAAGAAGC
CGAAAAATCCTTACAGAAAGCTGAAATCCCCATTGGCTGTGTCATTGTCAAGGATGGTGAGATTATTGGTCGTGGGCACA
ATGCGCGTGAAGAGAGTAACCAAGCCATTATGCACGCTGAAATGATGGCCATTAACGAGGCTAACGCTCATGAAGGCAAC
TGGCGTTTATTAGACACCACACTCTTTGTGACCATCGAGCCTTGTGTGATGTGTAGTGGTGCTATTGGGCTAGCAAGGAT
TCCGCATGTTATTTATGGAGCCAGCAATCAAAAATTTGGTGGAGCAGACAGCCTTTACCAGATTTTGACAGATGAGCGCT
TAAACCACCGCGTGCAAGTTGAACGAGGCCTGCTAGCAGCAGACTGTGCTAACATCATGCAAACCTTTTTCCGCCAAGGG
CGAGAGCGCAAAAAAATAGCTAAGCATTTGATCAAGGAACAGTCAGATCCCTTTGATTAG

Upstream 100 bases:

>100_bases
CAGAAGGTATTAATTCCAAAAACCATTTAGAAGTGTTGAGGCAAGAAACACAGGCCTATGCAGGTAATATTCCTGTTGAC
CTTGCCTTACCACACAAATC

Downstream 100 bases:

>100_bases
AGTTTTAAGGAGCTTGTTATCACATGCATTTTTGGTGAAGGGTAACCTGTCAAAATAATGAGTGAAACGTTAGACCATTT
TTCCAATGGTTGTTAGATTC

Product: tRNA-specific adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MELGESFLMPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGN
WRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQG
RERKKIAKHLIKEQSDPFD

Sequences:

>Translated_179_residues
MELGESFLMPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGN
WRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQG
RERKKIAKHLIKEQSDPFD
>Mature_179_residues
MELGESFLMPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGN
WRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQG
RERKKIAKHLIKEQSDPFD

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=156, Percent_Identity=33.974358974359, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI145693172, Length=151, Percent_Identity=40.3973509933775, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541138, Length=148, Percent_Identity=35.1351351351351, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17554608, Length=129, Percent_Identity=32.5581395348837, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322425, Length=118, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325319, Length=96, Percent_Identity=37.5, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355527, Length=146, Percent_Identity=32.1917808219178, Blast_Score=87, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 20168; Mature: 20168

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGESFLMPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHH
QAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECHHHHHCCCHHHHHHCHHEECCCCCCCC
GADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAKHLIKEQSDPFD
CHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MELGESFLMPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHH
QAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECHHHHHCCCHHHHHHCHHEECCCCCCCC
GADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAKHLIKEQSDPFD
CHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]