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The map label for this gene is fdhA [H]

Identifier: 94986395

GI number: 94986395

Start: 2416258

End: 2417397

Strand: Reverse

Name: fdhA [H]

Synonym: Dgeo_2296

Alternate gene names: 94986395

Gene position: 2417397-2416258 (Counterclockwise)

Preceding gene: 94986396

Following gene: 94986394

Centisome position: 97.98

GC content: 60.44

Gene sequence:

>1140_bases
ATGAAAGCTGTCATTTACAACGGACCGCGTGATGTTCGCGTTGTCGACGTGGCCGACCCCCAGATTGAGCAACCCACAGA
TGTGCTGGTGAAAATCACGAGTACCAACATCTGCGGTTCCGACCTGCACATGTACGAGGGCCGCACCGACATCGAGTGCG
GGCGGGTGCTTGGGCATGAAAACCTGGGTGAAGTGGTGGAAATCGGCCGGGCGGTGTACCGCATTAAGGTGGGTGACAAG
GTCTGTCTGCCGTTTAATATCGGCTGTGGCTTCTGCCGTAACTGCGAAAAGGGGTTGACTGGAGCCTGCCTGACGGTGGC
GCCGGGTCAGGCCGGGGCTGCCTACGGGTTTGCCGACATGGGCCCGTTTCAGGGTGGACAGGCCCAGTACTTGCGGGTGC
CCTTCGGTGATTTCAACTGCCTGAAGCTCCCCGAGGACGCCGCCGAGAAAGAGGACGACTATGTGATGCTGGCCGACATT
TTTCCGACGGGCTGGCACGCCACGCGGCTCGCCAATCTGATGCCCGGCGAGAGCGTCGCGATTTACGGGGCGGGACCAGT
GGGGCTGATGGCGGCCTACTCCGCCATGATTCAGGGGGCCCGGCAAGTCATCGTGGTCGACCGCCACAAGGATCGCCTGA
AGCTGGCCGAACAGATCGGAGCGATTGCTGTCAACGACGCCGAACACGACCCGGTCGAACAGATCATGGAACTGACGAAC
GGCCGGGGGACCGATAAGGGCTGTGAATGTGTGGGCTGGCAGTGCCACGACCACGGGGGACATGAGATCCCCAACCTGAC
CATGAACAATCTGGTGAAGACCACTCGCGCCACCGGGCAGATCGGCGTGGTGGGTGTCTTCGTTCCGCAGGATCCGAAAT
CGCCGGACGACCTGATGAAGCGTGGTCAGATTGCCTTCGACATCGGCAATTTCTTCTTCAAGGGCCTGCGGATGGGTTCG
GGGCAAGCCAACGTGAAGGCGTATAACCGGGAGTTGCGCGACCTGATTCACGCTGATCGTGCCAAGCCATCATTCCTGGT
GTCGCACCGCCTGCCGCTGGAACAGGCCCCCGACGCATACAAAAACTTCGATAACCGCATAGACGGCTGGACGAAGGTGA
TCCTCAAACCCAACGAGTAG

Upstream 100 bases:

>100_bases
CGATCAATCCCAAAGCGGTCTAAGCCCCCGCCACGCCAGAACGAACCAAGAGCAGGAATGGGACTCCGGGTCACCGATAC
GCCGGAGTTGGAGGTTTCAT

Downstream 100 bases:

>100_bases
GAACGAACAGGTGCGACCCTCCGCACCGGTTCTGGCAACTTAAGCGTGAACGGAAAAGAAGACCGACTGGGCAGCCTGAA
ATTCAGGCTGCCTGTTGCAT

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKAVIYNGPRDVRVVDVADPQIEQPTDVLVKITSTNICGSDLHMYEGRTDIECGRVLGHENLGEVVEIGRAVYRIKVGDK
VCLPFNIGCGFCRNCEKGLTGACLTVAPGQAGAAYGFADMGPFQGGQAQYLRVPFGDFNCLKLPEDAAEKEDDYVMLADI
FPTGWHATRLANLMPGESVAIYGAGPVGLMAAYSAMIQGARQVIVVDRHKDRLKLAEQIGAIAVNDAEHDPVEQIMELTN
GRGTDKGCECVGWQCHDHGGHEIPNLTMNNLVKTTRATGQIGVVGVFVPQDPKSPDDLMKRGQIAFDIGNFFFKGLRMGS
GQANVKAYNRELRDLIHADRAKPSFLVSHRLPLEQAPDAYKNFDNRIDGWTKVILKPNE

Sequences:

>Translated_379_residues
MKAVIYNGPRDVRVVDVADPQIEQPTDVLVKITSTNICGSDLHMYEGRTDIECGRVLGHENLGEVVEIGRAVYRIKVGDK
VCLPFNIGCGFCRNCEKGLTGACLTVAPGQAGAAYGFADMGPFQGGQAQYLRVPFGDFNCLKLPEDAAEKEDDYVMLADI
FPTGWHATRLANLMPGESVAIYGAGPVGLMAAYSAMIQGARQVIVVDRHKDRLKLAEQIGAIAVNDAEHDPVEQIMELTN
GRGTDKGCECVGWQCHDHGGHEIPNLTMNNLVKTTRATGQIGVVGVFVPQDPKSPDDLMKRGQIAFDIGNFFFKGLRMGS
GQANVKAYNRELRDLIHADRAKPSFLVSHRLPLEQAPDAYKNFDNRIDGWTKVILKPNE
>Mature_379_residues
MKAVIYNGPRDVRVVDVADPQIEQPTDVLVKITSTNICGSDLHMYEGRTDIECGRVLGHENLGEVVEIGRAVYRIKVGDK
VCLPFNIGCGFCRNCEKGLTGACLTVAPGQAGAAYGFADMGPFQGGQAQYLRVPFGDFNCLKLPEDAAEKEDDYVMLADI
FPTGWHATRLANLMPGESVAIYGAGPVGLMAAYSAMIQGARQVIVVDRHKDRLKLAEQIGAIAVNDAEHDPVEQIMELTN
GRGTDKGCECVGWQCHDHGGHEIPNLTMNNLVKTTRATGQIGVVGVFVPQDPKSPDDLMKRGQIAFDIGNFFFKGLRMGS
GQANVKAYNRELRDLIHADRAKPSFLVSHRLPLEQAPDAYKNFDNRIDGWTKVILKPNE

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=334, Percent_Identity=28.7425149700599, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4501933, Length=324, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=258, Percent_Identity=28.6821705426357, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI71565152, Length=378, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501939, Length=254, Percent_Identity=25.1968503937008, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI156523966, Length=254, Percent_Identity=25.1968503937008, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI71743840, Length=262, Percent_Identity=26.3358778625954, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI262073058, Length=262, Percent_Identity=26.3358778625954, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786825, Length=403, Percent_Identity=37.2208436724566, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1790045, Length=377, Percent_Identity=31.2997347480106, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87082125, Length=368, Percent_Identity=29.3478260869565, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788073, Length=257, Percent_Identity=32.295719844358, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787863, Length=387, Percent_Identity=25.8397932816537, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=27.1676300578035, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788407, Length=240, Percent_Identity=30.4166666666667, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788075, Length=372, Percent_Identity=26.8817204301075, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081918, Length=217, Percent_Identity=30.8755760368664, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=297, Percent_Identity=29.96632996633, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790718, Length=285, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=344, Percent_Identity=27.906976744186, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=262, Percent_Identity=30.1526717557252, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=323, Percent_Identity=28.1733746130031, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=372, Percent_Identity=26.8817204301075, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=370, Percent_Identity=28.3783783783784, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=370, Percent_Identity=28.3783783783784, Blast_Score=119, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6323099, Length=271, Percent_Identity=31.7343173431734, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=286, Percent_Identity=28.6713286713287, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=285, Percent_Identity=25.9649122807018, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=249, Percent_Identity=31.7269076305221, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137530, Length=258, Percent_Identity=29.4573643410853, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737897, Length=258, Percent_Identity=29.4573643410853, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550770, Length=373, Percent_Identity=26.2734584450402, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221457811, Length=373, Percent_Identity=26.2734584450402, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551930, Length=373, Percent_Identity=26.2734584450402, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737895, Length=376, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 41400; Mature: 41400

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIYNGPRDVRVVDVADPQIEQPTDVLVKITSTNICGSDLHMYEGRTDIECGRVLGHE
CCEEEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCHHHHHCCC
NLGEVVEIGRAVYRIKVGDKVCLPFNIGCGFCRNCEKGLTGACLTVAPGQAGAAYGFADM
CHHHHHHHCCEEEEEEECCEEEEEEECCCCHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
GPFQGGQAQYLRVPFGDFNCLKLPEDAAEKEDDYVMLADIFPTGWHATRLANLMPGESVA
CCCCCCCEEEEEECCCCCCEEECCCHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEE
IYGAGPVGLMAAYSAMIQGARQVIVVDRHKDRLKLAEQIGAIAVNDAEHDPVEQIMELTN
EEECCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHC
GRGTDKGCECVGWQCHDHGGHEIPNLTMNNLVKTTRATGQIGVVGVFVPQDPKSPDDLMK
CCCCCCCCEEECEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHH
RGQIAFDIGNFFFKGLRMGSGQANVKAYNRELRDLIHADRAKPSFLVSHRLPLEQAPDAY
CCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHCCCHHH
KNFDNRIDGWTKVILKPNE
HHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MKAVIYNGPRDVRVVDVADPQIEQPTDVLVKITSTNICGSDLHMYEGRTDIECGRVLGHE
CCEEEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCHHHHHCCC
NLGEVVEIGRAVYRIKVGDKVCLPFNIGCGFCRNCEKGLTGACLTVAPGQAGAAYGFADM
CHHHHHHHCCEEEEEEECCEEEEEEECCCCHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
GPFQGGQAQYLRVPFGDFNCLKLPEDAAEKEDDYVMLADIFPTGWHATRLANLMPGESVA
CCCCCCCEEEEEECCCCCCEEECCCHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEE
IYGAGPVGLMAAYSAMIQGARQVIVVDRHKDRLKLAEQIGAIAVNDAEHDPVEQIMELTN
EEECCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCEEEECCCCCCHHHHHHHHHC
GRGTDKGCECVGWQCHDHGGHEIPNLTMNNLVKTTRATGQIGVVGVFVPQDPKSPDDLMK
CCCCCCCCEEECEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHH
RGQIAFDIGNFFFKGLRMGSGQANVKAYNRELRDLIHADRAKPSFLVSHRLPLEQAPDAY
CCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHCCCHHH
KNFDNRIDGWTKVILKPNE
HHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]