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The map label for this gene is fmt [H]

Identifier: 94986390

GI number: 94986390

Start: 2412059

End: 2413018

Strand: Reverse

Name: fmt [H]

Synonym: Dgeo_2291

Alternate gene names: 94986390

Gene position: 2413018-2412059 (Counterclockwise)

Preceding gene: 94986391

Following gene: 94986387

Centisome position: 97.8

GC content: 69.48

Gene sequence:

>960_bases
TTGAGCGCCCCCCGCGTCGCCTTTTTCGGCTCGCCCGCCTTCGCGCTGCCGGTGCTGGAAGCCATCCGCGAGCATTTTGA
GGTGGTGCTGGTCGTCACGCAGCCCGACAAACCGGTGGGCCGCGGTCTGAAGCTCACCCCGCCCCCGGTGGCTGCTCGCG
CCGCCGAACTTGGTTTGCCCCTTGCGCAGCCGAAGAGGCTGCGGGGCAACGTGGCCTTCGAGGCGCAGCTGCGCGCGAGC
GGCGCGGACGTGGCCGTGACCTGCGCCTACGGCAAGATGCTTCCGGCCTCGTTGCTTGCCGTTCCGCGTTTCGGCTTTCT
GAACACCCACACCAGCCTCCTTCCCGCCTACCGGGGGGCGGCGCCGATCCAGTGGGCGCTTATTCGCGGCGAGACCGTCA
CCGGGACGACCATCATGCAGACGGACGCCGGCATGGACACCGGGCCGATCCTGCTGCAGGAAGAATTGCCCATCGCGCCG
GAGTGGACCAGCATTGAACTCGCAGAAGCGCTGAGTGTCCAGGCAGCGCGGCTGATTGTGGAAGCCCTCCTCCACCTGCC
CGACCTGACGCCTGTTCCCCAGGACGAGACGTGGGCCACCTCTGCCCCCATGCTGGTGAAGGAGGACGGCTTCGTGCGGT
GGCAGGAGAGCGCGCTCGCTGTGGTGAACCGTTACCGCGGGGTGGCGGCTTGGCCGCAAACCACCGCCTTTTTGCAGGGC
GCGCGGCTGAAACTTGCAGGCCTGAGCGTGACGAACGGCCAGGGCCAGCCGGGCGAGGTGCTGCGCGTGGACGAGGAAGG
GCTGACCGTCGCGTGTGGCGAGGGCGCGGTGCGGGTGCAGACGGTCCAGCCCGAAGCGCGCAGGGCGCAAGCCGCGGCCG
CGTGGGCACAGGGGGCGGGTGTCGGGCCGGGGACGCGGTTCGACCTGTGGCAACCTGCGGCGGAGGACATAAAAAGCTGA

Upstream 100 bases:

>100_bases
CCGAGGACCACCGCAAGGAGCTGGCCGCCATGCAGCGCCAGGCGAAGGCGTACCTCCAAGGGTTGGCCGAGGCCGAGAAG
CGGCGGCGGGAGCAGGAAGG

Downstream 100 bases:

>100_bases
AGCCAGGATTGGGCGCTCGGCTTACTTCTCTCCGAAACTCGGCACGTTATTTCCGTAGATCGCGTGCGCGTCGCAGCGTG
CGCGCAGCACGCAGACCGGG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSAPRVAFFGSPAFALPVLEAIREHFEVVLVVTQPDKPVGRGLKLTPPPVAARAAELGLPLAQPKRLRGNVAFEAQLRAS
GADVAVTCAYGKMLPASLLAVPRFGFLNTHTSLLPAYRGAAPIQWALIRGETVTGTTIMQTDAGMDTGPILLQEELPIAP
EWTSIELAEALSVQAARLIVEALLHLPDLTPVPQDETWATSAPMLVKEDGFVRWQESALAVVNRYRGVAAWPQTTAFLQG
ARLKLAGLSVTNGQGQPGEVLRVDEEGLTVACGEGAVRVQTVQPEARRAQAAAAWAQGAGVGPGTRFDLWQPAAEDIKS

Sequences:

>Translated_319_residues
MSAPRVAFFGSPAFALPVLEAIREHFEVVLVVTQPDKPVGRGLKLTPPPVAARAAELGLPLAQPKRLRGNVAFEAQLRAS
GADVAVTCAYGKMLPASLLAVPRFGFLNTHTSLLPAYRGAAPIQWALIRGETVTGTTIMQTDAGMDTGPILLQEELPIAP
EWTSIELAEALSVQAARLIVEALLHLPDLTPVPQDETWATSAPMLVKEDGFVRWQESALAVVNRYRGVAAWPQTTAFLQG
ARLKLAGLSVTNGQGQPGEVLRVDEEGLTVACGEGAVRVQTVQPEARRAQAAAAWAQGAGVGPGTRFDLWQPAAEDIKS
>Mature_318_residues
SAPRVAFFGSPAFALPVLEAIREHFEVVLVVTQPDKPVGRGLKLTPPPVAARAAELGLPLAQPKRLRGNVAFEAQLRASG
ADVAVTCAYGKMLPASLLAVPRFGFLNTHTSLLPAYRGAAPIQWALIRGETVTGTTIMQTDAGMDTGPILLQEELPIAPE
WTSIELAEALSVQAARLIVEALLHLPDLTPVPQDETWATSAPMLVKEDGFVRWQESALAVVNRYRGVAAWPQTTAFLQGA
RLKLAGLSVTNGQGQPGEVLRVDEEGLTVACGEGAVRVQTVQPEARRAQAAAAWAQGAGVGPGTRFDLWQPAAEDIKS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=303, Percent_Identity=32.013201320132, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI238814322, Length=309, Percent_Identity=29.7734627831715, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI21614513, Length=241, Percent_Identity=33.195020746888, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1789683, Length=295, Percent_Identity=40.6779661016949, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788589, Length=296, Percent_Identity=30.7432432432432, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=279, Percent_Identity=26.8817204301075, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=26.8852459016393, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28571984, Length=226, Percent_Identity=28.3185840707965, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585660, Length=289, Percent_Identity=29.0657439446367, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33870; Mature: 33739

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPRVAFFGSPAFALPVLEAIREHFEVVLVVTQPDKPVGRGLKLTPPPVAARAAELGLP
CCCCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCC
LAQPKRLRGNVAFEAQLRASGADVAVTCAYGKMLPASLLAVPRFGFLNTHTSLLPAYRGA
CCCCHHHCCCEEEEEEEECCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHCCC
APIQWALIRGETVTGTTIMQTDAGMDTGPILLQEELPIAPEWTSIELAEALSVQAARLIV
CCEEEEEEECCEECCCEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
EALLHLPDLTPVPQDETWATSAPMLVKEDGFVRWQESALAVVNRYRGVAAWPQTTAFLQG
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHCC
ARLKLAGLSVTNGQGQPGEVLRVDEEGLTVACGEGAVRVQTVQPEARRAQAAAAWAQGAG
CEEEEEEEEEECCCCCCCCEEEECCCCCEEEECCCEEEEEEECCHHHHHHHHHHHHCCCC
VGPGTRFDLWQPAAEDIKS
CCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SAPRVAFFGSPAFALPVLEAIREHFEVVLVVTQPDKPVGRGLKLTPPPVAARAAELGLP
CCCCEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCC
LAQPKRLRGNVAFEAQLRASGADVAVTCAYGKMLPASLLAVPRFGFLNTHTSLLPAYRGA
CCCCHHHCCCEEEEEEEECCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHCCC
APIQWALIRGETVTGTTIMQTDAGMDTGPILLQEELPIAPEWTSIELAEALSVQAARLIV
CCEEEEEEECCEECCCEEEEECCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
EALLHLPDLTPVPQDETWATSAPMLVKEDGFVRWQESALAVVNRYRGVAAWPQTTAFLQG
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHCC
ARLKLAGLSVTNGQGQPGEVLRVDEEGLTVACGEGAVRVQTVQPEARRAQAAAAWAQGAG
CEEEEEEEEEECCCCCCCCEEEECCCCCEEEECCCEEEEEEECCHHHHHHHHHHHHCCCC
VGPGTRFDLWQPAAEDIKS
CCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]