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The map label for this gene is gmk

Identifier: 94986383

GI number: 94986383

Start: 2406815

End: 2407543

Strand: Reverse

Name: gmk

Synonym: Dgeo_2284

Alternate gene names: 94986383

Gene position: 2407543-2406815 (Counterclockwise)

Preceding gene: 94986384

Following gene: 94986377

Centisome position: 97.58

GC content: 62.69

Gene sequence:

>729_bases
ATGCTGCCTAGCATGATGGTTGCTCGGCCTGACCCACAAACCACTTCGTCCTCTTCTCACCGCGGCCTCCTGATCGTGAT
GACCGGCGCTTCGGGCGTCGGCAAGGGCACGCTGCGCGAGCGTTGGCTGGCTGGACAGGACGTGTTCTATTCAACCTCAT
GGACGACTCGTGAGGCGCGTCCCGGTGAACGTGACGGTGTGGATTACGTGTTCGTGACCCCTGAGGTGTTTCTGGAAAAG
GTTCGGCAGAACGGCTTTCTGGAACACGCCCAATTTGTGGGGAACCACTACGGCACGCCCACTGAACCCATTGAGGCGGC
ACTCGCACGTGGGCAGGACGTGGTGCTGGAGATCGAGGTCGAGGGGGCGATGCAGGTCAAGGAACGGATGGGCGAGGAGG
CGGTGCTGGTGTTTATCATGCCGCCCAGTCTGACCGAGCTGCGCCGCCGCCTGACCGGGCGCGCCACCGAGACGCCCGAG
CGTATTGAGAAACGCCTGCAGCGGGCCCGCGACGAGATCATGGCGGCCCACGCCTTTCGTTACGTGATTGTGAACGACGA
TCTGGACCGTGCCGTCCGTGAACTGCAGGCCGTCCAACGCGCCGAGCATGCACGGCAGCGCCCAGAAACCGAGTGGACGG
CAGAAGACCGGGCAGCGGTGCAGCTTGCCGAAACAGTACGGAGCACGGTCCTGACCACCGAAGATCTACAGCGGATTGTC
AACAGTTAA

Upstream 100 bases:

>100_bases
GCCGGAGCAAAACCAAGTCAAGGTAGCGCTTCAGCGCTCAGGTGGGCCAGGCGCGGCGGTTTTCCGTCTGCTCTGGCCCG
CTTTCCGTTCGCCGAGCCGT

Downstream 100 bases:

>100_bases
TGTTGCCCGCTCACCTCTGCAAAACGCCCTTGACGACCTGCACGACGTTCGGCACGTTGAAGCCGAATTTCTCAAAGAGG
ACTTTGGCTGGGGCCGAGGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLPSMMVARPDPQTTSSSSHRGLLIVMTGASGVGKGTLRERWLAGQDVFYSTSWTTREARPGERDGVDYVFVTPEVFLEK
VRQNGFLEHAQFVGNHYGTPTEPIEAALARGQDVVLEIEVEGAMQVKERMGEEAVLVFIMPPSLTELRRRLTGRATETPE
RIEKRLQRARDEIMAAHAFRYVIVNDDLDRAVRELQAVQRAEHARQRPETEWTAEDRAAVQLAETVRSTVLTTEDLQRIV
NS

Sequences:

>Translated_242_residues
MLPSMMVARPDPQTTSSSSHRGLLIVMTGASGVGKGTLRERWLAGQDVFYSTSWTTREARPGERDGVDYVFVTPEVFLEK
VRQNGFLEHAQFVGNHYGTPTEPIEAALARGQDVVLEIEVEGAMQVKERMGEEAVLVFIMPPSLTELRRRLTGRATETPE
RIEKRLQRARDEIMAAHAFRYVIVNDDLDRAVRELQAVQRAEHARQRPETEWTAEDRAAVQLAETVRSTVLTTEDLQRIV
NS
>Mature_242_residues
MLPSMMVARPDPQTTSSSSHRGLLIVMTGASGVGKGTLRERWLAGQDVFYSTSWTTREARPGERDGVDYVFVTPEVFLEK
VRQNGFLEHAQFVGNHYGTPTEPIEAALARGQDVVLEIEVEGAMQVKERMGEEAVLVFIMPPSLTELRRRLTGRATETPE
RIEKRLQRARDEIMAAHAFRYVIVNDDLDRAVRELQAVQRAEHARQRPETEWTAEDRAAVQLAETVRSTVLTTEDLQRIV
NS

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=177, Percent_Identity=39.5480225988701, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI4504221, Length=177, Percent_Identity=39.5480225988701, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI226874831, Length=177, Percent_Identity=39.5480225988701, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=28.5, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI38570142, Length=175, Percent_Identity=30.2857142857143, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI111154074, Length=155, Percent_Identity=28.3870967741935, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI52630447, Length=198, Percent_Identity=29.7979797979798, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI262118255, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4505237, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI262118259, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118263, Length=191, Percent_Identity=27.2251308900524, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI14780902, Length=206, Percent_Identity=25.2427184466019, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI21536464, Length=189, Percent_Identity=28.042328042328, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI186700629, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI186700627, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI186972120, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=188, Percent_Identity=42.5531914893617, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI193203132, Length=177, Percent_Identity=38.4180790960452, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=177, Percent_Identity=38.4180790960452, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=29.2817679558011, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=185, Percent_Identity=29.1891891891892, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=27.3224043715847, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=42.8571428571429, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356141, Length=177, Percent_Identity=37.8531073446328, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45554489, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161077626, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45554481, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640542, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI85724806, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI116007136, Length=197, Percent_Identity=29.9492385786802, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221330162, Length=194, Percent_Identity=31.4432989690722, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221330166, Length=194, Percent_Identity=31.4432989690722, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221330164, Length=194, Percent_Identity=31.4432989690722, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_DEIGD (Q1IW06)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_605747.1
- ProteinModelPortal:   Q1IW06
- SMR:   Q1IW06
- STRING:   Q1IW06
- GeneID:   4059233
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_2284
- NMPDR:   fig|68909.1.peg.1392
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q1IW06
- ProtClustDB:   PRK00300
- BioCyc:   DGEO319795:DGEO_2284-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 27315; Mature: 27315

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSMMVARPDPQTTSSSSHRGLLIVMTGASGVGKGTLRERWLAGQDVFYSTSWTTREAR
CCCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEECCCCCCCCC
PGERDGVDYVFVTPEVFLEKVRQNGFLEHAQFVGNHYGTPTEPIEAALARGQDVVLEIEV
CCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEE
EGAMQVKERMGEEAVLVFIMPPSLTELRRRLTGRATETPERIEKRLQRARDEIMAAHAFR
CCHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
YVIVNDDLDRAVRELQAVQRAEHARQRPETEWTAEDRAAVQLAETVRSTVLTTEDLQRIV
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
NS
CC
>Mature Secondary Structure
MLPSMMVARPDPQTTSSSSHRGLLIVMTGASGVGKGTLRERWLAGQDVFYSTSWTTREAR
CCCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEECCCCCCCCC
PGERDGVDYVFVTPEVFLEKVRQNGFLEHAQFVGNHYGTPTEPIEAALARGQDVVLEIEV
CCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEE
EGAMQVKERMGEEAVLVFIMPPSLTELRRRLTGRATETPERIEKRLQRARDEIMAAHAFR
CCHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEE
YVIVNDDLDRAVRELQAVQRAEHARQRPETEWTAEDRAAVQLAETVRSTVLTTEDLQRIV
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
NS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA