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The map label for this gene is yccK [H]

Identifier: 94986270

GI number: 94986270

Start: 2286336

End: 2287310

Strand: Reverse

Name: yccK [H]

Synonym: Dgeo_2171

Alternate gene names: 94986270

Gene position: 2287310-2286336 (Counterclockwise)

Preceding gene: 94986271

Following gene: 94986263

Centisome position: 92.71

GC content: 67.18

Gene sequence:

>975_bases
ATGCAACACCGCAAGCTGCGCGAGCTTACCGTTTCCGCCCTGGGCCTGGGCTGCATGGGCATGAGCGAGTTCTACGGCGA
GGCCGACGAGCAGGAGTCCATCCGGGTGATCCACCGGGCGCTCGACCTGGGCGTGACCTTTTTGGACACCGCCGACATGT
ACGGTGTGGGCCGCAACGAGGAGCTGGTGGGGCGCGCCATTCGGGGTCGTCGGGACGAGGTGGTGCTGGCGACCAAGTTT
GGCAACGTGCGGGGGCCGAACGGGGAACGCCTGGGCATCAACGGCCGCCCCGAGTATGTGCGCCAGGCCTGTGACGCCAG
CCTGAAGCGGCTGGGAGTCGACCACATCGACCTGTACTACCAGCACCGCGTGGACCCCGACACGCCCATCGAGGAGACGG
TGGGGGCGATGGCTGAGCTGGTGCATGCGGGCAAGGTGCGCTTCCTGGGCCTCTCCGAGGCGTCGGCCGCGACCCTGCGC
CGCGCCAACGCCGTGCATCCCATCACCGCCCTTCAGAGCGAGTATTCCCTGTGGACCCGCGACCCGGAAGAGGAAGTGCT
GCCCACCTGCCGCGAGCTGGGCATCGGGTTCGTGGCGTATAGCCCCCTGGGACGCGGCTTTCTGAGCGGTCAGTTCCGGT
CGCCGGAGGATCTGCCCGCGGACGACTTCCGCCGCCACAATCCCCGCTTCCAGGGAGAGAACTTCCAGAAGAACTTGCGT
CTGGTTGAGGCCGTGCAGGACATGGCGCGCGAGAAGGGCTGCACGGCCTCGCAGCTCGCGCTGGCCTGGCTGCTCGCGCA
GGGGAACGACATCGTGCCGATTCCCGGCACCAAGCGGGTGAAGTACCTGGAAGACAATCTGGGCGCGCTGGACGTCCATC
TGAATGCGGACGATCTGGCGCAGCTCGAAGCCGTGTTCCCGATGGGTGCCGCCGCCGGAGAGCGTTACCCAGACATGAGC
AGTGTCAACCGCTAG

Upstream 100 bases:

>100_bases
ACTGGCGGCTTCTGCAGGGCCGATGCTTTAAGCCTTGCTCAAGCCGCCTCATGACGGAAGGTGCCCGCCAAGGCGCAGCC
TCAGCTTCAGGAGGTCAGAC

Downstream 100 bases:

>100_bases
GGTGCCTCTTCCCGTTGAGCTTCCTGTTCAGTGCCTGCTTAGTGCCCGCTTAGTGCCCGCTTGTCGCCTTGAGGCCAATG
ATCGCCACGATCATCATGCC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MQHRKLRELTVSALGLGCMGMSEFYGEADEQESIRVIHRALDLGVTFLDTADMYGVGRNEELVGRAIRGRRDEVVLATKF
GNVRGPNGERLGINGRPEYVRQACDASLKRLGVDHIDLYYQHRVDPDTPIEETVGAMAELVHAGKVRFLGLSEASAATLR
RANAVHPITALQSEYSLWTRDPEEEVLPTCRELGIGFVAYSPLGRGFLSGQFRSPEDLPADDFRRHNPRFQGENFQKNLR
LVEAVQDMAREKGCTASQLALAWLLAQGNDIVPIPGTKRVKYLEDNLGALDVHLNADDLAQLEAVFPMGAAAGERYPDMS
SVNR

Sequences:

>Translated_324_residues
MQHRKLRELTVSALGLGCMGMSEFYGEADEQESIRVIHRALDLGVTFLDTADMYGVGRNEELVGRAIRGRRDEVVLATKF
GNVRGPNGERLGINGRPEYVRQACDASLKRLGVDHIDLYYQHRVDPDTPIEETVGAMAELVHAGKVRFLGLSEASAATLR
RANAVHPITALQSEYSLWTRDPEEEVLPTCRELGIGFVAYSPLGRGFLSGQFRSPEDLPADDFRRHNPRFQGENFQKNLR
LVEAVQDMAREKGCTASQLALAWLLAQGNDIVPIPGTKRVKYLEDNLGALDVHLNADDLAQLEAVFPMGAAAGERYPDMS
SVNR
>Mature_324_residues
MQHRKLRELTVSALGLGCMGMSEFYGEADEQESIRVIHRALDLGVTFLDTADMYGVGRNEELVGRAIRGRRDEVVLATKF
GNVRGPNGERLGINGRPEYVRQACDASLKRLGVDHIDLYYQHRVDPDTPIEETVGAMAELVHAGKVRFLGLSEASAATLR
RANAVHPITALQSEYSLWTRDPEEEVLPTCRELGIGFVAYSPLGRGFLSGQFRSPEDLPADDFRRHNPRFQGENFQKNLR
LVEAVQDMAREKGCTASQLALAWLLAQGNDIVPIPGTKRVKYLEDNLGALDVHLNADDLAQLEAVFPMGAAAGERYPDMS
SVNR

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436966, Length=309, Percent_Identity=30.42071197411, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI27436964, Length=306, Percent_Identity=29.4117647058824, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI27436969, Length=321, Percent_Identity=27.1028037383178, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI4504825, Length=321, Percent_Identity=27.1028037383178, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI27436962, Length=309, Percent_Identity=30.0970873786408, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI27436971, Length=306, Percent_Identity=28.1045751633987, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223718702, Length=302, Percent_Identity=30.794701986755, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI41327764, Length=277, Percent_Identity=32.129963898917, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI41152114, Length=306, Percent_Identity=29.0849673202614, Blast_Score=88, Evalue=8e-18,
Organism=Escherichia coli, GI87081735, Length=326, Percent_Identity=36.1963190184049, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1788070, Length=306, Percent_Identity=34.640522875817, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789375, Length=306, Percent_Identity=32.3529411764706, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788081, Length=325, Percent_Identity=28, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789199, Length=350, Percent_Identity=31.1428571428571, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787674, Length=305, Percent_Identity=27.5409836065574, Blast_Score=106, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17564128, Length=332, Percent_Identity=23.4939759036145, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323998, Length=326, Percent_Identity=26.3803680981595, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319958, Length=305, Percent_Identity=25.5737704918033, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319951, Length=326, Percent_Identity=25.4601226993865, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6325384, Length=336, Percent_Identity=25.8928571428571, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325169, Length=328, Percent_Identity=25.9146341463415, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322615, Length=260, Percent_Identity=26.5384615384615, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45553081, Length=318, Percent_Identity=28.3018867924528, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281366140, Length=289, Percent_Identity=28.3737024221453, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24657054, Length=323, Percent_Identity=25.3869969040248, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20129731, Length=319, Percent_Identity=27.8996865203762, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646155, Length=307, Percent_Identity=25.7328990228013, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640980, Length=328, Percent_Identity=22.2560975609756, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45549126, Length=328, Percent_Identity=22.2560975609756, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646159, Length=222, Percent_Identity=27.9279279279279, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35889; Mature: 35889

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHRKLRELTVSALGLGCMGMSEFYGEADEQESIRVIHRALDLGVTFLDTADMYGVGRNE
CCCHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEECHHHHCCCCCH
ELVGRAIRGRRDEVVLATKFGNVRGPNGERLGINGRPEYVRQACDASLKRLGVDHIDLYY
HHHHHHHCCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCHHHHHHH
QHRVDPDTPIEETVGAMAELVHAGKVRFLGLSEASAATLRRANAVHPITALQSEYSLWTR
HCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
DPEEEVLPTCRELGIGFVAYSPLGRGFLSGQFRSPEDLPADDFRRHNPRFQGENFQKNLR
CCHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHH
LVEAVQDMAREKGCTASQLALAWLLAQGNDIVPIPGTKRVKYLEDNLGALDVHLNADDLA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHCCCCEEEEEECHHHHH
QLEAVFPMGAAAGERYPDMSSVNR
HHHHHCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MQHRKLRELTVSALGLGCMGMSEFYGEADEQESIRVIHRALDLGVTFLDTADMYGVGRNE
CCCHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEECHHHHCCCCCH
ELVGRAIRGRRDEVVLATKFGNVRGPNGERLGINGRPEYVRQACDASLKRLGVDHIDLYY
HHHHHHHCCCCCCEEEEEECCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCHHHHHHH
QHRVDPDTPIEETVGAMAELVHAGKVRFLGLSEASAATLRRANAVHPITALQSEYSLWTR
HCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
DPEEEVLPTCRELGIGFVAYSPLGRGFLSGQFRSPEDLPADDFRRHNPRFQGENFQKNLR
CCHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHH
LVEAVQDMAREKGCTASQLALAWLLAQGNDIVPIPGTKRVKYLEDNLGALDVHLNADDLA
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHCCCCEEEEEECHHHHH
QLEAVFPMGAAAGERYPDMSSVNR
HHHHHCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9106203 [H]