Click here to switch to the map view.

The map label for this gene is echA12 [H]

Identifier: 94986261

GI number: 94986261

Start: 2278701

End: 2279522

Strand: Reverse

Name: echA12 [H]

Synonym: Dgeo_2162

Alternate gene names: 94986261

Gene position: 2279522-2278701 (Counterclockwise)

Preceding gene: 94986262

Following gene: 94986260

Centisome position: 92.39

GC content: 68.0

Gene sequence:

>822_bases
ATGCACCCCGAAGAGCTCACCGCGCCGGGCGCCTACCCTGGCCTGCACCTGTCCCTGACCGACGACGGCATCCTCGAGAT
TGTCATCCGCAGCGGGAAGACGTTGGGCAGCGTGAATGCCGAGGCGCACCGAGCGCTCACGTCCATCTGGCGCGACATCG
ACACCGCCAAAGGCGTCCGCTGCGTGCTGATTCGTGGTGAGGGGCGGGCGTTCTCGTCGGGCGGCGACTTCAGCCTGATT
GAAGAGATGGCAGGAGACTTCACGGCGCTGACCCGCGTGTGGAAGGAAGCCCGCGACCTCGTCTACAACGTCATCAACTG
CGGTAAGCCCATCGTGAGCGCGATTCATGGCCCCTGCGTCGGCGCGGGCCTGGCTGTCGCGCTGCTGGCCGACGTGAGTG
TGGCGGCGAGGAACGCCCGGATTCTGGATGGACATGTTCGGCTTGGTGTGGCGGCGGGCGACCACGCGGCGATCATCTGG
CCGCTGCTGTGTGGCCTCAACAAGGCCAAGTACCACCTCCTGACCGGCGAACCCGTCTCCGGCGAGGAGGCCGAGCGCAT
CGGCCTGGTCAGCCTCTGCGTGCCCGATGACGAGCTGCTCCCGCGTGCCTGGCAGGTGGCCCGCCGCCTGGCGAGTGGCA
GTCCTACGGCCGTCCGCTGGACCAAATACGCCCTGAACAACTGGCTGCGGGCGATGGGGCCGACCTTCGATGCCAGCCTC
GCCCTGGAATTCCTGGGCTTTACGGGGCCGGACGTGCGCGAGGGCCTCGCCAGCCTGCGCGAGAAGCGCGAGCCGCGGTT
TCAGGAGGACGCGCCGCTTTGA

Upstream 100 bases:

>100_bases
CAGGCCGCAGGTGACAAGCCGCACAGGCAGGATAGGAGCTGACCGCGCCGGAGGAGGATGCAAAGGCGGCGCCTCCTTTT
GGGGGTGTTAGCCTGCCTCC

Downstream 100 bases:

>100_bases
AGGGGCACTTTGAAGGGGCACTTTGAAGGGGCAGGACTGAGGAGGAAAGCTGTGACGCTTCCCCCCTGTCCCCCCCACGG
GAACGCCCCCTCCCCACCTT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MHPEELTAPGAYPGLHLSLTDDGILEIVIRSGKTLGSVNAEAHRALTSIWRDIDTAKGVRCVLIRGEGRAFSSGGDFSLI
EEMAGDFTALTRVWKEARDLVYNVINCGKPIVSAIHGPCVGAGLAVALLADVSVAARNARILDGHVRLGVAAGDHAAIIW
PLLCGLNKAKYHLLTGEPVSGEEAERIGLVSLCVPDDELLPRAWQVARRLASGSPTAVRWTKYALNNWLRAMGPTFDASL
ALEFLGFTGPDVREGLASLREKREPRFQEDAPL

Sequences:

>Translated_273_residues
MHPEELTAPGAYPGLHLSLTDDGILEIVIRSGKTLGSVNAEAHRALTSIWRDIDTAKGVRCVLIRGEGRAFSSGGDFSLI
EEMAGDFTALTRVWKEARDLVYNVINCGKPIVSAIHGPCVGAGLAVALLADVSVAARNARILDGHVRLGVAAGDHAAIIW
PLLCGLNKAKYHLLTGEPVSGEEAERIGLVSLCVPDDELLPRAWQVARRLASGSPTAVRWTKYALNNWLRAMGPTFDASL
ALEFLGFTGPDVREGLASLREKREPRFQEDAPL
>Mature_273_residues
MHPEELTAPGAYPGLHLSLTDDGILEIVIRSGKTLGSVNAEAHRALTSIWRDIDTAKGVRCVLIRGEGRAFSSGGDFSLI
EEMAGDFTALTRVWKEARDLVYNVINCGKPIVSAIHGPCVGAGLAVALLADVSVAARNARILDGHVRLGVAAGDHAAIIW
PLLCGLNKAKYHLLTGEPVSGEEAERIGLVSLCVPDDELLPRAWQVARRLASGSPTAVRWTKYALNNWLRAMGPTFDASL
ALEFLGFTGPDVREGLASLREKREPRFQEDAPL

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=27.6, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI194097323, Length=232, Percent_Identity=25, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI70995211, Length=229, Percent_Identity=27.5109170305677, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI20127408, Length=191, Percent_Identity=25.6544502617801, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787659, Length=225, Percent_Identity=33.7777777777778, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=28.4046692607004, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI221142681, Length=216, Percent_Identity=26.8518518518519, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788682, Length=211, Percent_Identity=26.5402843601896, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=243, Percent_Identity=28.3950617283951, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI25145438, Length=216, Percent_Identity=26.3888888888889, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=265, Percent_Identity=26.0377358490566, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=217, Percent_Identity=24.4239631336406, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=182, Percent_Identity=29.1208791208791, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24653477, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922422, Length=251, Percent_Identity=24.3027888446215, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=25.1366120218579, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920382, Length=228, Percent_Identity=25, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24653139, Length=232, Percent_Identity=26.7241379310345, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357171, Length=209, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29349; Mature: 29349

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPEELTAPGAYPGLHLSLTDDGILEIVIRSGKTLGSVNAEAHRALTSIWRDIDTAKGVR
CCCCCCCCCCCCCCEEEEECCCCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
CVLIRGEGRAFSSGGDFSLIEEMAGDFTALTRVWKEARDLVYNVINCGKPIVSAIHGPCV
EEEEECCCCEECCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHH
GAGLAVALLADVSVAARNARILDGHVRLGVAAGDHAAIIWPLLCGLNKAKYHLLTGEPVS
HHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCC
GEEAERIGLVSLCVPDDELLPRAWQVARRLASGSPTAVRWTKYALNNWLRAMGPTFDASL
CCCHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCHHH
ALEFLGFTGPDVREGLASLREKREPRFQEDAPL
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MHPEELTAPGAYPGLHLSLTDDGILEIVIRSGKTLGSVNAEAHRALTSIWRDIDTAKGVR
CCCCCCCCCCCCCCEEEEECCCCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEE
CVLIRGEGRAFSSGGDFSLIEEMAGDFTALTRVWKEARDLVYNVINCGKPIVSAIHGPCV
EEEEECCCCEECCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHH
GAGLAVALLADVSVAARNARILDGHVRLGVAAGDHAAIIWPLLCGLNKAKYHLLTGEPVS
HHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCC
GEEAERIGLVSLCVPDDELLPRAWQVARRLASGSPTAVRWTKYALNNWLRAMGPTFDASL
CCCHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCHHH
ALEFLGFTGPDVREGLASLREKREPRFQEDAPL
HHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]