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The map label for this gene is pth

Identifier: 94986155

GI number: 94986155

Start: 2162884

End: 2163528

Strand: Reverse

Name: pth

Synonym: Dgeo_2056

Alternate gene names: 94986155

Gene position: 2163528-2162884 (Counterclockwise)

Preceding gene: 94986157

Following gene: 94986154

Centisome position: 87.69

GC content: 67.6

Gene sequence:

>645_bases
ATGAAACTGGTTGTGGGTCTCGGCAATCCGGGCAGCCAGTATGCCCAGACCCGTCATAACGTCGGCTGGTTGGTCGTGGA
TGAGGTGGCCCGGCGCTGGGGAGCGGTCTGGCACCCAGACAAGGACGCGGAAGTGGCCGAGCTGCGGATGGGGGCGGCGC
CGGGCGAGAAGGTGCTGCTGGTCAAGCCGCAGACCTTCATGAACTCGTCGGGGAGGGCCGTGGGACCACTGTTTGCCTTC
TACAAGCTGGAGCCTGCCGCCTTGCTGGTGGTGCAAGATGACCTTGACAGCCCATTTGGCCTGCTGAAGTTCCGCCTGGG
AGGGCGGCACGGCGGACAGAACGGGGTGCGTGACATCATTCGCGTGCTGGGTACCCAGGATTTTGCGCGTCTGAAGATCG
GCATCTCGCGGCCTCCGGCAGGTTGGAACCCCGCCGACTGGGTGCTGAGCCGCTGGCGCGCGGAGGAGGCGGAGACGCTC
GCGGAACTCGTCCGGCTGGGGGCCGACGCGGTGGAGGTTTGGGTGAGCCACGGGCTGGCCGAGGGGCAGGCGCGCTTTAA
CGGCACGGATCTGCGCCCGAAGCCGGACCCTGCGCCTCAGCCCCGGGTGGAGGCGGCAGATGCTGGCCCGCATCACCCCA
CCTAA

Upstream 100 bases:

>100_bases
GCTTCCGGACCGGGTATGCCCGCGCCAAGGGTGACCCCCGCGTGCGCGAGACCGAAGCCCGCTGGCGCGCGACGCTGGAC
AGCCTGGAGGCCTGAAGCGC

Downstream 100 bases:

>100_bases
CGTAGAGCAACGGGCCTATGTGTTGCCCGAAAAGCCCGGTGTTGAGATCTAAAAGATGAGCCGGTAGACCTGCTGCTGTC
TACCTCAGCTGAAATTTGGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKLVVGLGNPGSQYAQTRHNVGWLVVDEVARRWGAVWHPDKDAEVAELRMGAAPGEKVLLVKPQTFMNSSGRAVGPLFAF
YKLEPAALLVVQDDLDSPFGLLKFRLGGRHGGQNGVRDIIRVLGTQDFARLKIGISRPPAGWNPADWVLSRWRAEEAETL
AELVRLGADAVEVWVSHGLAEGQARFNGTDLRPKPDPAPQPRVEAADAGPHHPT

Sequences:

>Translated_214_residues
MKLVVGLGNPGSQYAQTRHNVGWLVVDEVARRWGAVWHPDKDAEVAELRMGAAPGEKVLLVKPQTFMNSSGRAVGPLFAF
YKLEPAALLVVQDDLDSPFGLLKFRLGGRHGGQNGVRDIIRVLGTQDFARLKIGISRPPAGWNPADWVLSRWRAEEAETL
AELVRLGADAVEVWVSHGLAEGQARFNGTDLRPKPDPAPQPRVEAADAGPHHPT
>Mature_214_residues
MKLVVGLGNPGSQYAQTRHNVGWLVVDEVARRWGAVWHPDKDAEVAELRMGAAPGEKVLLVKPQTFMNSSGRAVGPLFAF
YKLEPAALLVVQDDLDSPFGLLKFRLGGRHGGQNGVRDIIRVLGTQDFARLKIGISRPPAGWNPADWVLSRWRAEEAETL
AELVRLGADAVEVWVSHGLAEGQARFNGTDLRPKPDPAPQPRVEAADAGPHHPT

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=171, Percent_Identity=34.5029239766082, Blast_Score=94, Evalue=7e-20,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=39.2670157068063, Blast_Score=112, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321983, Length=166, Percent_Identity=30.1204819277108, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_DEIGD (Q1IWN4)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_605519.1
- ProteinModelPortal:   Q1IWN4
- SMR:   Q1IWN4
- STRING:   Q1IWN4
- GeneID:   4058402
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_2056
- NMPDR:   fig|68909.1.peg.2241
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   Q1IWN4
- ProtClustDB:   PRK05426
- BioCyc:   DGEO319795:DGEO_2056-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 23311; Mature: 23311

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVGLGNPGSQYAQTRHNVGWLVVDEVARRWGAVWHPDKDAEVAELRMGAAPGEKVLL
CEEEEECCCCCHHHHHHHHCCCEEEHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEE
VKPQTFMNSSGRAVGPLFAFYKLEPAALLVVQDDLDSPFGLLKFRLGGRHGGQNGVRDII
ECCHHHHCCCCCCHHHHHHHEEECCEEEEEEECCCCCCHHEEEEEECCCCCCCHHHHHHH
RVLGTQDFARLKIGISRPPAGWNPADWVLSRWRAEEAETLAELVRLGADAVEVWVSHGLA
HHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCHHHHHHHHHHCCC
EGQARFNGTDLRPKPDPAPQPRVEAADAGPHHPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLVVGLGNPGSQYAQTRHNVGWLVVDEVARRWGAVWHPDKDAEVAELRMGAAPGEKVLL
CEEEEECCCCCHHHHHHHHCCCEEEHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEE
VKPQTFMNSSGRAVGPLFAFYKLEPAALLVVQDDLDSPFGLLKFRLGGRHGGQNGVRDII
ECCHHHHCCCCCCHHHHHHHEEECCEEEEEEECCCCCCHHEEEEEECCCCCCCHHHHHHH
RVLGTQDFARLKIGISRPPAGWNPADWVLSRWRAEEAETLAELVRLGADAVEVWVSHGLA
HHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCHHHHHHHHHHCCC
EGQARFNGTDLRPKPDPAPQPRVEAADAGPHHPT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA